Effects of post-training administration of LY341495, as an mGluR2/3 antagonist on spatial memory deficit in rats fed with high-fat diet
High-fat diets (HFDs) adversely influence glutamate metabolism and neurotransmission. The precise role of the group II metabotropic glutamate receptors (mGluR2/3) antagonist on spatial memory deficit following consumption of HFD has not yet been clarified. Therefore, in this study, we examined the e...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | IBRO Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S245183012030039X |
| _version_ | 1818352465921179648 |
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| author | Heresh Moridi Abdolrahman Sarihi Elahe Habibitabar Hossein Shateri Iraj Salehi Alireza Komaki Jamshid Karimi Seyed Asaad Karimi |
| author_facet | Heresh Moridi Abdolrahman Sarihi Elahe Habibitabar Hossein Shateri Iraj Salehi Alireza Komaki Jamshid Karimi Seyed Asaad Karimi |
| author_sort | Heresh Moridi |
| collection | DOAJ |
| description | High-fat diets (HFDs) adversely influence glutamate metabolism and neurotransmission. The precise role of the group II metabotropic glutamate receptors (mGluR2/3) antagonist on spatial memory deficit following consumption of HFD has not yet been clarified. Therefore, in this study, we examined the effects of post-training administration of mGluR2/3 antagonism; LY341495 on spatial memory in rats fed with HFD (for 10 weeks) by using Morris Water Maze (MWM) task. The training session for testing memory acquisition in MWM consisted of 4 trials per day for 4 consecutive days. Twenty-four hours after the last training session the spatial probe test (retention) was given. Intraperitoneal injection (i.p) injection of LY341495 was done 30 min before probe test. Our results showed that 10 weeks consumption of HFD had no significant effect on escape latency and swimming distance in memory acquisition. Our finding showed that consumption of a HFD leads to reference memory impairment in the probe test. HFD animals spent less time in the target zone in compare with control animals. Also, LY341495 improved HFD-induced reference memory (retention) impairment. HFD animals treated with LY341495 spent more time in the target zone in compare with HFD animals. Escape latencies to find the visible platform during visual task were same in all experimental groups, indicating no visual impairment in the animals. We propose that a HFD may act through mGluR2/3 within the brain to reduce synaptic plasticity, which impairs memory retrieval, and post-training administration of LY341495 can reduce HFD-induced reference memory impairment. |
| first_indexed | 2024-12-13T18:54:04Z |
| format | Article |
| id | doaj.art-79bcd92639ad44d781167baedb3d968d |
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| issn | 2451-8301 |
| language | English |
| last_indexed | 2024-12-13T18:54:04Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Reports |
| spelling | doaj.art-79bcd92639ad44d781167baedb3d968d2022-12-21T23:34:51ZengElsevierIBRO Reports2451-83012020-12-019241246Effects of post-training administration of LY341495, as an mGluR2/3 antagonist on spatial memory deficit in rats fed with high-fat dietHeresh Moridi0Abdolrahman Sarihi1Elahe Habibitabar2Hossein Shateri3Iraj Salehi4Alireza Komaki5Jamshid Karimi6Seyed Asaad Karimi7Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran; Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IranNeurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; Department of Neuroscience, School of Science and Advanced Technologies in Medicine, Hamadan University of Medical Sciences, Hamadan, IranStudent Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran; Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IranStudent Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran; Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IranNeurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; Department of Neuroscience, School of Science and Advanced Technologies in Medicine, Hamadan University of Medical Sciences, Hamadan, IranNeurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; Department of Neuroscience, School of Science and Advanced Technologies in Medicine, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IranNeurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; Department of Neuroscience, School of Science and Advanced Technologies in Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; Corresponding author at: Neurophysiology Research Center, Hamadan University of Medical Sciences, Shahid Fahmideh Street, Hamadan, Postal Code: 65178/518, Iran.High-fat diets (HFDs) adversely influence glutamate metabolism and neurotransmission. The precise role of the group II metabotropic glutamate receptors (mGluR2/3) antagonist on spatial memory deficit following consumption of HFD has not yet been clarified. Therefore, in this study, we examined the effects of post-training administration of mGluR2/3 antagonism; LY341495 on spatial memory in rats fed with HFD (for 10 weeks) by using Morris Water Maze (MWM) task. The training session for testing memory acquisition in MWM consisted of 4 trials per day for 4 consecutive days. Twenty-four hours after the last training session the spatial probe test (retention) was given. Intraperitoneal injection (i.p) injection of LY341495 was done 30 min before probe test. Our results showed that 10 weeks consumption of HFD had no significant effect on escape latency and swimming distance in memory acquisition. Our finding showed that consumption of a HFD leads to reference memory impairment in the probe test. HFD animals spent less time in the target zone in compare with control animals. Also, LY341495 improved HFD-induced reference memory (retention) impairment. HFD animals treated with LY341495 spent more time in the target zone in compare with HFD animals. Escape latencies to find the visible platform during visual task were same in all experimental groups, indicating no visual impairment in the animals. We propose that a HFD may act through mGluR2/3 within the brain to reduce synaptic plasticity, which impairs memory retrieval, and post-training administration of LY341495 can reduce HFD-induced reference memory impairment.http://www.sciencedirect.com/science/article/pii/S245183012030039XMetabotropic Glutamate Receptors (mGluR2/3)LY341495Spatial memoryHigh-fat dietsRat |
| spellingShingle | Heresh Moridi Abdolrahman Sarihi Elahe Habibitabar Hossein Shateri Iraj Salehi Alireza Komaki Jamshid Karimi Seyed Asaad Karimi Effects of post-training administration of LY341495, as an mGluR2/3 antagonist on spatial memory deficit in rats fed with high-fat diet IBRO Reports Metabotropic Glutamate Receptors (mGluR2/3) LY341495 Spatial memory High-fat diets Rat |
| title | Effects of post-training administration of LY341495, as an mGluR2/3 antagonist on spatial memory deficit in rats fed with high-fat diet |
| title_full | Effects of post-training administration of LY341495, as an mGluR2/3 antagonist on spatial memory deficit in rats fed with high-fat diet |
| title_fullStr | Effects of post-training administration of LY341495, as an mGluR2/3 antagonist on spatial memory deficit in rats fed with high-fat diet |
| title_full_unstemmed | Effects of post-training administration of LY341495, as an mGluR2/3 antagonist on spatial memory deficit in rats fed with high-fat diet |
| title_short | Effects of post-training administration of LY341495, as an mGluR2/3 antagonist on spatial memory deficit in rats fed with high-fat diet |
| title_sort | effects of post training administration of ly341495 as an mglur2 3 antagonist on spatial memory deficit in rats fed with high fat diet |
| topic | Metabotropic Glutamate Receptors (mGluR2/3) LY341495 Spatial memory High-fat diets Rat |
| url | http://www.sciencedirect.com/science/article/pii/S245183012030039X |
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