Effects of gut microbiota and probiotics on Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disease with high morbidity, disability, and fatality rate, significantly increasing the global burden of public health. The failure in drug discovery over the past decades has stressed the urgency and importance of seeking new perspectives...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2021-12-01
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| Series: | Translational Neuroscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/tnsci-2020-0203 |
| _version_ | 1811280603597766656 |
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| author | Guo Libing Xu Jiaxin Du Yunhua Wu Weibo Nie Wenjing Zhang Dongliang Luo Yuling Lu Huixian Lei Ming Xiao Songhua Liu Jun |
| author_facet | Guo Libing Xu Jiaxin Du Yunhua Wu Weibo Nie Wenjing Zhang Dongliang Luo Yuling Lu Huixian Lei Ming Xiao Songhua Liu Jun |
| author_sort | Guo Libing |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a progressive neurodegenerative disease with high morbidity, disability, and fatality rate, significantly increasing the global burden of public health. The failure in drug discovery over the past decades has stressed the urgency and importance of seeking new perspectives. Recently, gut microbiome (GM), with the ability to communicate with the brain bidirectionally through the microbiome–gut–brain axis, has attracted much attention in AD-related studies, owing to their strong associations with amyloids, systematic and focal inflammation, impairment of vascular homeostasis and gut barrier, mitochondrial dysfunction, etc., making the regulation of GM, specifically supplementation of probiotics a promising candidate for AD treatment. This article aims to review the leading-edge knowledge concerning potential roles of GM in AD pathogenesis and of probiotics in its treatment and prevention. |
| first_indexed | 2024-04-13T01:17:48Z |
| format | Article |
| id | doaj.art-79b02bccc8734c09ad2ce4a6fa2cd5a4 |
| institution | Directory Open Access Journal |
| issn | 2081-6936 |
| language | English |
| last_indexed | 2024-04-13T01:17:48Z |
| publishDate | 2021-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Translational Neuroscience |
| spelling | doaj.art-79b02bccc8734c09ad2ce4a6fa2cd5a42022-12-22T03:08:52ZengDe GruyterTranslational Neuroscience2081-69362021-12-0112157358010.1515/tnsci-2020-0203Effects of gut microbiota and probiotics on Alzheimer’s diseaseGuo Libing0Xu Jiaxin1Du Yunhua2Wu Weibo3Nie Wenjing4Zhang Dongliang5Luo Yuling6Lu Huixian7Lei Ming8Xiao Songhua9Liu Jun10Department of Neurology, Foshan Third People’s Hospital, No. 102 Jinlan South Road, Foshan, Guangdong, ChinaDepartment of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang West Road, Guangzhou, Guangdong, ChinaDepartment of Neurology, Foshan Third People’s Hospital, No. 102 Jinlan South Road, Foshan, Guangdong, ChinaDepartment of Neurology, Foshan Third People’s Hospital, No. 102 Jinlan South Road, Foshan, Guangdong, ChinaDepartment of Neurology, Foshan Third People’s Hospital, No. 102 Jinlan South Road, Foshan, Guangdong, ChinaDepartment of Neurology, Foshan Third People’s Hospital, No. 102 Jinlan South Road, Foshan, Guangdong, ChinaDepartment of Neurology, Foshan Third People’s Hospital, No. 102 Jinlan South Road, Foshan, Guangdong, ChinaDepartment of Neurology, Foshan Third People’s Hospital, No. 102 Jinlan South Road, Foshan, Guangdong, ChinaDepartment of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang West Road, Guangzhou, Guangdong, ChinaDepartment of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang West Road, Guangzhou, Guangdong, ChinaDepartment of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, No. 107 Yanjiang West Road, Guangzhou, Guangdong, ChinaAlzheimer’s disease (AD) is a progressive neurodegenerative disease with high morbidity, disability, and fatality rate, significantly increasing the global burden of public health. The failure in drug discovery over the past decades has stressed the urgency and importance of seeking new perspectives. Recently, gut microbiome (GM), with the ability to communicate with the brain bidirectionally through the microbiome–gut–brain axis, has attracted much attention in AD-related studies, owing to their strong associations with amyloids, systematic and focal inflammation, impairment of vascular homeostasis and gut barrier, mitochondrial dysfunction, etc., making the regulation of GM, specifically supplementation of probiotics a promising candidate for AD treatment. This article aims to review the leading-edge knowledge concerning potential roles of GM in AD pathogenesis and of probiotics in its treatment and prevention.https://doi.org/10.1515/tnsci-2020-0203alzheimer’s diseasegut microbiotaprobiotics |
| spellingShingle | Guo Libing Xu Jiaxin Du Yunhua Wu Weibo Nie Wenjing Zhang Dongliang Luo Yuling Lu Huixian Lei Ming Xiao Songhua Liu Jun Effects of gut microbiota and probiotics on Alzheimer’s disease Translational Neuroscience alzheimer’s disease gut microbiota probiotics |
| title | Effects of gut microbiota and probiotics on Alzheimer’s disease |
| title_full | Effects of gut microbiota and probiotics on Alzheimer’s disease |
| title_fullStr | Effects of gut microbiota and probiotics on Alzheimer’s disease |
| title_full_unstemmed | Effects of gut microbiota and probiotics on Alzheimer’s disease |
| title_short | Effects of gut microbiota and probiotics on Alzheimer’s disease |
| title_sort | effects of gut microbiota and probiotics on alzheimer s disease |
| topic | alzheimer’s disease gut microbiota probiotics |
| url | https://doi.org/10.1515/tnsci-2020-0203 |
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