Maternal Death Due to Refractory Thrombotic Thrombocytopenic Purpura (TTP) Associated With Superimposed Preeclampsia, Sepsis, and Intracranial Hemorrhage: A Case Report
Thrombotic Thrombocytopenic Purpura (TTP) is an acute, rare, potentially life-threatening disorder presenting with thrombocytopenia, hemolytic anemia, and clinical consequences of microvascular thrombosis caused by a deficiency of ADAMS13 [1, 2]. The incidence of acquired TTP is approximately three...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2022-07-01
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| Series: | Case Reports in Clinical Practice |
| Subjects: | |
| Online Access: | https://crcp.tums.ac.ir/index.php/crcp/article/view/483 |
| _version_ | 1817970068999372800 |
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| author | Vajihe Marsusi Ashraf Sadat Jamal Maasoumeh Saleh Behnaz Nouri |
| author_facet | Vajihe Marsusi Ashraf Sadat Jamal Maasoumeh Saleh Behnaz Nouri |
| author_sort | Vajihe Marsusi |
| collection | DOAJ |
| description |
Thrombotic Thrombocytopenic Purpura (TTP) is an acute, rare, potentially life-threatening disorder presenting with thrombocytopenia, hemolytic anemia, and clinical consequences of microvascular thrombosis caused by a deficiency of ADAMS13 [1, 2]. The incidence of acquired TTP is approximately three cases per one million adults per year, based on the Oklahoma TTP-Hemolytic uremic syndrome (HUS) Registry [3]. Here, we present a case of TTP with persistent severely deficient ADAMS13 activity and recurrent relapses. She had a refractory relapse in the third trimester of pregnancy, complicated with superimposed severe preeclampsia and sepsis, and finally expired due to intracranial hemorrhage (ICH).
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| first_indexed | 2024-04-13T20:29:26Z |
| format | Article |
| id | doaj.art-79b3c8f1e6344427b5ee89d4e94752b7 |
| institution | Directory Open Access Journal |
| issn | 2538-2683 2538-2691 |
| language | English |
| last_indexed | 2024-04-13T20:29:26Z |
| publishDate | 2022-07-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Case Reports in Clinical Practice |
| spelling | doaj.art-79b3c8f1e6344427b5ee89d4e94752b72022-12-22T02:31:13ZengTehran University of Medical SciencesCase Reports in Clinical Practice2538-26832538-26912022-07-016S1Maternal Death Due to Refractory Thrombotic Thrombocytopenic Purpura (TTP) Associated With Superimposed Preeclampsia, Sepsis, and Intracranial Hemorrhage: A Case ReportVajihe Marsusi0Ashraf Sadat Jamal1Maasoumeh Saleh2Behnaz Nouri3Department of Obstetrics and Gynecology, Faculty of Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.Department of Obstetrics and Gynecology, Faculty of Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.Department of Obstetrics and Gynecology, Faculty of Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.Department of Obstetrics and Gynecology, Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran. Thrombotic Thrombocytopenic Purpura (TTP) is an acute, rare, potentially life-threatening disorder presenting with thrombocytopenia, hemolytic anemia, and clinical consequences of microvascular thrombosis caused by a deficiency of ADAMS13 [1, 2]. The incidence of acquired TTP is approximately three cases per one million adults per year, based on the Oklahoma TTP-Hemolytic uremic syndrome (HUS) Registry [3]. Here, we present a case of TTP with persistent severely deficient ADAMS13 activity and recurrent relapses. She had a refractory relapse in the third trimester of pregnancy, complicated with superimposed severe preeclampsia and sepsis, and finally expired due to intracranial hemorrhage (ICH). https://crcp.tums.ac.ir/index.php/crcp/article/view/483Thrombotic Thrombocytopenic PurpuraPregnancyPreeclampsiaPlasma exchangesepsis |
| spellingShingle | Vajihe Marsusi Ashraf Sadat Jamal Maasoumeh Saleh Behnaz Nouri Maternal Death Due to Refractory Thrombotic Thrombocytopenic Purpura (TTP) Associated With Superimposed Preeclampsia, Sepsis, and Intracranial Hemorrhage: A Case Report Case Reports in Clinical Practice Thrombotic Thrombocytopenic Purpura Pregnancy Preeclampsia Plasma exchange sepsis |
| title | Maternal Death Due to Refractory Thrombotic Thrombocytopenic Purpura (TTP) Associated With Superimposed Preeclampsia, Sepsis, and Intracranial Hemorrhage: A Case Report |
| title_full | Maternal Death Due to Refractory Thrombotic Thrombocytopenic Purpura (TTP) Associated With Superimposed Preeclampsia, Sepsis, and Intracranial Hemorrhage: A Case Report |
| title_fullStr | Maternal Death Due to Refractory Thrombotic Thrombocytopenic Purpura (TTP) Associated With Superimposed Preeclampsia, Sepsis, and Intracranial Hemorrhage: A Case Report |
| title_full_unstemmed | Maternal Death Due to Refractory Thrombotic Thrombocytopenic Purpura (TTP) Associated With Superimposed Preeclampsia, Sepsis, and Intracranial Hemorrhage: A Case Report |
| title_short | Maternal Death Due to Refractory Thrombotic Thrombocytopenic Purpura (TTP) Associated With Superimposed Preeclampsia, Sepsis, and Intracranial Hemorrhage: A Case Report |
| title_sort | maternal death due to refractory thrombotic thrombocytopenic purpura ttp associated with superimposed preeclampsia sepsis and intracranial hemorrhage a case report |
| topic | Thrombotic Thrombocytopenic Purpura Pregnancy Preeclampsia Plasma exchange sepsis |
| url | https://crcp.tums.ac.ir/index.php/crcp/article/view/483 |
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