The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy
Tumors are composed of abnormally transformed cell types and tissues that differ from normal tissues in their genetic and epigenetic makeup, metabolism, and immunology. Molecular compounds that modulate the immune response against neoplasms offer promising new strategies to combat cancer. Inhibitors...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-01-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00151/full |
| _version_ | 1818583677254238208 |
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| author | Lilla Hornyák Nikoletta Dobos Gábor Koncz Zsolt Karányi Zsolt Karányi Dénes Páll Zoltán Szabó Gábor Halmos Lóránt Székvölgyi |
| author_facet | Lilla Hornyák Nikoletta Dobos Gábor Koncz Zsolt Karányi Zsolt Karányi Dénes Páll Zoltán Szabó Gábor Halmos Lóránt Székvölgyi |
| author_sort | Lilla Hornyák |
| collection | DOAJ |
| description | Tumors are composed of abnormally transformed cell types and tissues that differ from normal tissues in their genetic and epigenetic makeup, metabolism, and immunology. Molecular compounds that modulate the immune response against neoplasms offer promising new strategies to combat cancer. Inhibitors targeting the indoleamine-2,3-dioxygenase 1 enzyme (IDO1) represent one of the most potent therapeutic opportunities to inhibit tumor growth. Herein, we assess the biochemical role of IDO1 in tumor metabolism and immune surveillance, and review current diagnostic and therapeutic approaches that are intended to increase the effectiveness of immunotherapies against highly aggressive and difficult-to-treat IDO-expressing cancers. |
| first_indexed | 2024-12-16T08:09:05Z |
| format | Article |
| id | doaj.art-79b65779c4e64d13959f65cccb49db00 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-16T08:09:05Z |
| publishDate | 2018-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-79b65779c4e64d13959f65cccb49db002022-12-21T22:38:24ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-01-01910.3389/fimmu.2018.00151340144The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and TherapyLilla Hornyák0Nikoletta Dobos1Gábor Koncz2Zsolt Karányi3Zsolt Karányi4Dénes Páll5Zoltán Szabó6Gábor Halmos7Lóránt Székvölgyi8MTA-DE Momentum Genome Architecture and Recombination Research Group, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, HungaryDepartment of Biopharmacy, Faculty of Pharmacology, University of Debrecen, Debrecen, HungaryDepartment of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, HungaryMTA-DE Momentum Genome Architecture and Recombination Research Group, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, HungaryDepartment of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, HungaryDepartment of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, HungaryDepartment of Emergency Medicine, Faculty of Medicine, University of Debrecen, Debrecen, HungaryDepartment of Biopharmacy, Faculty of Pharmacology, University of Debrecen, Debrecen, HungaryMTA-DE Momentum Genome Architecture and Recombination Research Group, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, HungaryTumors are composed of abnormally transformed cell types and tissues that differ from normal tissues in their genetic and epigenetic makeup, metabolism, and immunology. Molecular compounds that modulate the immune response against neoplasms offer promising new strategies to combat cancer. Inhibitors targeting the indoleamine-2,3-dioxygenase 1 enzyme (IDO1) represent one of the most potent therapeutic opportunities to inhibit tumor growth. Herein, we assess the biochemical role of IDO1 in tumor metabolism and immune surveillance, and review current diagnostic and therapeutic approaches that are intended to increase the effectiveness of immunotherapies against highly aggressive and difficult-to-treat IDO-expressing cancers.http://journal.frontiersin.org/article/10.3389/fimmu.2018.00151/fullindoleamine-2,3-dioxygenasegene expressionmetabolismimmunotherapyimmune surveillancecancer diagnostics |
| spellingShingle | Lilla Hornyák Nikoletta Dobos Gábor Koncz Zsolt Karányi Zsolt Karányi Dénes Páll Zoltán Szabó Gábor Halmos Lóránt Székvölgyi The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy Frontiers in Immunology indoleamine-2,3-dioxygenase gene expression metabolism immunotherapy immune surveillance cancer diagnostics |
| title | The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy |
| title_full | The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy |
| title_fullStr | The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy |
| title_full_unstemmed | The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy |
| title_short | The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy |
| title_sort | role of indoleamine 2 3 dioxygenase in cancer development diagnostics and therapy |
| topic | indoleamine-2,3-dioxygenase gene expression metabolism immunotherapy immune surveillance cancer diagnostics |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00151/full |
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