In-Clinic Measurements of Vascular Risk and Brain Activity
Background: Cardiovascular disease and dementia represent two health problems that may be causally connected. Studies have shown patients with dementia to have reduced cardiovascular health measures, where patients with dementia also have reduced electrophysiological brain activity as measured by ev...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Journal of Ageing and Longevity |
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| Online Access: | https://www.mdpi.com/2673-9259/2/3/20 |
| _version_ | 1797464971363221504 |
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| author | Jeffrey Boone Anna H. Davids David Joffe Francesca Arese Lucini David S. Oakley Madeleine J. Oakley Matthew Peterson |
| author_facet | Jeffrey Boone Anna H. Davids David Joffe Francesca Arese Lucini David S. Oakley Madeleine J. Oakley Matthew Peterson |
| author_sort | Jeffrey Boone |
| collection | DOAJ |
| description | Background: Cardiovascular disease and dementia represent two health problems that may be causally connected. Studies have shown patients with dementia to have reduced cardiovascular health measures, where patients with dementia also have reduced electrophysiological brain activity as measured by event-related potentials (ERP’s). Few studies have attempted to correlate the two: cardiovascular health and ERP brain activity. The objective of this study is to determine if there are ERP differences between patients with lower versus higher measures of cardiovascular risk. Methods: For 180 patients ages 53 (16) years, Audio P300 ERP amplitudes and latencies (speeds) were measured upon initial patient visit alongside other clinical evaluations. Cardiovascular risk was categorized into good versus poor levels for blood pressure resting and stressed, E/A Ratio, atherosclerosis, and carotid intima-media thickness. Results: Groups with good levels had lower latencies (faster P300′s) and higher amplitudes than those with poor levels across all cardiovascular risk measures, significant to <i>p</i> < 0.05 for most parameters. While both cardiovascular health and P300 metrics decline with age, poor blood pressure and plaque was seen to affect P300 performance across all age groups in this study. Conclusion: These data suggest correlation between brain activity, as measured by the P300, and five standard measures of cardiovascular health and this correlation may begin at an early age. While further explorations are warranted, these results could have implications on the management of preventative medicine by bringing preventative cardiology and brain health together. |
| first_indexed | 2024-03-09T18:15:47Z |
| format | Article |
| id | doaj.art-79c73ad1fd7a48ff9900437af9674eab |
| institution | Directory Open Access Journal |
| issn | 2673-9259 |
| language | English |
| last_indexed | 2024-03-09T18:15:47Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Ageing and Longevity |
| spelling | doaj.art-79c73ad1fd7a48ff9900437af9674eab2023-11-24T08:46:41ZengMDPI AGJournal of Ageing and Longevity2673-92592022-08-012324025110.3390/jal2030020In-Clinic Measurements of Vascular Risk and Brain ActivityJeffrey Boone0Anna H. Davids1David Joffe2Francesca Arese Lucini3David S. Oakley4Madeleine J. Oakley5Matthew Peterson6School of Medicine, University of Colorado, Denver, CO 80045, USAEastern Virginia Medical School, Norfolk, VA 23507, USAWAVi Research, Boulder, CO 80101, USAWAVi Research, Boulder, CO 80101, USAWAVi Research, Boulder, CO 80101, USADepartment of Linguistics, Georgetown University, Washington, DC 20057, USABaylor College of Medicine, Houston, TX 77030, USABackground: Cardiovascular disease and dementia represent two health problems that may be causally connected. Studies have shown patients with dementia to have reduced cardiovascular health measures, where patients with dementia also have reduced electrophysiological brain activity as measured by event-related potentials (ERP’s). Few studies have attempted to correlate the two: cardiovascular health and ERP brain activity. The objective of this study is to determine if there are ERP differences between patients with lower versus higher measures of cardiovascular risk. Methods: For 180 patients ages 53 (16) years, Audio P300 ERP amplitudes and latencies (speeds) were measured upon initial patient visit alongside other clinical evaluations. Cardiovascular risk was categorized into good versus poor levels for blood pressure resting and stressed, E/A Ratio, atherosclerosis, and carotid intima-media thickness. Results: Groups with good levels had lower latencies (faster P300′s) and higher amplitudes than those with poor levels across all cardiovascular risk measures, significant to <i>p</i> < 0.05 for most parameters. While both cardiovascular health and P300 metrics decline with age, poor blood pressure and plaque was seen to affect P300 performance across all age groups in this study. Conclusion: These data suggest correlation between brain activity, as measured by the P300, and five standard measures of cardiovascular health and this correlation may begin at an early age. While further explorations are warranted, these results could have implications on the management of preventative medicine by bringing preventative cardiology and brain health together.https://www.mdpi.com/2673-9259/2/3/20electroencephalogram (EEG)P300event related potential (ERP)brainwavecardiovascular disease (CVD) |
| spellingShingle | Jeffrey Boone Anna H. Davids David Joffe Francesca Arese Lucini David S. Oakley Madeleine J. Oakley Matthew Peterson In-Clinic Measurements of Vascular Risk and Brain Activity Journal of Ageing and Longevity electroencephalogram (EEG) P300 event related potential (ERP) brainwave cardiovascular disease (CVD) |
| title | In-Clinic Measurements of Vascular Risk and Brain Activity |
| title_full | In-Clinic Measurements of Vascular Risk and Brain Activity |
| title_fullStr | In-Clinic Measurements of Vascular Risk and Brain Activity |
| title_full_unstemmed | In-Clinic Measurements of Vascular Risk and Brain Activity |
| title_short | In-Clinic Measurements of Vascular Risk and Brain Activity |
| title_sort | in clinic measurements of vascular risk and brain activity |
| topic | electroencephalogram (EEG) P300 event related potential (ERP) brainwave cardiovascular disease (CVD) |
| url | https://www.mdpi.com/2673-9259/2/3/20 |
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