The development of common data elements for a multi-institute prostate cancer tissue bank: The Cooperative Prostate Cancer Tissue Resource (CPCTR) experience
<p>Abstract</p> <p>Background</p> <p>The Cooperative Prostate Cancer Tissue Resource (CPCTR) is a consortium of four geographically dispersed institutions that are funded by the U.S. National Cancer Institute (NCI) to provide clinically annotated prostate cancer tissue...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2005-08-01
|
| Series: | BMC Cancer |
| Online Access: | http://www.biomedcentral.com/1471-2407/5/108 |
| _version_ | 1818471534626340864 |
|---|---|
| author | Melamed Jonathan Gilbertson John Dhir Rajiv Datta Milton W Bosland Maarten Berman Jules J Kajdacsy-Balla André Patel Ashokkumar A Orenstein Jan Tai Kuei-Fang Becich Michael J |
| author_facet | Melamed Jonathan Gilbertson John Dhir Rajiv Datta Milton W Bosland Maarten Berman Jules J Kajdacsy-Balla André Patel Ashokkumar A Orenstein Jan Tai Kuei-Fang Becich Michael J |
| author_sort | Melamed Jonathan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The Cooperative Prostate Cancer Tissue Resource (CPCTR) is a consortium of four geographically dispersed institutions that are funded by the U.S. National Cancer Institute (NCI) to provide clinically annotated prostate cancer tissue samples to researchers. To facilitate this effort, it was critical to arrive at agreed upon common data elements (CDEs) that could be used to collect demographic, pathologic, treatment and clinical outcome data.</p> <p>Methods</p> <p>The CPCTR investigators convened a CDE curation subcommittee to develop and implement CDEs for the annotation of collected prostate tissues. The draft CDEs were refined and progressively annotated to make them ISO 11179 compliant. The CDEs were implemented in the CPCTR database and tested using software query tools developed by the investigators.</p> <p>Results</p> <p>By collaborative consensus the CPCTR CDE subcommittee developed 145 data elements to annotate the tissue samples collected. These included for each case: 1) demographic data, 2) clinical history, 3) pathology specimen level elements to describe the staging, grading and other characteristics of individual surgical pathology cases, 4) tissue block level annotation critical to managing a virtual inventory of cases and facilitating case selection, and 5) clinical outcome data including treatment, recurrence and vital status. These elements have been used successfully to respond to over 60 requests by end-users for tissue, including paraffin blocks from cases with 5 to 10 years of follow up, tissue microarrays (TMAs), as well as frozen tissue collected prospectively for genomic profiling and genetic studies. The CPCTR CDEs have been fully implemented in two major tissue banks and have been shared with dozens of other tissue banking efforts.</p> <p>Conclusion</p> <p>The freely available CDEs developed by the CPCTR are robust, based on "best practices" for tissue resources, and are ISO 11179 compliant. The process for CDE development described in this manuscript provides a framework model for other organ sites and has been used as a model for breast and melanoma tissue banking efforts.</p> |
| first_indexed | 2024-04-14T03:52:30Z |
| format | Article |
| id | doaj.art-79b1b0df355f48e79bcdb7e0c4d047eb |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-14T03:52:30Z |
| publishDate | 2005-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-79b1b0df355f48e79bcdb7e0c4d047eb2022-12-22T02:13:57ZengBMCBMC Cancer1471-24072005-08-015110810.1186/1471-2407-5-108The development of common data elements for a multi-institute prostate cancer tissue bank: The Cooperative Prostate Cancer Tissue Resource (CPCTR) experienceMelamed JonathanGilbertson JohnDhir RajivDatta Milton WBosland MaartenBerman Jules JKajdacsy-Balla AndréPatel Ashokkumar AOrenstein JanTai Kuei-FangBecich Michael J<p>Abstract</p> <p>Background</p> <p>The Cooperative Prostate Cancer Tissue Resource (CPCTR) is a consortium of four geographically dispersed institutions that are funded by the U.S. National Cancer Institute (NCI) to provide clinically annotated prostate cancer tissue samples to researchers. To facilitate this effort, it was critical to arrive at agreed upon common data elements (CDEs) that could be used to collect demographic, pathologic, treatment and clinical outcome data.</p> <p>Methods</p> <p>The CPCTR investigators convened a CDE curation subcommittee to develop and implement CDEs for the annotation of collected prostate tissues. The draft CDEs were refined and progressively annotated to make them ISO 11179 compliant. The CDEs were implemented in the CPCTR database and tested using software query tools developed by the investigators.</p> <p>Results</p> <p>By collaborative consensus the CPCTR CDE subcommittee developed 145 data elements to annotate the tissue samples collected. These included for each case: 1) demographic data, 2) clinical history, 3) pathology specimen level elements to describe the staging, grading and other characteristics of individual surgical pathology cases, 4) tissue block level annotation critical to managing a virtual inventory of cases and facilitating case selection, and 5) clinical outcome data including treatment, recurrence and vital status. These elements have been used successfully to respond to over 60 requests by end-users for tissue, including paraffin blocks from cases with 5 to 10 years of follow up, tissue microarrays (TMAs), as well as frozen tissue collected prospectively for genomic profiling and genetic studies. The CPCTR CDEs have been fully implemented in two major tissue banks and have been shared with dozens of other tissue banking efforts.</p> <p>Conclusion</p> <p>The freely available CDEs developed by the CPCTR are robust, based on "best practices" for tissue resources, and are ISO 11179 compliant. The process for CDE development described in this manuscript provides a framework model for other organ sites and has been used as a model for breast and melanoma tissue banking efforts.</p>http://www.biomedcentral.com/1471-2407/5/108 |
