Asperolide A, a Marine-Derived Tetranorditerpenoid, Induces G2/M Arrest in Human NCI-H460 Lung Carcinoma Cells, Is Mediated by p53-p21 Stabilization and Modulated by Ras/Raf/MEK/ERK Signaling Pathway

Asperolide A, a Marine-Derived Tetranorditerpenoid, Induces G2/M Arrest in Human NCI-H460 Lung Carcinoma Cells, Is Mediated by p53-p21 Stabilization and Modulated by Ras/Raf/MEK/ERK Signaling Pathway

Here we first demonstrate that asperolide A, a very recently reported marine-derived tetranorditerpenoid, leads to the inhibition of NCI-H460 lung carcinoma cell proliferation by G2/M arrest with the activation of the Ras/Raf/MEK/ERK signaling and p53-dependent p21 pathway. Treatment with 35 μM aspe...

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Bibliographic Details
Main Authors: Caiguo Huang, Bingui Wang, Ruohua Chen, Shanjian Wei, Haofen Sun, Cuiting Lv, Wenxia Sun
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:Marine Drugs
Subjects:
asperolide A
G2/M arrest
p53-p21
Ras/Raf/MEK/ERK signaling pathway
Online Access:http://www.mdpi.com/1660-3397/11/2/316

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