SIRT1 Allele Frequencies in Depressed Patients of European Descent in Russia
Depressive disorder (DD) is a widespread mental disorder. Although DD is to some extent inherited, the genes contributing to the risk of this disorder and its genetic mechanisms remain poorly understood. A recent large-scale genome-wide association Chinese study revealed a strong association between...
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Frontiers Media S.A.
2019-01-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fgene.2018.00686/full |
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| author | Lyubomir I. Aftanas Lyubomir I. Aftanas Maksim S. Anisimenko Darya A. Berdyugina Aleksandr Yu. Garanin Vladimir N. Maximov Mikhail I. Voevoda Natalya M. Vyalova Nikolay A. Bokhan Nikolay A. Bokhan Svetlana A. Ivanova Svetlana A. Ivanova Konstantin V. Danilenko Konstantin V. Danilenko Sergei P. Kovalenko Sergei P. Kovalenko |
| author_facet | Lyubomir I. Aftanas Lyubomir I. Aftanas Maksim S. Anisimenko Darya A. Berdyugina Aleksandr Yu. Garanin Vladimir N. Maximov Mikhail I. Voevoda Natalya M. Vyalova Nikolay A. Bokhan Nikolay A. Bokhan Svetlana A. Ivanova Svetlana A. Ivanova Konstantin V. Danilenko Konstantin V. Danilenko Sergei P. Kovalenko Sergei P. Kovalenko |
| author_sort | Lyubomir I. Aftanas |
| collection | DOAJ |
| description | Depressive disorder (DD) is a widespread mental disorder. Although DD is to some extent inherited, the genes contributing to the risk of this disorder and its genetic mechanisms remain poorly understood. A recent large-scale genome-wide association Chinese study revealed a strong association between the SIRT1 gene variants and DD. The aim of this study was to analyze the occurrence of heterozygote carriers and search for rare SNP variants of the SIRT1 gene in a cohort of DD patients as compared with a cohort of randomly selected members of the Russian population. The complete coding sequences of the SIRT1 gene from 1024 DNA samples from the general Russian population and from 244 samples from patients with DD were analyzed using targeted sequencing. Four new genetic variants of the SIRT1 were discovered. While no significant differences in the allele frequencies were found between the DD patients and the general population, differences between the frequencies of homozygote carriers of specific alleles and occurrences of heterozygous were found to be significant for rs2236318 (P < 0.0001), and putatively, rs7896005 (P < 0.05), and rs36107781 (P < 0.05). The study found for the first time that two new SNPs (i.e., 10:69665829 and 10:69665971) along with recently reported ones (rs773025707 and rs34701705), are putatively associated with DD. The revealed DD-associated SIRT1 SNPs might confer susceptibility to this disorder in Russian population of European descent. |
| first_indexed | 2024-12-19T13:08:22Z |
| format | Article |
| id | doaj.art-79bb92b97a8449f8abc3e13a09d5a214 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-19T13:08:22Z |
| publishDate | 2019-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-79bb92b97a8449f8abc3e13a09d5a2142022-12-21T20:19:59ZengFrontiers Media S.A.Frontiers in Genetics1664-80212019-01-01910.3389/fgene.2018.00686417408SIRT1 Allele Frequencies in Depressed Patients of European Descent in RussiaLyubomir I. Aftanas0Lyubomir I. Aftanas1Maksim S. Anisimenko2Darya A. Berdyugina3Aleksandr Yu. Garanin4Vladimir N. Maximov5Mikhail I. Voevoda6Natalya M. Vyalova7Nikolay A. Bokhan8Nikolay A. Bokhan9Svetlana A. Ivanova10Svetlana A. Ivanova11Konstantin V. Danilenko12Konstantin V. Danilenko13Sergei P. Kovalenko14Sergei P. Kovalenko15Institute of Physiology and Basic Medicine, Novosibirsk, RussiaInstitute of Medicine and Psychology, Novosibirsk State University, Novosibirsk, RussiaInstitute of Physiology and Basic Medicine, Novosibirsk, RussiaInstitute