| spellingShingle | Melamed Jonathan Gilbertson John Dhir Rajiv Datta Milton W Bosland Maarten Berman Jules J Kajdacsy-Balla André Patel Ashokkumar A Orenstein Jan Tai Kuei-Fang Becich Michael J The development of common data elements for a multi-institute prostate cancer tissue bank: The Cooperative Prostate Cancer Tissue Resource (CPCTR) experience BMC Cancer |
| title | The development of common data elements for a multi-institute prostate cancer tissue bank: The Cooperative Prostate Cancer Tissue Resource (CPCTR) experience |
| title_full | The development of common data elements for a multi-institute prostate cancer tissue bank: The Cooperative Prostate Cancer Tissue Resource (CPCTR) experience |
| title_fullStr | The development of common data elements for a multi-institute prostate cancer tissue bank: The Cooperative Prostate Cancer Tissue Resource (CPCTR) experience |
| title_full_unstemmed | The development of common data elements for a multi-institute prostate cancer tissue bank: The Cooperative Prostate Cancer Tissue Resource (CPCTR) experience |
| title_short | The development of common data elements for a multi-institute prostate cancer tissue bank: The Cooperative Prostate Cancer Tissue Resource (CPCTR) experience |
| title_sort | development of common data elements for a multi institute prostate cancer tissue bank the cooperative prostate cancer tissue resource cpctr experience |
| url | http://www.biomedcentral.com/1471-2407/5/108 |
| work_keys_str_mv | AT melamedjonathan thedevelopmentofcommondataelementsforamultiinstituteprostatecancertissuebankthecooperativeprostatecancertissueresourcecpctrexperience AT gilbertsonjohn thedevelopmentofcommondataelementsforamultiinstituteprostatecancertissuebankthecooperativeprostatecancertissueresourcecpctrexperience AT dhirrajiv thedevelopmentofcommondataelementsforamultiinstituteprostatecancertissuebankthecooperativeprostatecancertissueresourcecpctrexperience AT dattamiltonw thedevelopmentofcommondataelementsforamultiinstituteprostatecancertissuebankthecooperativeprostatecancertissueresourcecpctrexperience AT boslandmaarten thedevelopmentofcommondataelementsforamultiinstituteprostatecancertissuebankthecooperativeprostatecancertissueresourcecpctrexperience AT bermanjulesj thedevelopmentofcommondataelementsforamultiinstituteprostatecancertissuebankthecooperativeprostatecancertissueresourcecpctrexperience AT kajdacsyballaandre thedevelopmentofcommondataelementsforamultiinstituteprostatecancertissuebankthecooperativeprostatecancertissueresourcecpctrexperience AT patelashokkumara thedevelopmentofcommondataelementsforamultiinstituteprostatecancertissuebankthecooperativeprostatecancertissueresourcecpctrexperience AT orensteinjan thedevelopmentofcommondataelementsforamultiinstituteprostatecancertissuebankthecooperativeprostatecancertissueresourcecpctrexperience AT taikueifang thedevelopmentofcommondataelementsforamultiinstituteprostatecancertissuebankthecooperativeprostatecancertissueresourcecpctrexperience AT becichmichaelj thedevelopmentofcommondataelementsforamultiinstituteprostatecancertissuebankthecooperativeprostatecancertissueresourcecpctrexperience AT melamedjonathan developmentofcommondataelementsforamultiinstituteprostatecancertissuebankthecooperativeprostatecancertissueresourcecpctrexperience AT gilbertsonjohn developmentofcommondataelementsforamultiinstituteprostatecancertissuebankthecooperativeprostatecancertissueresourcecpctrexperience AT dhirrajiv developmentofcommondataelementsforamultiinstituteprostatecancertissuebankthecooperativeprostatecancertissueresourcecpctrexperience AT dattamiltonw developmentofcommondataelementsforamultiinstituteprostatecancertissuebankthecooperativeprostatecancertissueresourcecpctrexperience AT boslandmaarten developmentofcommondataelementsforamultiinstituteprostatecancertissuebankthecooperativeprostatecancertissueresourcecpctrexperience AT bermanjulesj developmentofcommondataelementsforamultiinstituteprostatecancertissuebankthecooperativeprostatecancertissueresourcecpctrexperience AT kajdacsyballaandre developmentofcommondataelementsforamultiinstituteprostatecancertissuebankthecooperativeprostatecancertissueresourcecpctrexperience AT patelashokkumara developmentofcommondataelementsforamultiinstituteprostatecancertissuebankthecooperativeprostatecancertissueresourcecpctrexperience AT orensteinjan developmentofcommondataelementsforamultiinstituteprostatecancertissuebankthecooperativeprostatecancertissueresourcecpctrexperience AT taikueifang developmentofcommondataelementsforamultiinstituteprostatecancertissuebankthecooperativeprostatecancertissueresourcecpctrexperience AT becichmichaelj developmentofcommondataelementsforamultiinstituteprostatecancertissuebankthecooperativeprostatecancertissueresourcecpctrexperience |