Clinical Trials for Treatment and Prevention of HIV-Associated Malignancies in Sub-Saharan Africa: Building Capacity and Overcoming Barriers
PURPOSEThe aim of this study was to review the current status of clinical trials for HIV-associated malignancies in people living with HIV in sub-Saharan Africa (SSA) and efforts made by the AIDS Malignancy Consortium (AMC) to build capacity in SSA for HIV malignancy research.METHODSAll malignancy-r...
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| Format: | Article |
| Language: | English |
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American Society of Clinical Oncology
2020-11-01
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| Series: | JCO Global Oncology |
| Online Access: | https://ascopubs.org/doi/10.1200/GO.20.00153 |
| _version_ | 1818759794745409536 |
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| author | Lilie L. Lin David S. Lakomy Elizabeth Y. Chiao Robert M. Strother Meg Wirth Ethel Cesarman Margaret Borok Naftali Busakhala Carla J. Chibwesha Lameck Chinula Ntokozo Ndlovu Jackson Orem Warren Phipps Vikash Sewram Samantha L. Vogt Joseph A. Sparano Ronald T. Mitsuyasu Susan E. Krown Satish Gopal |
| author_facet | Lilie L. Lin David S. Lakomy Elizabeth Y. Chiao Robert M. Strother Meg Wirth Ethel Cesarman Margaret Borok Naftali Busakhala Carla J. Chibwesha Lameck Chinula Ntokozo Ndlovu Jackson Orem Warren Phipps Vikash Sewram Samantha L. Vogt Joseph A. Sparano Ronald T. Mitsuyasu Susan E. Krown Satish Gopal |
| author_sort | Lilie L. Lin |
| collection | DOAJ |
| description | PURPOSEThe aim of this study was to review the current status of clinical trials for HIV-associated malignancies in people living with HIV in sub-Saharan Africa (SSA) and efforts made by the AIDS Malignancy Consortium (AMC) to build capacity in SSA for HIV malignancy research.METHODSAll malignancy-related clinical trials in 49 SSA countries on ClinicalTrials.gov were reviewed and evaluated for inclusion and exclusion criteria pertaining to HIV status. Additional studies by AMC in SSA were compiled from Web-based resources, and narrative summaries were prepared to highlight AMC capacity building and training initiatives.RESULTSOf 96 cancer trials identified in SSA, only 11 focused specifically on people living with HIV, including studies in Kaposi sarcoma, cervical dysplasia and cancer, non-Hodgkin lymphoma, and ocular surface squamous neoplasia. Recognizing the increasing cancer burden in the region, AMC expanded its clinical trial activities to SSA in 2010, with 4 trials completed to date and 6 others in progress or development, and has made ongoing investments in developing research infrastructure in the region.CONCLUSIONAs the HIV-associated malignancy burden in SSA evolves, research into this domain has been limited. AMC, the only global HIV malignancy-focused research consortium, not only conducts vital HIV-associated malignancies research in SSA, but also develops pathology, personnel, and community-based infrastructure to meet these challenges in SSA. Nonetheless, there is an ongoing need to build on these efforts to improve HIV-associated malignancies outcomes in SSA. |
| first_indexed | 2024-12-18T06:48:23Z |
| format | Article |
| id | doaj.art-79b9238cbebd496bbde3be934652fcc7 |
| institution | Directory Open Access Journal |
| issn | 2687-8941 |
| language | English |
| last_indexed | 2024-12-18T06:48:23Z |
| publishDate | 2020-11-01 |
| publisher | American Society of Clinical Oncology |
| record_format | Article |
| series | JCO Global Oncology |
| spelling | doaj.art-79b9238cbebd496bbde3be934652fcc72022-12-21T21:17:25ZengAmerican Society of Clinical OncologyJCO Global Oncology2687-89412020-11-0161134114610.1200/GO.20.00153Clinical Trials for Treatment and Prevention of HIV-Associated Malignancies in Sub-Saharan Africa: Building Capacity and Overcoming BarriersLilie L. Lin0David S. Lakomy1Elizabeth Y. Chiao2Robert M. Strother3Meg Wirth4Ethel Cesarman5Margaret Borok6Naftali Busakhala7Carla J. Chibwesha8Lameck Chinula9Ntokozo Ndlovu10Jackson Orem11Warren Phipps12Vikash Sewram13Samantha L. Vogt14Joseph A. Sparano15Ronald T. Mitsuyasu16Susan E. Krown17Satish Gopal18Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TXDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TXDepartment of General Oncology, The University of Texas