The role of serum tenascin-c and procalcitonin in predicting the severity of acute pancreatitis
Acute pancreatitis (AP) constitutes an activation of a variety of enzymes secreted by the pancreas and is a continuing inflammatory process where the pancreas damages itself. Although a variety of factors reported to have an association with disease severity, the role of Tenascin-C and procalcitonin...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Society of Turaz Bilim
2021-06-01
|
| Series: | Medicine Science |
| Subjects: | |
| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=16493 |
| _version_ | 1797328529020420096 |
|---|---|
| author | Adil Ugur Cetin Fatih Kamis Ece Unal Cetin Mehmet Arslan Yavuz Beyazit |
| author_facet | Adil Ugur Cetin Fatih Kamis Ece Unal Cetin Mehmet Arslan Yavuz Beyazit |
| author_sort | Adil Ugur Cetin |
| collection | DOAJ |
| description | Acute pancreatitis (AP) constitutes an activation of a variety of enzymes secreted by the pancreas and is a continuing inflammatory process where the pancreas damages itself. Although a variety of factors reported to have an association with disease severity, the role of Tenascin-C and procalcitonin in the pathophsiology of the disease has not been clearly elucidated yet. Therefore, this study aimed to assess whether tenascin-C and procalcitonin would be useful in predicting disease severity and prolonged hospital stay in conjunction with several prognostic scoring systems. A total of 44 AP patients (male/female: 24/20), and 40 healthy subjects (male/female: 20/20) were enrolled in this study. Tenascin-C and procalcitonin levels with other markers of inflammation were measured for all study participants. Prognostic scoring systems were used as to predict the disease severity in AP patients. Serum tenascin-C levels was higher in AP patients at onset of the disease compared with healthy controls. There were statistically significant and positive differences identified between serum Tenascin-C with Atlanta (p=0.000 r=0.538), Ranson (p=0.041 r=0.310) and Imrie (p=0.039 r=0.312) scoring systems. There was a statistically significant and positive correlation between CRP with serum tenascin-C (p=0.015 r=0,366) levels. Serum tenascin-C levels had high sensitivity (76.5%) and specificity (77.8%) for prediction of severe pancreatitis according to the Atlanta scoring system (AUC:0.809). The present study demonstrated that tenascin-C and procalcition levels are elevated in AP. Moreover, the appraisal of tenascin-C levels in patients with AP in conjunction with other markers of inflammation may provide additional information in estimating AP severity. [Med-Science 2021; 10(2.000): 493-7] |
| first_indexed | 2024-03-08T06:53:04Z |
| format | Article |
| id | doaj.art-79bccc113c8345b9b3a6165cb86d2eec |
| institution | Directory Open Access Journal |
| issn | 2147-0634 |
| language | English |
| last_indexed | 2024-03-08T06:53:04Z |
| publishDate | 2021-06-01 |
| publisher | Society of Turaz Bilim |
| record_format | Article |
| series | Medicine Science |
| spelling | doaj.art-79bccc113c8345b9b3a6165cb86d2eec2024-02-03T06:40:29ZengSociety of Turaz BilimMedicine Science2147-06342021-06-01102493710.5455/medscience.2020.12.25116493The role of serum tenascin-c and procalcitonin in predicting the severity of acute pancreatitisAdil Ugur Cetin0Fatih Kamis1Ece Unal Cetin2Mehmet Arslan3Yavuz Beyazit4Department of Internal Medicine, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey Department of Internal Medicine, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey Department of Internal Medicine, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey Department of Cardiology, Canakkale Mehmet Akif Ersoy State Hospital, Canakkale, Turkey Department of Internal Medicine, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, TurkeyAcute pancreatitis (AP) constitutes an activation of a variety of enzymes secreted by the pancreas and is a continuing inflammatory process where the pancreas damages itself. Although a variety of factors reported to have an association with disease severity, the role of Tenascin-C and procalcitonin in the pathophsiology of the disease has not been clearly elucidated yet. Therefore, this study aimed to assess whether tenascin-C and procalcitonin would be useful in predicting disease severity and prolonged hospital stay in conjunction with several prognostic scoring systems. A total of 44 AP patients (male/female: 24/20), and 40 healthy subjects (male/female: 20/20) were enrolled in this study. Tenascin-C and procalcitonin levels with other markers of inflammation were measured for all study participants. Prognostic scoring systems were used as to predict the disease severity in AP patients. Serum tenascin-C levels was higher in AP patients at onset of the disease compared with healthy controls. There were statistically significant and positive differences identified between serum Tenascin-C with Atlanta (p=0.000 r=0.538), Ranson (p=0.041 r=0.310) and Imrie (p=0.039 r=0.312) scoring systems. There was a statistically significant and positive correlation between CRP with serum tenascin-C (p=0.015 r=0,366) levels. Serum tenascin-C levels had high sensitivity (76.5%) and specificity (77.8%) for prediction of severe pancreatitis according to the Atlanta scoring system (AUC:0.809). The present study demonstrated that tenascin-C and procalcition levels are elevated in AP. Moreover, the appraisal of tenascin-C levels in patients with AP in conjunction with other markers of inflammation may provide additional information in estimating AP severity. [Med-Science 2021; 10(2.000): 493-7]http://www.ejmanager.com/fulltextpdf.php?mno=16493acute pancreatitistenascin-cprocalcitoninprognostic markers |
| spellingShingle | Adil Ugur Cetin Fatih Kamis Ece Unal Cetin Mehmet Arslan Yavuz Beyazit The role of serum tenascin-c and procalcitonin in predicting the severity of acute pancreatitis Medicine Science acute pancreatitis tenascin-c procalcitonin prognostic markers |
| title | The role of serum tenascin-c and procalcitonin in predicting the severity of acute pancreatitis |
| title_full | The role of serum tenascin-c and procalcitonin in predicting the severity of acute pancreatitis |
| title_fullStr | The role of serum tenascin-c and procalcitonin in predicting the severity of acute pancreatitis |
| title_full_unstemmed | The role of serum tenascin-c and procalcitonin in predicting the severity of acute pancreatitis |
| title_short | The role of serum tenascin-c and procalcitonin in predicting the severity of acute pancreatitis |
| title_sort | role of serum tenascin c and procalcitonin in predicting the severity of acute pancreatitis |
| topic | acute pancreatitis tenascin-c procalcitonin prognostic markers |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=16493 |
| work_keys_str_mv | AT adilugurcetin theroleofserumtenascincandprocalcitonininpredictingtheseverityofacutepancreatitis AT fatihkamis theroleofserumtenascincandprocalcitonininpredictingtheseverityofacutepancreatitis AT eceunalcetin theroleofserumtenascincandprocalcitonininpredictingtheseverityofacutepancreatitis AT mehmetarslan theroleofserumtenascincandprocalcitonininpredictingtheseverityofacutepancreatitis AT yavuzbeyazit theroleofserumtenascincandprocalcitonininpredictingtheseverityofacutepancreatitis AT adilugurcetin roleofserumtenascincandprocalcitonininpredictingtheseverityofacutepancreatitis AT fatihkamis roleofserumtenascincandprocalcitonininpredictingtheseverityofacutepancreatitis AT eceunalcetin roleofserumtenascincandprocalcitonininpredictingtheseverityofacutepancreatitis AT mehmetarslan roleofserumtenascincandprocalcitonininpredictingtheseverityofacutepancreatitis AT yavuzbeyazit roleofserumtenascincandprocalcitonininpredictingtheseverityofacutepancreatitis |