Plasma extracellular vesicle messenger RNA profiling identifies prognostic EV signature for non-invasive risk stratification for survival prediction of patients with pancreatic ductal adenocarcinoma

Plasma extracellular vesicle messenger RNA profiling identifies prognostic EV signature for non-invasive risk stratification for survival prediction of patients with pancreatic ductal adenocarcinoma

Abstract Background The prognosis of pancreatic ductal adenocarcinoma (PDAC) is one of the most dismal of all cancers and the median survival of PDAC patients is only 6–8 months after diagnosis. While decades of research effort have been focused on early diagnosis and understanding of molecular mech...

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Bibliographic Details
Main Authors: Yi Han, Pascal Drobisch, Alexander Krüger, Doreen William, Konrad Grützmann, Lukas Böthig, Heike Polster, Lena Seifert, Adrian M. Seifert, Marius Distler, Mathieu Pecqueux, Carina Riediger, Verena Plodeck, Heiner Nebelung, Georg F. Weber, Christian Pilarsky, Ulf Kahlert, Ulf Hinz, Susanne Roth, Thilo Hackert, Jürgen Weitz, Fang Cheng Wong, Christoph Kahlert
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Journal of Hematology & Oncology
Subjects:
Extracellular vesicles
Pancreatic ductal adenocarcinoma
Prognosis
Plasma extracellular vesicle
mRNA biomarkers
Online Access:https://doi.org/10.1186/s13045-023-01404-w

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