Examining the efficacy of a cardio-dance intervention on brain health and the moderating role of ABCA7 in older African Americans: a protocol for a randomized controlled trial
IntroductionAfrican Americans are two to three times more likely to be diagnosed with Alzheimer’s disease (AD) compared to White Americans. Exercise is a lifestyle behavior associated with neuroprotection and decreased AD risk, although most African Americans, especially older adults, perform less t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1266423/full |
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| author | Mark A. Gluck Joshua L. Gills Bernadette A. Fausto Steven K. Malin Paul R. Duberstein Kirk I. Erickson Liangyuan Hu |
| author_facet | Mark A. Gluck Joshua L. Gills Bernadette A. Fausto Steven K. Malin Paul R. Duberstein Kirk I. Erickson Liangyuan Hu |
| author_sort | Mark A. Gluck |
| collection | DOAJ |
| description | IntroductionAfrican Americans are two to three times more likely to be diagnosed with Alzheimer’s disease (AD) compared to White Americans. Exercise is a lifestyle behavior associated with neuroprotection and decreased AD risk, although most African Americans, especially older adults, perform less than the recommended 150 min/week of moderate-to-vigorous intensity exercise. This article describes the protocol for a Phase III randomized controlled trial that will examine the effects of cardio-dance aerobic exercise on novel AD cognitive and neural markers of hippocampal-dependent function (Aims #1 and #2) and whether exercise-induced neuroprotective benefits may be modulated by an AD genetic risk factor, ABCA7 rs3764650 (Aim #3). We will also explore the effects of exercise on blood-based biomarkers for AD.Methods and analysisThis 6-month trial will include 280 African Americans (≥ 60 years), who will be randomly assigned to 3 days/week of either: (1) a moderate-to-vigorous cardio-dance fitness condition or (2) a low-intensity strength, flexibility, and balance condition for 60 min/session. Participants will complete health and behavioral surveys, neuropsychological testing, saliva and venipuncture, aerobic fitness, anthropometrics and resting-state structural and functional neuroimaging at study entry and 6 months.DiscussionResults from this investigation will inform future exercise trials and the development of prescribed interventions that aim to reduce the risk of AD in African Americans. |
| first_indexed | 2024-03-10T00:40:22Z |
| format | Article |
| id | doaj.art-79b4f99278f0416ab202a8f1e7b59e8f |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-10T00:40:22Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-79b4f99278f0416ab202a8f1e7b59e8f2023-11-23T15:09:21ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-11-011510.3389/fnagi.2023.12664231266423Examining the efficacy of a cardio-dance intervention on brain health and the moderating role of ABCA7 in older African Americans: a protocol for a randomized controlled trialMark A. Gluck0Joshua L. Gills1Bernadette A. Fausto2Steven K. Malin3Paul R. Duberstein4Kirk I. Erickson5Liangyuan Hu6Center for Molecular and Behavioral Neuroscience, Rutgers University-Newark, Newark, NJ, United StatesCenter for Molecular and Behavioral Neuroscience, Rutgers University-Newark, Newark, NJ, United StatesCenter for Molecular and Behavioral Neuroscience, Rutgers University-Newark, Newark, NJ, United StatesDepartment of Kinesiology and Health, Rutgers University, New Brunswick, NJ, United StatesDepartment of Health Behavior, Society and Policy, Rutgers School of Public Health, Piscataway, NJ, United StatesAdventHealth Research Institute, Orlando, FL, United StatesDepartment of Biostatistics and Epidemiology, School of Public Health, Rutgers School of Public Health, Piscataway, NJ, United StatesIntroductionAfrican Americans are two to three times more likely to be diagnosed with Alzheimer’s disease (AD) compared to White Americans. Exercise is a lifestyle behavior associated with neuroprotection and decreased AD risk, although most African Americans, especially older adults, perform less than the recommended 150 min/week of moderate-to-vigorous intensity exercise. This article describes the protocol for a Phase III randomized controlled trial that will examine the effects of cardio-dance aerobic exercise on novel AD cognitive and neural markers of hippocampal-dependent function (Aims #1 and #2) and whether exercise-induced neuroprotective benefits may be modulated by an AD genetic risk factor, ABCA7 rs3764650 (Aim #3). We will also explore the effects of exercise on blood-based biomarkers for AD.Methods and analysisThis 6-month trial will include 280 African Americans (≥ 60 years), who will be randomly assigned to 3 days/week of either: (1) a moderate-to-vigorous cardio-dance fitness condition or (2) a low-intensity strength, flexibility, and balance condition for 60 min/session. Participants will complete health and behavioral surveys, neuropsychological testing, saliva and venipuncture, aerobic fitness, anthropometrics and resting-state structural and functional neuroimaging at study entry and 6 months.DiscussionResults from this investigation will inform future exercise trials and the development of prescribed interventions that aim to reduce the risk of AD in African Americans.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1266423/fullolder adultscognitionexercise interventionolder African Americanclinical trial |
| spellingShingle | Mark A. Gluck Joshua L. Gills Bernadette A. Fausto Steven K. Malin Paul R. Duberstein Kirk I. Erickson Liangyuan Hu Examining the efficacy of a cardio-dance intervention on brain health and the moderating role of ABCA7 in older African Americans: a protocol for a randomized controlled trial Frontiers in Aging Neuroscience older adults cognition exercise intervention older African American clinical trial |
| title | Examining the efficacy of a cardio-dance intervention on brain health and the moderating role of ABCA7 in older African Americans: a protocol for a randomized controlled trial |
| title_full | Examining the efficacy of a cardio-dance intervention on brain health and the moderating role of ABCA7 in older African Americans: a protocol for a randomized controlled trial |
| title_fullStr | Examining the efficacy of a cardio-dance intervention on brain health and the moderating role of ABCA7 in older African Americans: a protocol for a randomized controlled trial |
| title_full_unstemmed | Examining the efficacy of a cardio-dance intervention on brain health and the moderating role of ABCA7 in older African Americans: a protocol for a randomized controlled trial |
| title_short | Examining the efficacy of a cardio-dance intervention on brain health and the moderating role of ABCA7 in older African Americans: a protocol for a randomized controlled trial |
| title_sort | examining the efficacy of a cardio dance intervention on brain health and the moderating role of abca7 in older african americans a protocol for a randomized controlled trial |
| topic | older adults cognition exercise intervention older African American clinical trial |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1266423/full |
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