Discovery of a novel hybrid coumarin-hydroxamate conjugate targeting the HDAC1-Sp1-FOSL2 signaling axis for breast cancer therapy

Discovery of a novel hybrid coumarin-hydroxamate conjugate targeting the HDAC1-Sp1-FOSL2 signaling axis for breast cancer therapy

Abstract Background Breast cancer is one of the most lethal cancers in women. Despite significant advances in the diagnosis and treatment of breast cancer, many patients still succumb to this disease, and thus, novel effective treatments are urgently needed. Natural product coumarin has been broadly...

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Hlavní autoři: Sujie Zhu, Wenjing Zhu, Kaihua Zhao, Jie Yu, Wenxia Lu, Rui Zhou, Shule Fan, Weikaixin Kong, Feifei Yang, Peipei Shan
Médium: Článek
Jazyk:English
Vydáno: BMC 2024-07-01
Edice:Cell Communication and Signaling
Témata:
Breast cancer
Metastasis
Tumor growth
Histone deacetylases inhibitor
Coumarins
FOSL2
On-line přístup:https://doi.org/10.1186/s12964-024-01733-4

Internet

https://doi.org/10.1186/s12964-024-01733-4

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