Piperlongumine Analogs Promote A549 Cell Apoptosis through Enhancing ROS Generation

Piperlongumine Analogs Promote A549 Cell Apoptosis through Enhancing ROS Generation

Chemotherapeutic agents, which contain the Michael acceptor, are potent anticancer molecules by promoting intracellular reactive oxygen species (ROS) generation. In this study, we synthesized a panel of <b>PL</b> (piperlongumine) analogs with chlorine attaching at C2 and an electron-with...

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Bibliographic Details
Main Authors: Ai-Ling Sun, Wen-Wen Mu, Yan-Mo Li, Ya-Lei Sun, Peng-Xiao Li, Ren-Min Liu, Jie Yang, Guo-Yun Liu
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Molecules
Subjects:
piperlongumine an alog
michael acceptor
anticancer activity
reactive oxygen species
thioredoxin reductase
Online Access:https://www.mdpi.com/1420-3049/26/11/3243

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https://www.mdpi.com/1420-3049/26/11/3243

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