Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans
How phosphorylation mediated by Insulin/IGF-1 Signaling kinases regulates lifespan remains unclear. Here the authors perform a large-scale quantitative phosphoproteomic analysis of wildtype and IIS mutant C. elegans strains to reveal detailed functional insights into longevity.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24816-z |
| _version_ | 1819200351828443136 |
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| author | Wen-Jun Li Chen-Wei Wang Li Tao Yong-Hong Yan Mei-Jun Zhang Ze-Xian Liu Yu-Xin Li Han-Qing Zhao Xue-Mei Li Xian-Dong He Yu Xue Meng-Qiu Dong |
| author_facet | Wen-Jun Li Chen-Wei Wang Li Tao Yong-Hong Yan Mei-Jun Zhang Ze-Xian Liu Yu-Xin Li Han-Qing Zhao Xue-Mei Li Xian-Dong He Yu Xue Meng-Qiu Dong |
| author_sort | Wen-Jun Li |
| collection | DOAJ |
| description | How phosphorylation mediated by Insulin/IGF-1 Signaling kinases regulates lifespan remains unclear. Here the authors perform a large-scale quantitative phosphoproteomic analysis of wildtype and IIS mutant C. elegans strains to reveal detailed functional insights into longevity. |
| first_indexed | 2024-12-23T03:30:51Z |
| format | Article |
| id | doaj.art-79b32e5ef67f4e64b5c54680fd9b724a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T03:30:51Z |
| publishDate | 2021-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-79b32e5ef67f4e64b5c54680fd9b724a2022-12-21T18:01:42ZengNature PortfolioNature Communications2041-17232021-07-0112111610.1038/s41467-021-24816-zInsulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegansWen-Jun Li0Chen-Wei Wang1Li Tao2Yong-Hong Yan3Mei-Jun Zhang4Ze-Xian Liu5Yu-Xin Li6Han-Qing Zhao7Xue-Mei Li8Xian-Dong He9Yu Xue10Meng-Qiu Dong11School of Life Sciences, Peking UniversityKey Laboratory of Molecular Biophysics of Ministry of Education, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Center for Artificial Intelligence Biology, College of Life Science and Technology, Huazhong University of Science and TechnologyNational Institute of Biological SciencesNational Institute of Biological SciencesNational Institute of Biological SciencesKey Laboratory of Molecular Biophysics of Ministry of Education, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Center for Artificial Intelligence Biology, College of Life Science and Technology, Huazhong University of Science and TechnologyNational Institute of Biological SciencesNational Institute of Biological SciencesSchool of Life Sciences, Peking UniversityNational Institute of Biological SciencesKey Laboratory of Molecular Biophysics of Ministry of Education, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Center for Artificial Intelligence Biology, College of Life Science and Technology, Huazhong University of Science and TechnologyNational Institute of Biological SciencesHow phosphorylation mediated by Insulin/IGF-1 Signaling kinases regulates lifespan remains unclear. Here the authors perform a large-scale quantitative phosphoproteomic analysis of wildtype and IIS mutant C. elegans strains to reveal detailed functional insights into longevity.https://doi.org/10.1038/s41467-021-24816-z |
| spellingShingle | Wen-Jun Li Chen-Wei Wang Li Tao Yong-Hong Yan Mei-Jun Zhang Ze-Xian Liu Yu-Xin Li Han-Qing Zhao Xue-Mei Li Xian-Dong He Yu Xue Meng-Qiu Dong Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans Nature Communications |
| title | Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans |
| title_full | Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans |
| title_fullStr | Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans |
| title_full_unstemmed | Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans |
| title_short | Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans |
| title_sort | insulin signaling regulates longevity through protein phosphorylation in caenorhabditis elegans |
| url | https://doi.org/10.1038/s41467-021-24816-z |
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