MD Anderson Cancer Center, Houston, TXDepartment of Medicine, University of Otago, Christchurch, New ZealandThe Emmes Corporation, Callaway, MDDepartment of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NYDepartment of Medicine, University of Zimbabwe College of Health Sciences, Harare, ZimbabweDepartment of Pharmacology and Toxicology, Moi University School of Medicine, Eldoret, KenyaInstitute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NCDivision of Global Women’s Health, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NCDepartment of Radiology, University of Zimbabwe College of Health Sciences, Harare, ZimbabweUganda Cancer Institute, Kampala, UgandaUganda Cancer Institute, Kampala, UgandaAfrican Cancer Institute, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South AfricaDepartment of Medical Oncology, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MDMontefiore-Einstein Cancer Center, Montefiore Medical Center, Bronx, NYCenter for Clinical AIDS Research and Education, University of California, Los Angeles, Los Angeles, CAAIDS Malignancy Consortium, New York, NYCenter for Global Health, National Cancer Institute, Rockville, MDPURPOSEThe aim of this study was to review the current status of clinical trials for HIV-associated malignancies in people living with HIV in sub-Saharan Africa (SSA) and efforts made by the AIDS Malignancy Consortium (AMC) to build capacity in SSA for HIV malignancy research.METHODSAll malignancy-related clinical trials in 49 SSA countries on ClinicalTrials.gov were reviewed and evaluated for inclusion and exclusion criteria pertaining to HIV status. Additional studies by AMC in SSA were compiled from Web-based resources, and narrative summaries were prepared to highlight AMC capacity building and training initiatives.RESULTSOf 96 cancer trials identified in SSA, only 11 focused specifically on people living with HIV, including studies in Kaposi sarcoma, cervical dysplasia and cancer, non-Hodgkin lymphoma, and ocular surface squamous neoplasia. Recognizing the increasing cancer burden in the region, AMC expanded its clinical trial activities to SSA in 2010, with 4 trials completed to date and 6 others in progress or development, and has made ongoing investments in developing research infrastructure in the region.CONCLUSIONAs the HIV-associated malignancy burden in SSA evolves, research into this domain has been limited. AMC, the only global HIV malignancy-focused research consortium, not only conducts vital HIV-associated malignancies research in SSA, but also develops pathology, personnel, and community-based infrastructure to meet these challenges in SSA. Nonetheless, there is an ongoing need to build on these efforts to improve HIV-associated malignancies outcomes in SSA.https://ascopubs.org/doi/10.1200/GO.20.00153 |
| spellingShingle | Lilie L. Lin David S. Lakomy Elizabeth Y. Chiao Robert M. Strother Meg Wirth Ethel Cesarman Margaret Borok Naftali Busakhala Carla J. Chibwesha Lameck Chinula Ntokozo Ndlovu Jackson Orem Warren Phipps Vikash Sewram Samantha L. Vogt Joseph A. Sparano Ronald T. Mitsuyasu Susan E. Krown Satish Gopal Clinical Trials for Treatment and Prevention of HIV-Associated Malignancies in Sub-Saharan Africa: Building Capacity and Overcoming Barriers JCO Global Oncology |
| title | Clinical Trials for Treatment and Prevention of HIV-Associated Malignancies in Sub-Saharan Africa: Building Capacity and Overcoming Barriers |
| title_full | Clinical Trials for Treatment and Prevention of HIV-Associated Malignancies in Sub-Saharan Africa: Building Capacity and Overcoming Barriers |
| title_fullStr | Clinical Trials for Treatment and Prevention of HIV-Associated Malignancies in Sub-Saharan Africa: Building Capacity and Overcoming Barriers |
| title_full_unstemmed | Clinical Trials for Treatment and Prevention of HIV-Associated Malignancies in Sub-Saharan Africa: Building Capacity and Overcoming Barriers |
| title_short | Clinical Trials for Treatment and Prevention of HIV-Associated Malignancies in Sub-Saharan Africa: Building Capacity and Overcoming Barriers |
| title_sort | clinical trials for treatment and prevention of hiv associated malignancies in sub saharan africa building capacity and overcoming barriers |
| url | https://ascopubs.org/doi/10.1200/GO.20.00153 |
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