Cutaneous Granulomatosis Revealing Whipple’s Disease: Value of <i>Tropheryma whipplei</i> Polymerase Chain Reaction Assay for the Diagnosis
Whipple’s Disease is a rare systemic infectious disease caused by the ubiquitous actinomycetes <i>Tropheryma whipplei (T. whipplei).</i> We report herein a rare case of a cutaneous granulo matosis with hypercalcemia as an unusual presenting feature of Whipple’s disease. The diagnosis of...
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| Format: | Article |
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MDPI AG
2021-11-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/10/11/1438 |
| _version_ | 1797508870995705856 |
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| author | Souheil Zayet Pierre Isnard Jacinta Bustamante David Boutboul Sarra Abroug Nabil Belfeki |
| author_facet | Souheil Zayet Pierre Isnard Jacinta Bustamante David Boutboul Sarra Abroug Nabil Belfeki |
| author_sort | Souheil Zayet |
| collection | DOAJ |
| description | Whipple’s Disease is a rare systemic infectious disease caused by the ubiquitous actinomycetes <i>Tropheryma whipplei (T. whipplei).</i> We report herein a rare case of a cutaneous granulo matosis with hypercalcemia as an unusual presenting feature of Whipple’s disease. The diagnosis of the bacteria was obtained from skin and inguinal lymph node biopsy (16 rDNA PCR screening and histological examination using PAS staining). <i>T. whipplei</i> was also identified on saliva and stool specimens, using specific PCR and colonic biopsies. Treatment with hydroxychloroquine and doxycycline allowed a rapid resolution of symptoms with a complete recovery. |
| first_indexed | 2024-03-10T05:10:01Z |
| format | Article |
| id | doaj.art-79bbc827868243a6926c4667e23e1e67 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T05:10:01Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-79bbc827868243a6926c4667e23e1e672023-11-23T00:53:18ZengMDPI AGPathogens2076-08172021-11-011011143810.3390/pathogens10111438Cutaneous Granulomatosis Revealing Whipple’s Disease: Value of <i>Tropheryma whipplei</i> Polymerase Chain Reaction Assay for the DiagnosisSouheil Zayet0Pierre Isnard1Jacinta Bustamante2David Boutboul3Sarra Abroug4Nabil Belfeki5Department of Infectious Diseases, Nord Franche-Comté Hospital, 90400 Trévenans, FranceDepartment of Pathology, Necker Hospital for Sick Children, Assistance Publique des Hopitaux de Paris (Ap-HP), 75015 Paris, FranceDepartment of Cellular Biology, University of Paris, 75105 Paris, FranceDepartment of Clinical Immunology, Saint Louis Hospital, Assistance Publique des Hôpitaux de Paris, University of Paris, 75010 Paris, FranceDepartment of Internal Medicine, Groupe Hospitalier Sud Ile de France, 77000 Melun, FranceDepartment of Internal Medicine, Groupe Hospitalier Sud Ile de France, 77000 Melun, FranceWhipple’s Disease is a rare systemic infectious disease caused by the ubiquitous actinomycetes <i>Tropheryma whipplei (T. whipplei).</i> We report herein a rare case of a cutaneous granulo matosis with hypercalcemia as an unusual presenting feature of Whipple’s disease. The diagnosis of the bacteria was obtained from skin and inguinal lymph node biopsy (16 rDNA PCR screening and histological examination using PAS staining). <i>T. whipplei</i> was also identified on saliva and stool specimens, using specific PCR and colonic biopsies. Treatment with hydroxychloroquine and doxycycline allowed a rapid resolution of symptoms with a complete recovery.https://www.mdpi.com/2076-0817/10/11/1438granulomatosispolymerase chain reactionskinWhipple’s disease<i>Tropheryma whipplei</i> |
| spellingShingle | Souheil Zayet Pierre Isnard Jacinta Bustamante David Boutboul Sarra Abroug Nabil Belfeki Cutaneous Granulomatosis Revealing Whipple’s Disease: Value of <i>Tropheryma whipplei</i> Polymerase Chain Reaction Assay for the Diagnosis Pathogens granulomatosis polymerase chain reaction skin Whipple’s disease <i>Tropheryma whipplei</i> |
| title | Cutaneous Granulomatosis Revealing Whipple’s Disease: Value of <i>Tropheryma whipplei</i> Polymerase Chain Reaction Assay for the Diagnosis |
| title_full | Cutaneous Granulomatosis Revealing Whipple’s Disease: Value of <i>Tropheryma whipplei</i> Polymerase Chain Reaction Assay for the Diagnosis |
| title_fullStr | Cutaneous Granulomatosis Revealing Whipple’s Disease: Value of <i>Tropheryma whipplei</i> Polymerase Chain Reaction Assay for the Diagnosis |
| title_full_unstemmed | Cutaneous Granulomatosis Revealing Whipple’s Disease: Value of <i>Tropheryma whipplei</i> Polymerase Chain Reaction Assay for the Diagnosis |
| title_short | Cutaneous Granulomatosis Revealing Whipple’s Disease: Value of <i>Tropheryma whipplei</i> Polymerase Chain Reaction Assay for the Diagnosis |
| title_sort | cutaneous granulomatosis revealing whipple s disease value of i tropheryma whipplei i polymerase chain reaction assay for the diagnosis |
| topic | granulomatosis polymerase chain reaction skin Whipple’s disease <i>Tropheryma whipplei</i> |
| url | https://www.mdpi.com/2076-0817/10/11/1438 |
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