Fulminant inflammatory demyelination presenting as stroke‐in‐evolution in an elderly subject
Abstract Background Fulminant inflammatory demyelination is a possible presentation of inflammatory demyelinating disorders, thus representing a potential stroke mimic especially in younger patients. Aims of the study To describe clinical and diagnostic pitfalls in a case of fulminant inflammatory d...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-08-01
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| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.1967 |
| _version_ | 1797754659757096960 |
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| author | Simone Sacco Ilaria Callegari Isabella Canavero Elisa Coloberti Lisa Maria Farina Sabrina Ravaglia Anna Simoncelli Anna Pichiecchio Giuseppe Micieli |
| author_facet | Simone Sacco Ilaria Callegari Isabella Canavero Elisa Coloberti Lisa Maria Farina Sabrina Ravaglia Anna Simoncelli Anna Pichiecchio Giuseppe Micieli |
| author_sort | Simone Sacco |
| collection | DOAJ |
| description | Abstract Background Fulminant inflammatory demyelination is a possible presentation of inflammatory demyelinating disorders, thus representing a potential stroke mimic especially in younger patients. Aims of the study To describe clinical and diagnostic pitfalls in a case of fulminant inflammatory demyelination presenting with stroke‐like symptoms in an elderly patient. Methods Case report and case‐based review of the literature. Results A 67‐year‐old woman, who accessed the emergency room as suspect stroke for hyperacute onset of rapidly worsening speech impairment and drowsiness, was later diagnosed with a huge brain inflammatory demyelination. Clinical, laboratory, and neuroimaging tests did not allow to put a more specific diagnosis. Due to the rapidly deteriorating course, she received immunosuppression with benefit. Conclusion This report is meant to highlight the diagnostic challenges connected with fulminant inflammatory demyelination, which sometime can resemble a stroke‐in evolution and appear clinically unfitting for inclusion in any specific pathological entities within the broad‐spectrum of inflammatory demyelinating disorders. |
| first_indexed | 2024-03-12T17:35:36Z |
| format | Article |
| id | doaj.art-79c34ff72ddd4426957ac5414b7969a8 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-12T17:35:36Z |
| publishDate | 2021-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-79c34ff72ddd4426957ac5414b7969a82023-08-04T10:56:25ZengWileyBrain and Behavior2162-32792021-08-01118n/an/a10.1002/brb3.1967Fulminant inflammatory demyelination presenting as stroke‐in‐evolution in an elderly subjectSimone Sacco0Ilaria Callegari1Isabella Canavero2Elisa Coloberti3Lisa Maria Farina4Sabrina Ravaglia5Anna Simoncelli6Anna Pichiecchio7Giuseppe Micieli8Department of Clinical Surgical Diagnostic and Pediatric Sciences Institute of Radiology University of Pavia Pavia ItalyNeuroscience Consortium Monza Policlinico and Pavia Mondino University of Pavia Pavia ItalyEmergency Neurology Unit IRCCS Mondino Foundation Pavia ItalyEmergency Neurology Unit IRCCS Mondino Foundation Pavia ItalyNeuroradiology Unit IRCCS Mondino Foundation Pavia ItalyEmergency Neurology Unit IRCCS Mondino Foundation Pavia ItalyDiagnostic Radiology Interventional Radiology and Neuroradiology Unit Fondazione IRCCS Policlinico San Matteo Pavia ItalyNeuroradiology Unit IRCCS Mondino Foundation Pavia ItalyEmergency Neurology Unit IRCCS Mondino Foundation Pavia ItalyAbstract Background Fulminant inflammatory demyelination is a possible presentation of inflammatory demyelinating disorders, thus representing a potential stroke mimic especially in younger patients. Aims of the study To describe clinical and diagnostic pitfalls in a case of fulminant inflammatory demyelination presenting with stroke‐like symptoms in an elderly patient. Methods Case report and case‐based review of the literature. Results A 67‐year‐old woman, who accessed the emergency room as suspect stroke for hyperacute onset of rapidly worsening speech impairment and drowsiness, was later diagnosed with a huge brain inflammatory demyelination. Clinical, laboratory, and neuroimaging tests did not allow to put a more specific diagnosis. Due to the rapidly deteriorating course, she received immunosuppression with benefit. Conclusion This report is meant to highlight the diagnostic challenges connected with fulminant inflammatory demyelination, which sometime can resemble a stroke‐in evolution and appear clinically unfitting for inclusion in any specific pathological entities within the broad‐spectrum of inflammatory demyelinating disorders.https://doi.org/10.1002/brb3.1967ADEMfulminant inflammatory demyelinationinflammatory demyelinating disorderstumefactive demyelinating lesions |
| spellingShingle | Simone Sacco Ilaria Callegari Isabella Canavero Elisa Coloberti Lisa Maria Farina Sabrina Ravaglia Anna Simoncelli Anna Pichiecchio Giuseppe Micieli Fulminant inflammatory demyelination presenting as stroke‐in‐evolution in an elderly subject Brain and Behavior ADEM fulminant inflammatory demyelination inflammatory demyelinating disorders tumefactive demyelinating lesions |
| title | Fulminant inflammatory demyelination presenting as stroke‐in‐evolution in an elderly subject |
| title_full | Fulminant inflammatory demyelination presenting as stroke‐in‐evolution in an elderly subject |
| title_fullStr | Fulminant inflammatory demyelination presenting as stroke‐in‐evolution in an elderly subject |
| title_full_unstemmed | Fulminant inflammatory demyelination presenting as stroke‐in‐evolution in an elderly subject |
| title_short | Fulminant inflammatory demyelination presenting as stroke‐in‐evolution in an elderly subject |
| title_sort | fulminant inflammatory demyelination presenting as stroke in evolution in an elderly subject |
| topic | ADEM fulminant inflammatory demyelination inflammatory demyelinating disorders tumefactive demyelinating lesions |
| url | https://doi.org/10.1002/brb3.1967 |
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