Association of rs211037 GABRG2 gene polymorphism with susceptibility to idiopathic generalized epilepsy
Aim This case-control study aimed to determine a possible association of single nucleotide polymorphism rs211037 of the gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2) gene with the susceptibility to idiopathic generalized epilepsy (IGE) in the Macedonian population. Methods It enroll...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Medical Association of Zenica-Doboj Canton
2021-08-01
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| Series: | Medicinski Glasnik |
| Subjects: | |
| Online Access: | https://ljkzedo.ba/mgpdf/mg35/09_Milanovska_1367_A.pdf |
| Summary: | Aim This case-control study aimed to determine a possible
association of single nucleotide polymorphism rs211037 of the
gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2)
gene with the susceptibility to idiopathic generalized epilepsy
(IGE) in the Macedonian population.
Methods It enrolled 96 patients with clinically verified IGE and
51 healthy individuals without personal and family history of epilepsy or other neurological disorders as controls. A determination
of the GABRG2 rs211037 polymorphism was performed using the
TaqMan-based genotyping assay.
Results A significant dominant association of the CC genotype
(odds ratio - OR=2.100, 95% CI=1.018-4.332; p=0.043) and allelic association of C allele (OR=1.902, CI=1.040-3.477; p=0.035)
with susceptibility to IGE was found. Carriers of CC genotype
had approximately a 2-fold higher probability of developing IGE
than the carriers of CT and TT genotypes. Carriers of the C allele
had a 1.9-folds higher probability for IGE than the carriers of the
T allele.
Conclusion The polymorphism rs211037 of the GABRG2 gene
increases the risk of the development of idiopathic generalized
epilepsy in the Macedonian population. |
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| ISSN: | 1840-0132 1840-2445 |