The Emerging Role of Cell Adhesion Molecules on Benign Prostatic Hyperplasia
Benign prostatic hyperplasia (BPH) is a common disease in elderly men. It is characterized by prostatic enlargement and urethral compression and often causes lower urinary tract symptoms (LUTs) such as urinary frequency, urgency, and nocturia. Existing studies have shown that the pathological proces...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/3/2870 |
| _version_ | 1797624228342661120 |
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| author | Jiang Liu Junchao Zhang Xun Fu Shu Yang Yan Li Jianmin Liu Michael E. DiSanto Ping Chen Xinhua Zhang |
| author_facet | Jiang Liu Junchao Zhang Xun Fu Shu Yang Yan Li Jianmin Liu Michael E. DiSanto Ping Chen Xinhua Zhang |
| author_sort | Jiang Liu |
| collection | DOAJ |
| description | Benign prostatic hyperplasia (BPH) is a common disease in elderly men. It is characterized by prostatic enlargement and urethral compression and often causes lower urinary tract symptoms (LUTs) such as urinary frequency, urgency, and nocturia. Existing studies have shown that the pathological process of prostate hyperplasia is mainly related to the imbalance of cell proliferation and apoptosis, inflammation, epithelial–mesenchymal transition (EMT), and growth factors. However, the exact molecular mechanisms remain incompletely elucidated. Cell adhesion molecules (CAMs) are a group of cell surface proteins that mediate cell–cell adhesion and cell migration. Modulating adhesion molecule expression can regulate cell proliferation, apoptosis, EMT, and fibrotic processes, engaged in the development of prostatic hyperplasia. In this review, we went over the important roles and molecular mechanisms of cell adhesion molecules (mainly integrins and cadherins) in both physiological and pathological processes. We also analyzed the mechanisms of CAMs in prostate hyperplasia and explored the potential value of targeting CAMs as a therapeutic strategy for BPH. |
| first_indexed | 2024-03-11T09:39:59Z |
| format | Article |
| id | doaj.art-79c63dcc201b4cb0b633c4b209ee46d4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:39:59Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-79c63dcc201b4cb0b633c4b209ee46d42023-11-16T17:03:35ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01243287010.3390/ijms24032870The Emerging Role of Cell Adhesion Molecules on Benign Prostatic HyperplasiaJiang Liu0Junchao Zhang1Xun Fu2Shu Yang3Yan Li4Jianmin Liu5Michael E. DiSanto6Ping Chen7Xinhua Zhang8Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, ChinaDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, ChinaDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, ChinaDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, ChinaDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, ChinaDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, ChinaDepartment of Surgery and Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ 08103, USADepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, ChinaDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, ChinaBenign prostatic hyperplasia (BPH) is a common disease in elderly men. It is characterized by prostatic enlargement and urethral compression and often causes lower urinary tract symptoms (LUTs) such as urinary frequency, urgency, and nocturia. Existing studies have shown that the pathological process of prostate hyperplasia is mainly related to the imbalance of cell proliferation and apoptosis, inflammation, epithelial–mesenchymal transition (EMT), and growth factors. However, the exact molecular mechanisms remain incompletely elucidated. Cell adhesion molecules (CAMs) are a group of cell surface proteins that mediate cell–cell adhesion and cell migration. Modulating adhesion molecule expression can regulate cell proliferation, apoptosis, EMT, and fibrotic processes, engaged in the development of prostatic hyperplasia. In this review, we went over the important roles and molecular mechanisms of cell adhesion molecules (mainly integrins and cadherins) in both physiological and pathological processes. We also analyzed the mechanisms of CAMs in prostate hyperplasia and explored the potential value of targeting CAMs as a therapeutic strategy for BPH.https://www.mdpi.com/1422-0067/24/3/2870cell adhesion moleculesbenign prostatic hyperplasiacadherinsintegrins |
| spellingShingle | Jiang Liu Junchao Zhang Xun Fu Shu Yang Yan Li Jianmin Liu Michael E. DiSanto Ping Chen Xinhua Zhang The Emerging Role of Cell Adhesion Molecules on Benign Prostatic Hyperplasia International Journal of Molecular Sciences cell adhesion molecules benign prostatic hyperplasia cadherins integrins |
| title | The Emerging Role of Cell Adhesion Molecules on Benign Prostatic Hyperplasia |
| title_full | The Emerging Role of Cell Adhesion Molecules on Benign Prostatic Hyperplasia |
| title_fullStr | The Emerging Role of Cell Adhesion Molecules on Benign Prostatic Hyperplasia |
| title_full_unstemmed | The Emerging Role of Cell Adhesion Molecules on Benign Prostatic Hyperplasia |
| title_short | The Emerging Role of Cell Adhesion Molecules on Benign Prostatic Hyperplasia |
| title_sort | emerging role of cell adhesion molecules on benign prostatic hyperplasia |
| topic | cell adhesion molecules benign prostatic hyperplasia cadherins integrins |
| url | https://www.mdpi.com/1422-0067/24/3/2870 |
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