Cytological Features That Differentiate Follicular Neoplasm from Mimicking Lesions
Background It is difficult to correctly diagnose follicular neoplasms (FNs) on fine-needle aspiration cytology (FNAC) because it shares many cytological features with other mimicking lesions. The aim of this study was to identify the cytological features that differentiate FNs from mimicking lesions...
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| Format: | Article |
| Language: | English |
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Korean Society of Pathologists & the Korean Society for Cytopathology
2018-03-01
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| Series: | Journal of Pathology and Translational Medicine |
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| Online Access: | http://www.jpatholtm.org/upload/pdf/jptm-2018-01-17.pdf |
| _version_ | 1818937241077022720 |
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| author | Kanghee Han Hwa-Jeong Ha Joon Seog Kong Jung-Soon Kim Jae Kyung Myung Jae Soo Koh Sunhoo Park Myung-Soon Shin Woo-Tack Song Hye Sil Seol Seung-Sook Lee |
| author_facet | Kanghee Han Hwa-Jeong Ha Joon Seog Kong Jung-Soon Kim Jae Kyung Myung Jae Soo Koh Sunhoo Park Myung-Soon Shin Woo-Tack Song Hye Sil Seol Seung-Sook Lee |
| author_sort | Kanghee Han |
| collection | DOAJ |
| description | Background It is difficult to correctly diagnose follicular neoplasms (FNs) on fine-needle aspiration cytology (FNAC) because it shares many cytological features with other mimicking lesions. The aim of this study was to identify the cytological features that differentiate FNs from mimicking lesions. Methods We included the cytological slides from 116 cases of thyroid FN diagnosed on FNAC, and included their subsequent histological diagnoses. We evaluated the cytological architectural pattern and nuclear features of the lesions according to their histological groups. Results The final histological diagnoses of the 116 cases varied, and included 51 FNs (44%), 47 papillary thyroid carcinomas (40%) including follicular variant, and seventeen cellular nodular hyperplasias (15%). Regardless of the final histological diagnosis, microfollicular pattern was observed in most cases. On the other hand, trabecular pattern was identified in 34% of FNs, but not in any other lesions. Additionally, elongated nuclei and ground glass chromatin were found in only some papillary thyroid carcinomas. Conclusions This study shows that the trabecular pattern is a representative cytological feature of FNs that can be used to distinguish FNs from mimicking lesions. In addition, nuclear shape and chromatin pattern can be used to further confirm the diagnosis of FNs from mimicking lesions through FNAC. |
| first_indexed | 2024-12-20T05:48:49Z |
| format | Article |
| id | doaj.art-79bcdde48d59419fa6d06646c28e38d4 |
| institution | Directory Open Access Journal |
| issn | 2383-7837 2383-7845 |
| language | English |
| last_indexed | 2024-12-20T05:48:49Z |
| publishDate | 2018-03-01 |
| publisher | Korean Society of Pathologists & the Korean Society for Cytopathology |
| record_format | Article |
| series | Journal of Pathology and Translational Medicine |
| spelling | doaj.art-79bcdde48d59419fa6d06646c28e38d42022-12-21T19:51:13ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452018-03-0152211012010.4132/jptm.2018.01.1716752Cytological Features That Differentiate Follicular Neoplasm from Mimicking LesionsKanghee Han0Hwa-Jeong Ha1Joon Seog Kong2Jung-Soon Kim3Jae Kyung Myung4Jae Soo Koh5Sunhoo Park6Myung-Soon Shin7Woo-Tack Song8Hye Sil Seol9Seung-Sook Lee10 Department of Pathology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, Korea Department of Pathology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, Korea Department of Pathology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, Korea Department of Pathology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, KoreaLaboratory of Radiation Pathology, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, Korea Department of Pathology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, KoreaLaboratory of Radiation Pathology, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, Korea Department of Pathology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, Korea Department of Pathology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, Korea Department of Pathology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, KoreaLaboratory of Radiation Pathology, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, KoreaBackground It is difficult to correctly diagnose follicular neoplasms (FNs) on fine-needle aspiration cytology (FNAC) because it shares many cytological features with other mimicking lesions. The aim of this study was to identify the cytological features that differentiate FNs from mimicking lesions. Methods We included the cytological slides from 116 cases of thyroid FN diagnosed on FNAC, and included their subsequent histological diagnoses. We evaluated the cytological architectural pattern and nuclear features of the lesions according to their histological groups. Results The final histological diagnoses of the 116 cases varied, and included 51 FNs (44%), 47 papillary thyroid carcinomas (40%) including follicular variant, and seventeen cellular nodular hyperplasias (15%). Regardless of the final histological diagnosis, microfollicular pattern was observed in most cases. On the other hand, trabecular pattern was identified in 34% of FNs, but not in any other lesions. Additionally, elongated nuclei and ground glass chromatin were found in only some papillary thyroid carcinomas. Conclusions This study shows that the trabecular pattern is a representative cytological feature of FNs that can be used to distinguish FNs from mimicking lesions. In addition, nuclear shape and chromatin pattern can be used to further confirm the diagnosis of FNs from mimicking lesions through FNAC.http://www.jpatholtm.org/upload/pdf/jptm-2018-01-17.pdfFollicular neoplasmFine needle aspiration cytologyDifferential diagnosis |
| spellingShingle | Kanghee Han Hwa-Jeong Ha Joon Seog Kong Jung-Soon Kim Jae Kyung Myung Jae Soo Koh Sunhoo Park Myung-Soon Shin Woo-Tack Song Hye Sil Seol Seung-Sook Lee Cytological Features That Differentiate Follicular Neoplasm from Mimicking Lesions Journal of Pathology and Translational Medicine Follicular neoplasm Fine needle aspiration cytology Differential diagnosis |
| title | Cytological Features That Differentiate Follicular Neoplasm from Mimicking Lesions |
| title_full | Cytological Features That Differentiate Follicular Neoplasm from Mimicking Lesions |
| title_fullStr | Cytological Features That Differentiate Follicular Neoplasm from Mimicking Lesions |
| title_full_unstemmed | Cytological Features That Differentiate Follicular Neoplasm from Mimicking Lesions |
| title_short | Cytological Features That Differentiate Follicular Neoplasm from Mimicking Lesions |
| title_sort | cytological features that differentiate follicular neoplasm from mimicking lesions |
| topic | Follicular neoplasm Fine needle aspiration cytology Differential diagnosis |
| url | http://www.jpatholtm.org/upload/pdf/jptm-2018-01-17.pdf |
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