ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer
Although Krüppel-associated box zinc finger proteins (KZFPs) were found to mostly repress transposable elements, recent studies found that KFZPs also play other roles in cells. Here, the authors provide evidence that the KZFP ZFP30 promotes adipogenesis by targeting and activating a retrotransposon-...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09803-9 |
| _version_ | 1819035795385745408 |
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| author | Wanze Chen Petra C. Schwalie Eugenia V. Pankevich Carine Gubelmann Sunil K. Raghav Riccardo Dainese Marco Cassano Michael Imbeault Suk Min Jang Julie Russeil Tenagne Delessa Julien Duc Didier Trono Christian Wolfrum Bart Deplancke |
| author_facet | Wanze Chen Petra C. Schwalie Eugenia V. Pankevich Carine Gubelmann Sunil K. Raghav Riccardo Dainese Marco Cassano Michael Imbeault Suk Min Jang Julie Russeil Tenagne Delessa Julien Duc Didier Trono Christian Wolfrum Bart Deplancke |
| author_sort | Wanze Chen |
| collection | DOAJ |
| description | Although Krüppel-associated box zinc finger proteins (KZFPs) were found to mostly repress transposable elements, recent studies found that KFZPs also play other roles in cells. Here, the authors provide evidence that the KZFP ZFP30 promotes adipogenesis by targeting and activating a retrotransposon-derived Pparg2 enhancer in cooperation with co-regulator KRAB-associated protein 1 (KAP1). |
| first_indexed | 2024-12-21T07:55:18Z |
| format | Article |
| id | doaj.art-79c0840feab948d880b74c9fb3a62bf1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T07:55:18Z |
| publishDate | 2019-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-79c0840feab948d880b74c9fb3a62bf12022-12-21T19:11:00ZengNature PortfolioNature Communications2041-17232019-04-0110111610.1038/s41467-019-09803-9ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancerWanze Chen0Petra C. Schwalie1Eugenia V. Pankevich2Carine Gubelmann3Sunil K. Raghav4Riccardo Dainese5Marco Cassano6Michael Imbeault7Suk Min Jang8Julie Russeil9Tenagne Delessa10Julien Duc11Didier Trono12Christian Wolfrum13Bart Deplancke14Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL)Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL)Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL)Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL)Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL)Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL)Laboratory of Virology and Genetics, Global Health Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL)Laboratory of Virology and Genetics, Global Health Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL)Laboratory of Virology and Genetics, Global Health Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL)Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL)Institute of Food Nutrition and Health, Eidgenössische Technische Hochschule Zürich (ETHZ)Laboratory of Virology and Genetics, Global Health Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL)Laboratory of Virology and Genetics, Global Health Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL)Institute of Food Nutrition and Health, Eidgenössische Technische Hochschule Zürich (ETHZ)Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL)Although Krüppel-associated box zinc finger proteins (KZFPs) were found to mostly repress transposable elements, recent studies found that KFZPs also play other roles in cells. Here, the authors provide evidence that the KZFP ZFP30 promotes adipogenesis by targeting and activating a retrotransposon-derived Pparg2 enhancer in cooperation with co-regulator KRAB-associated protein 1 (KAP1).https://doi.org/10.1038/s41467-019-09803-9 |
| spellingShingle | Wanze Chen Petra C. Schwalie Eugenia V. Pankevich Carine Gubelmann Sunil K. Raghav Riccardo Dainese Marco Cassano Michael Imbeault Suk Min Jang Julie Russeil Tenagne Delessa Julien Duc Didier Trono Christian Wolfrum Bart Deplancke ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer Nature Communications |
| title | ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer |
| title_full | ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer |
| title_fullStr | ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer |
| title_full_unstemmed | ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer |
| title_short | ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer |
| title_sort | zfp30 promotes adipogenesis through the kap1 mediated activation of a retrotransposon derived pparg2 enhancer |
| url | https://doi.org/10.1038/s41467-019-09803-9 |
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