Stereoselective Synthesis of Southern Fragment of Hantupeptin-A
The stereo selective synthesis of the southern fragment (C21-C41) of Hantupeptin–A is described. The required stereochemistry of b-hydroxy-a-methyl acid unit was accomplished through Aldol reaction using Evan’s chiral auxiliary followed by the installation of terminal alkyne with Ohira–Bestmann reag...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Slovenian Chemical Society
2016-05-01
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| Series: | Acta Chimica Slovenica |
| Subjects: | |
| Online Access: | https://journals.matheo.si/index.php/ACSi/article/view/2322 |
| _version_ | 1819049784697159680 |
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| author | Sri Nivas Avula Malladi Sunitha Rao Govind Chakunta |
| author_facet | Sri Nivas Avula Malladi Sunitha Rao Govind Chakunta |
| author_sort | Sri Nivas Avula |
| collection | DOAJ |
| description | The stereo selective synthesis of the southern fragment (C21-C41) of Hantupeptin–A is described. The required stereochemistry of b-hydroxy-a-methyl acid unit was accomplished through Aldol reaction using Evan’s chiral auxiliary followed by the installation of terminal alkyne with Ohira–Bestmann reagent. |
| first_indexed | 2024-12-21T11:37:39Z |
| format | Article |
| id | doaj.art-79c44422da854d33a8dc279b05a96603 |
| institution | Directory Open Access Journal |
| issn | 1318-0207 1580-3155 |
| language | English |
| last_indexed | 2024-12-21T11:37:39Z |
| publishDate | 2016-05-01 |
| publisher | Slovenian Chemical Society |
| record_format | Article |
| series | Acta Chimica Slovenica |
| spelling | doaj.art-79c44422da854d33a8dc279b05a966032022-12-21T19:05:24ZengSlovenian Chemical SocietyActa Chimica Slovenica1318-02071580-31552016-05-0163234435010.17344/acsi.2016.2322351Stereoselective Synthesis of Southern Fragment of Hantupeptin-ASri Nivas Avula0Malladi SunithaRao Govind ChakuntaLec in chemistryThe stereo selective synthesis of the southern fragment (C21-C41) of Hantupeptin–A is described. The required stereochemistry of b-hydroxy-a-methyl acid unit was accomplished through Aldol reaction using Evan’s chiral auxiliary followed by the installation of terminal alkyne with Ohira–Bestmann reagent.https://journals.matheo.si/index.php/ACSi/article/view/2322Hantupeptin AAldol ReactionStereoselective synthesisPeptideEvan’s auxiliary |
| spellingShingle | Sri Nivas Avula Malladi Sunitha Rao Govind Chakunta Stereoselective Synthesis of Southern Fragment of Hantupeptin-A Acta Chimica Slovenica Hantupeptin A Aldol Reaction Stereoselective synthesis Peptide Evan’s auxiliary |
| title | Stereoselective Synthesis of Southern Fragment of Hantupeptin-A |
| title_full | Stereoselective Synthesis of Southern Fragment of Hantupeptin-A |
| title_fullStr | Stereoselective Synthesis of Southern Fragment of Hantupeptin-A |
| title_full_unstemmed | Stereoselective Synthesis of Southern Fragment of Hantupeptin-A |
| title_short | Stereoselective Synthesis of Southern Fragment of Hantupeptin-A |
| title_sort | stereoselective synthesis of southern fragment of hantupeptin a |
| topic | Hantupeptin A Aldol Reaction Stereoselective synthesis Peptide Evan’s auxiliary |
| url | https://journals.matheo.si/index.php/ACSi/article/view/2322 |
| work_keys_str_mv | AT srinivasavula stereoselectivesynthesisofsouthernfragmentofhantupeptina AT malladisunitha stereoselectivesynthesisofsouthernfragmentofhantupeptina AT raogovindchakunta stereoselectivesynthesisofsouthernfragmentofhantupeptina |