Phosphorylation of the Human DNA Glycosylase NEIL2 Is Affected by Oxidative Stress and Modulates Its Activity

Phosphorylation of the Human DNA Glycosylase NEIL2 Is Affected by Oxidative Stress and Modulates Its Activity

The DNA glycosylase NEIL2 plays a central role in maintaining genome integrity, in particular during oxidative stress, by recognizing oxidized base lesions and initiating repair of these via the base excision repair (BER) pathway. Post-translational modifications are important molecular switches tha...

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Bibliographic Details
Main Authors: Camilla Myrup Holst, Nanna Brøndum Andersen, Vibeke Thinggaard, Mine Tilken, Sofie Lautrup, Cinzia Tesauro, Tinna Stevnsner
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Antioxidants
Subjects:
base excision repair
cyclin-dependent kinase 5
post-translational modifications
protein kinase C
Online Access:https://www.mdpi.com/2076-3921/12/2/355

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