Discovery of a novel hybrid coumarin-hydroxamate conjugate targeting the HDAC1-Sp1-FOSL2 signaling axis for breast cancer therapy
Abstract Background Breast cancer is one of the most lethal cancers in women. Despite significant advances in the diagnosis and treatment of breast cancer, many patients still succumb to this disease, and thus, novel effective treatments are urgently needed. Natural product coumarin has been broadly...
Hlavní autoři: | Sujie Zhu, Wenjing Zhu, Kaihua Zhao, Jie Yu, Wenxia Lu, Rui Zhou, Shule Fan, Weikaixin Kong, Feifei Yang, Peipei Shan |
---|---|
Médium: | Článek |
Jazyk: | English |
Vydáno: |
BMC
2024-07-01
|
Edice: | Cell Communication and Signaling |
Témata: | |
On-line přístup: | https://doi.org/10.1186/s12964-024-01733-4 |
Podobné jednotky
-
The Role of HDACs as Leukemia Therapy Targets using HDI
Autor: Ahmad Ahmadzadeh, a další
Vydáno: (2016-02-01) -
KLF14 inhibits tumor progression via FOSL1 in glioma
Autor: Xiaohua Wang, a další
Vydáno: (2025-03-01) -
Design, Synthesis and Biological Evaluation of Novel Coumarin-Based Hydroxamate Derivatives as Histone Deacetylase (Hdac) Inhibitors with Antitumor Activities
Autor: Feifei Yang, a další
Vydáno: (2019-07-01) -
Influence of FOSL1 Inhibition on Vascular Calcification and ROS Generation through Ferroptosis via P53-SLC7A11 Axis
Autor: Sisi Shao, a další
Vydáno: (2023-02-01) -
Small Molecules Targeting HATs, HDACs, and BRDs in Cancer Therapy
Autor: Donglu Wu, a další
Vydáno: (2020-11-01)