Rules for body fat interventions based on an operating point mechanism
Summary: Interventions to reduce fat are important for human health. However, they can have opposing effects such as exercise that decreases fat but increases food intake, or coherent effects such as leptin resistance which raises both. Furthermore, some interventions show an overshoot in food intak...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-02-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223001244 |
| _version_ | 1797903318902636544 |
|---|---|
| author | Alon Bar Omer Karin Avi Mayo Danny Ben-Zvi Uri Alon |
| author_facet | Alon Bar Omer Karin Avi Mayo Danny Ben-Zvi Uri Alon |
| author_sort | Alon Bar |
| collection | DOAJ |
| description | Summary: Interventions to reduce fat are important for human health. However, they can have opposing effects such as exercise that decreases fat but increases food intake, or coherent effects such as leptin resistance which raises both. Furthermore, some interventions show an overshoot in food intake, such as recovery from a diet, whereas others do not. To explain these properties we present a graphical framework called the operating point model, based on leptin control of feeding behavior. Steady-state fat and food intake is given by the intersection of two experimental curves – steady-state fat at a given food intake and ad libitum food intake at a given fat level. Depending on which curve an intervention shifts, it has opposing or coherent effects with or without overshoot, in excellent agreement with rodent data. The model also explains the quadratic relation between leptin and fat in humans. These concepts may guide the understanding of fat regulation disorders. |
| first_indexed | 2024-04-10T09:30:59Z |
| format | Article |
| id | doaj.art-79ca39af93ee4a759a1d2bd8ccf39f66 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-10T09:30:59Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-79ca39af93ee4a759a1d2bd8ccf39f662023-02-19T04:27:04ZengElsevieriScience2589-00422023-02-01262106047Rules for body fat interventions based on an operating point mechanismAlon Bar0Omer Karin1Avi Mayo2Danny Ben-Zvi3Uri Alon4Department Molecular Cell Biology, Weizmann Institute, Rehovot, IsraelDepartment Molecular Cell Biology, Weizmann Institute, Rehovot, Israel; Department of Mathematics, Imperial College London, London, SW7 2AZ, UKDepartment Molecular Cell Biology, Weizmann Institute, Rehovot, IsraelDepartment of Developmental Biology and Cancer Research, Institute for Medical Research Israel Canada, Hebrew University-Hadassah Medical School, Jerusalem, IsraelDepartment Molecular Cell Biology, Weizmann Institute, Rehovot, Israel; Corresponding authorSummary: Interventions to reduce fat are important for human health. However, they can have opposing effects such as exercise that decreases fat but increases food intake, or coherent effects such as leptin resistance which raises both. Furthermore, some interventions show an overshoot in food intake, such as recovery from a diet, whereas others do not. To explain these properties we present a graphical framework called the operating point model, based on leptin control of feeding behavior. Steady-state fat and food intake is given by the intersection of two experimental curves – steady-state fat at a given food intake and ad libitum food intake at a given fat level. Depending on which curve an intervention shifts, it has opposing or coherent effects with or without overshoot, in excellent agreement with rodent data. The model also explains the quadratic relation between leptin and fat in humans. These concepts may guide the understanding of fat regulation disorders.http://www.sciencedirect.com/science/article/pii/S2589004223001244Biological sciencesPhysiologyHuman metabolismEndocrinologyMathematical biosciences |
| spellingShingle | Alon Bar Omer Karin Avi Mayo Danny Ben-Zvi Uri Alon Rules for body fat interventions based on an operating point mechanism iScience Biological sciences Physiology Human metabolism Endocrinology Mathematical biosciences |
| title | Rules for body fat interventions based on an operating point mechanism |
| title_full | Rules for body fat interventions based on an operating point mechanism |
| title_fullStr | Rules for body fat interventions based on an operating point mechanism |
| title_full_unstemmed | Rules for body fat interventions based on an operating point mechanism |
| title_short | Rules for body fat interventions based on an operating point mechanism |
| title_sort | rules for body fat interventions based on an operating point mechanism |
| topic | Biological sciences Physiology Human metabolism Endocrinology Mathematical biosciences |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223001244 |
| work_keys_str_mv | AT alonbar rulesforbodyfatinterventionsbasedonanoperatingpointmechanism AT omerkarin rulesforbodyfatinterventionsbasedonanoperatingpointmechanism AT avimayo rulesforbodyfatinterventionsbasedonanoperatingpointmechanism AT dannybenzvi rulesforbodyfatinterventionsbasedonanoperatingpointmechanism AT urialon rulesforbodyfatinterventionsbasedonanoperatingpointmechanism |