of Physiology and Basic Medicine, Novosibirsk, RussiaInstitute of Physiology and Basic Medicine, Novosibirsk, RussiaInstitute of Cytology and Genetics, Novosibirsk, RussiaInstitute of Cytology and Genetics, Novosibirsk, RussiaTomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute, Tomsk, RussiaTomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute, Tomsk, RussiaDepartment of Psychotherapy and Psychological Counseling, National Research Tomsk State University, Tomsk, RussiaTomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute, Tomsk, RussiaInstitute of Non-Destructive Testing, National Research Tomsk Polytechnic University, Tomsk, RussiaInstitute of Physiology and Basic Medicine, Novosibirsk, RussiaInstitute of Medicine and Psychology, Novosibirsk State University, Novosibirsk, RussiaInstitute of Physiology and Basic Medicine, Novosibirsk, RussiaInstitute of Medicine and Psychology, Novosibirsk State University, Novosibirsk, RussiaDepressive disorder (DD) is a widespread mental disorder. Although DD is to some extent inherited, the genes contributing to the risk of this disorder and its genetic mechanisms remain poorly understood. A recent large-scale genome-wide association Chinese study revealed a strong association between the SIRT1 gene variants and DD. The aim of this study was to analyze the occurrence of heterozygote carriers and search for rare SNP variants of the SIRT1 gene in a cohort of DD patients as compared with a cohort of randomly selected members of the Russian population. The complete coding sequences of the SIRT1 gene from 1024 DNA samples from the general Russian population and from 244 samples from patients with DD were analyzed using targeted sequencing. Four new genetic variants of the SIRT1 were discovered. While no significant differences in the allele frequencies were found between the DD patients and the general population, differences between the frequencies of homozygote carriers of specific alleles and occurrences of heterozygous were found to be significant for rs2236318 (P < 0.0001), and putatively, rs7896005 (P < 0.05), and rs36107781 (P < 0.05). The study found for the first time that two new SNPs (i.e., 10:69665829 and 10:69665971) along with recently reported ones (rs773025707 and rs34701705), are putatively associated with DD. The revealed DD-associated SIRT1 SNPs might confer susceptibility to this disorder in Russian population of European descent.https://www.frontiersin.org/article/10.3389/fgene.2018.00686/fullSIRT1 geneSNPdepressive disorderspopulationEuropean descent |
| spellingShingle | Lyubomir I. Aftanas Lyubomir I. Aftanas Maksim S. Anisimenko Darya A. Berdyugina Aleksandr Yu. Garanin Vladimir N. Maximov Mikhail I. Voevoda Natalya M. Vyalova Nikolay A. Bokhan Nikolay A. Bokhan Svetlana A. Ivanova Svetlana A. Ivanova Konstantin V. Danilenko Konstantin V. Danilenko Sergei P. Kovalenko Sergei P. Kovalenko SIRT1 Allele Frequencies in Depressed Patients of European Descent in Russia Frontiers in Genetics SIRT1 gene SNP depressive disorders population European descent |
| title | SIRT1 Allele Frequencies in Depressed Patients of European Descent in Russia |
| title_full | SIRT1 Allele Frequencies in Depressed Patients of European Descent in Russia |
| title_fullStr | SIRT1 Allele Frequencies in Depressed Patients of European Descent in Russia |
| title_full_unstemmed | SIRT1 Allele Frequencies in Depressed Patients of European Descent in Russia |
| title_short | SIRT1 Allele Frequencies in Depressed Patients of European Descent in Russia |
| title_sort | sirt1 allele frequencies in depressed patients of european descent in russia |
| topic | SIRT1 gene SNP depressive disorders population European descent |
| url | https://www.frontiersin.org/article/10.3389/fgene.2018.00686/full |
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