Discovery of a novel hybrid coumarin-hydroxamate conjugate targeting the HDAC1-Sp1-FOSL2 signaling axis for breast cancer therapy

Discovery of a novel hybrid coumarin-hydroxamate conjugate targeting the HDAC1-Sp1-FOSL2 signaling axis for breast cancer therapy

Abstract Background Breast cancer is one of the most lethal cancers in women. Despite significant advances in the diagnosis and treatment of breast cancer, many patients still succumb to this disease, and thus, novel effective treatments are urgently needed. Natural product coumarin has been broadly...

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Detaylı Bibliyografya
Asıl Yazarlar: Sujie Zhu, Wenjing Zhu, Kaihua Zhao, Jie Yu, Wenxia Lu, Rui Zhou, Shule Fan, Weikaixin Kong, Feifei Yang, Peipei Shan
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: BMC 2024-07-01
Seri Bilgileri:Cell Communication and Signaling
Konular:
Breast cancer
Metastasis
Tumor growth
Histone deacetylases inhibitor
Coumarins
FOSL2
Online Erişim:https://doi.org/10.1186/s12964-024-01733-4

Internet

https://doi.org/10.1186/s12964-024-01733-4

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