Dysregulated noradrenergic response is associated with symptom severity in individuals with schizophrenia
IntroductionThe locus coeruleus-noradrenaline (LC-NA) system is involved in a wide range of cognitive functions and may be altered in schizophrenia. A non-invasive method to indirectly measure LC activity is task-evoked pupillary response. Individuals with schizophrenia present reduced pupil dilatio...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1190329/full |
| _version_ | 1797635115854069760 |
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| author | Ana Pelegrino Ana Pelegrino Anna Luiza Guimaraes Anna Luiza Guimaraes Walter Sena Walter Sena Nwabunwanne Emele Nwabunwanne Emele Linda Scoriels Linda Scoriels Rogerio Panizzutti Rogerio Panizzutti |
| author_facet | Ana Pelegrino Ana Pelegrino Anna Luiza Guimaraes Anna Luiza Guimaraes Walter Sena Walter Sena Nwabunwanne Emele Nwabunwanne Emele Linda Scoriels Linda Scoriels Rogerio Panizzutti Rogerio Panizzutti |
| author_sort | Ana Pelegrino |
| collection | DOAJ |
| description | IntroductionThe locus coeruleus-noradrenaline (LC-NA) system is involved in a wide range of cognitive functions and may be altered in schizophrenia. A non-invasive method to indirectly measure LC activity is task-evoked pupillary response. Individuals with schizophrenia present reduced pupil dilation compared to healthy subjects, particularly when task demand increases. However, the extent to which alteration in LC activity contributes to schizophrenia symptomatology remains largely unexplored. We aimed to investigate the association between symptomatology, cognition, and noradrenergic response in individuals with schizophrenia.MethodsWe assessed task-evoked pupil dilation during a pro- and antisaccade task in 23 individuals with schizophrenia and 28 healthy subjects.ResultsBoth groups showed similar preparatory pupil dilation during prosaccade trials, but individuals with schizophrenia showed significantly lower pupil dilation compared to healthy subjects in antisaccade trials. Importantly, reduced preparatory pupil dilation for antisaccade trials was associated with worse general symptomatology in individuals with schizophrenia.DiscussionOur findings suggest that changes in LC-NA activity – measured by task-evoked pupil dilation – when task demand increases is associated with schizophrenia symptoms. Interventions targeting the modulation of noradrenergic responses may be suitable candidates to reduce schizophrenia symptomatology. |
| first_indexed | 2024-03-11T12:17:41Z |
| format | Article |
| id | doaj.art-79b2aab05cb042bbb341ad1249e4392f |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-03-11T12:17:41Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-79b2aab05cb042bbb341ad1249e4392f2023-11-07T07:32:05ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-11-011410.3389/fpsyt.2023.11903291190329Dysregulated noradrenergic response is associated with symptom severity in individuals with schizophreniaAna Pelegrino0Ana Pelegrino1Anna Luiza Guimaraes2Anna Luiza Guimaraes3Walter Sena4Walter Sena5Nwabunwanne Emele6Nwabunwanne Emele7Linda Scoriels8Linda Scoriels9Rogerio Panizzutti10Rogerio Panizzutti11Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilInstituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilInstituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilInstituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilInstituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilUniversité Paris Cité, Institut de Psychiatrie et Neurosciences de Paris, Inserm, Paris, FranceInstituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilIntroductionThe locus coeruleus-noradrenaline (LC-NA) system is involved in a wide range of cognitive functions and may be altered in schizophrenia. A non-invasive method to indirectly measure LC activity is task-evoked pupillary response. Individuals with schizophrenia present reduced pupil dilation compared to healthy subjects, particularly when task demand increases. However, the extent to which alteration in LC activity contributes to schizophrenia symptomatology remains largely unexplored. We aimed to investigate the association between symptomatology, cognition, and noradrenergic response in individuals with schizophrenia.MethodsWe assessed task-evoked pupil dilation during a pro- and antisaccade task in 23 individuals with schizophrenia and 28 healthy subjects.ResultsBoth groups showed similar preparatory pupil dilation during prosaccade trials, but individuals with schizophrenia showed significantly lower pupil dilation compared to healthy subjects in antisaccade trials. Importantly, reduced preparatory pupil dilation for antisaccade trials was associated with worse general symptomatology in individuals with schizophrenia.DiscussionOur findings suggest that changes in LC-NA activity – measured by task-evoked pupil dilation – when task demand increases is associated with schizophrenia symptoms. Interventions targeting the modulation of noradrenergic responses may be suitable candidates to reduce schizophrenia symptomatology.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1190329/fullschizophreniacognitionsymptom severitylocus coeruleusnoradrenergic responsepupil dilation |
| spellingShingle | Ana Pelegrino Ana Pelegrino Anna Luiza Guimaraes Anna Luiza Guimaraes Walter Sena Walter Sena Nwabunwanne Emele Nwabunwanne Emele Linda Scoriels Linda Scoriels Rogerio Panizzutti Rogerio Panizzutti Dysregulated noradrenergic response is associated with symptom severity in individuals with schizophrenia Frontiers in Psychiatry schizophrenia cognition symptom severity locus coeruleus noradrenergic response pupil dilation |
| title | Dysregulated noradrenergic response is associated with symptom severity in individuals with schizophrenia |
| title_full | Dysregulated noradrenergic response is associated with symptom severity in individuals with schizophrenia |
| title_fullStr | Dysregulated noradrenergic response is associated with symptom severity in individuals with schizophrenia |
| title_full_unstemmed | Dysregulated noradrenergic response is associated with symptom severity in individuals with schizophrenia |
| title_short | Dysregulated noradrenergic response is associated with symptom severity in individuals with schizophrenia |
| title_sort | dysregulated noradrenergic response is associated with symptom severity in individuals with schizophrenia |
| topic | schizophrenia cognition symptom severity locus coeruleus noradrenergic response pupil dilation |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1190329/full |
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