<i>MYCN</i> Amplification, along with Wild-Type RB1 Expression, Enhances CDK4/6 Inhibitors’ Efficacy in Neuroblastoma Cells

<i>MYCN</i> Amplification, along with Wild-Type RB1 Expression, Enhances CDK4/6 Inhibitors’ Efficacy in Neuroblastoma Cells

Neuroblastoma (NB) is one of the primary causes of death for pediatric malignancies. Given the high heterogeneity in NB’s mutation landscape, optimizing individualized therapies is still challenging. In the context of genomic alterations, <i>MYCN</i> amplification is the most correlated...

Full description

Bibliographic Details
Main Authors: Piergiuseppe De Rosa, Federica Severi, Suleman Khan Zadran, Marco Russo, Sara Aloisi, Alberto Rigamonti, Giovanni Capranico, Giorgio Milazzo, Giovanni Perini
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
Neuroblastoma
MYCN
RB
E2F
palbociclib
ribociclib
Online Access:https://www.mdpi.com/1422-0067/24/6/5408

Internet

https://www.mdpi.com/1422-0067/24/6/5408

Similar Items