Age-related variations in corneal biomechanical properties
Purpose: To determine age-related changes in corneal viscoelastic properties in healthy individuals. Methods: This observational cross-sectional study was performed at the Department of Ophthalmology, Imam Khomeini Hospital, Ahvaz, Iran and included 302 healthy individuals in 6 age decades (range: 1...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-09-01
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| Series: | Journal of Current Ophthalmology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S245223251630021X |
| _version_ | 1818608039683424256 |
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| author | Farideh Sharifipour Mahmoodreza Panahi-bazaz Roghayeh Bidar Aida Idani Bahman Cheraghian |
| author_facet | Farideh Sharifipour Mahmoodreza Panahi-bazaz Roghayeh Bidar Aida Idani Bahman Cheraghian |
| author_sort | Farideh Sharifipour |
| collection | DOAJ |
| description | Purpose: To determine age-related changes in corneal viscoelastic properties in healthy individuals.
Methods: This observational cross-sectional study was performed at the Department of Ophthalmology, Imam Khomeini Hospital, Ahvaz, Iran and included 302 healthy individuals in 6 age decades (range: 10–69 years). After complete ocular examination, corneal viscoelastic properties were measured by ocular response analyzer and central corneal thickness (CCT) by an ultrasonic pachymeter. Our main outcome measures were corneal viscoelastic properties in different age groups.
Results: Corneal hysteresis (CH) and corneal resistance factor (CRF) showed a significant negative correlation with age (P < 0.001 for both, r = −0.353 and r = −0.246, respectively). Female gender had significantly higher CH (P = 0.017) and CRF (P = 0.019). CH and CRF were significantly correlated (P < 0.001, r = 0.821). CCT showed a biphasic pattern with significantly higher thicknesses before 20 and after 50 years of age. CH and CRF were significantly correlated with CCT (P < 0.001 for both, r = 0.21 and r = 0.26, respectively) and intraocular pressure (IOP) (P < 0.001 for both, r = −0.474 and r = 0.598, respectively). Corneal-compensated IOP (IOPcc) was significantly higher after age 40 compared to age group <20 (p < 0.045). Goldmann-correlated IOP (IOPg) was significantly correlated with CCT (P = 0.001, r = 0.193), while IOPcc showed no correlation with CCT (P = 0.265, r = 0.062). CH was significantly higher in hyperopic eyes compared to emmetropic eyes (P = 0.009) and myopic eye (P < 0.001).
Conclusions: In this study, there was a decrease in CH and CRF with an increase in age. Hyperopia and female gender are associated with higher CH and CRF. CCT is higher toward the extremes of life and is significantly correlated with CH and CRF. |
| first_indexed | 2024-12-16T14:36:19Z |
| format | Article |
| id | doaj.art-79c21840f1864621baed92a5cfe87062 |
| institution | Directory Open Access Journal |
| issn | 2452-2325 |
| language | English |
| last_indexed | 2024-12-16T14:36:19Z |
| publishDate | 2016-09-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Current Ophthalmology |
| spelling | doaj.art-79c21840f1864621baed92a5cfe870622022-12-21T22:28:06ZengWolters Kluwer Medknow PublicationsJournal of Current Ophthalmology2452-23252016-09-0128311712210.1016/j.joco.2016.05.004Age-related variations in corneal biomechanical propertiesFarideh Sharifipour0Mahmoodreza Panahi-bazaz1Roghayeh Bidar2Aida Idani3Bahman Cheraghian4Department of Ophthalmology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Ophthalmology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Ophthalmology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranIran University of Medical Sciences, Tehran, IranDepartment of Biostatics and Epidemiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranPurpose: To determine age-related changes in corneal viscoelastic properties in healthy individuals. Methods: This observational cross-sectional study was performed at the Department of Ophthalmology, Imam Khomeini Hospital, Ahvaz, Iran and included 302 healthy individuals in 6 age decades (range: 10–69 years). After complete ocular examination, corneal viscoelastic properties were measured by ocular response analyzer and central corneal thickness (CCT) by an ultrasonic pachymeter. Our main outcome measures were corneal viscoelastic properties in different age groups. Results: Corneal hysteresis (CH) and corneal resistance factor (CRF) showed a significant negative correlation with age (P < 0.001 for both, r = −0.353 and r = −0.246, respectively). Female gender had significantly higher CH (P = 0.017) and CRF (P = 0.019). CH and CRF were significantly correlated (P < 0.001, r = 0.821). CCT showed a biphasic pattern with significantly higher thicknesses before 20 and after 50 years of age. CH and CRF were significantly correlated with CCT (P < 0.001 for both, r = 0.21 and r = 0.26, respectively) and intraocular pressure (IOP) (P < 0.001 for both, r = −0.474 and r = 0.598, respectively). Corneal-compensated IOP (IOPcc) was significantly higher after age 40 compared to age group <20 (p < 0.045). Goldmann-correlated IOP (IOPg) was significantly correlated with CCT (P = 0.001, r = 0.193), while IOPcc showed no correlation with CCT (P = 0.265, r = 0.062). CH was significantly higher in hyperopic eyes compared to emmetropic eyes (P = 0.009) and myopic eye (P < 0.001). Conclusions: In this study, there was a decrease in CH and CRF with an increase in age. Hyperopia and female gender are associated with higher CH and CRF. CCT is higher toward the extremes of life and is significantly correlated with CH and CRF.http://www.sciencedirect.com/science/article/pii/S245223251630021XCorneal hysteresisCorneal resistance factorOcular response analyzerAging |
| spellingShingle | Farideh Sharifipour Mahmoodreza Panahi-bazaz Roghayeh Bidar Aida Idani Bahman Cheraghian Age-related variations in corneal biomechanical properties Journal of Current Ophthalmology Corneal hysteresis Corneal resistance factor Ocular response analyzer Aging |
| title | Age-related variations in corneal biomechanical properties |
| title_full | Age-related variations in corneal biomechanical properties |
| title_fullStr | Age-related variations in corneal biomechanical properties |
| title_full_unstemmed | Age-related variations in corneal biomechanical properties |
| title_short | Age-related variations in corneal biomechanical properties |
| title_sort | age related variations in corneal biomechanical properties |
| topic | Corneal hysteresis Corneal resistance factor Ocular response analyzer Aging |
| url | http://www.sciencedirect.com/science/article/pii/S245223251630021X |
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