The utility of PET imaging in depression
This educational review article aims to discuss growing evidence from PET studies in the diagnosis and treatment of depression. PET has been used in depression to explore the neurotransmitters involved, the alterations in neuroreceptors, non-neuroreceptor targets (e.g., microglia and astrocytes), th...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1322118/full |
| _version_ | 1797198720322764800 |
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| author | Shashi B. Singh Atit Tiwari Maanya R. Katta Riju Kafle Cyrus Ayubcha Cyrus Ayubcha Krishna H. Patel Yash Bhattarai Thomas J. Werner Abass Alavi Mona-Elisabeth Revheim Mona-Elisabeth Revheim |
| author_facet | Shashi B. Singh Atit Tiwari Maanya R. Katta Riju Kafle Cyrus Ayubcha Cyrus Ayubcha Krishna H. Patel Yash Bhattarai Thomas J. Werner Abass Alavi Mona-Elisabeth Revheim Mona-Elisabeth Revheim |
| author_sort | Shashi B. Singh |
| collection | DOAJ |
| description | This educational review article aims to discuss growing evidence from PET studies in the diagnosis and treatment of depression. PET has been used in depression to explore the neurotransmitters involved, the alterations in neuroreceptors, non-neuroreceptor targets (e.g., microglia and astrocytes), the severity and duration of the disease, the pharmacodynamics of various antidepressants, and neurobiological mechanisms of non-pharmacological therapies like psychotherapy, electroconvulsive therapy, and deep brain stimulation therapy, by showing changes in brain metabolism and receptor and non-receptor targets. Studies have revealed alterations in neurotransmitter systems such as serotonin, dopamine, GABA, and glutamate, which are linked to the pathophysiology of depression. Overall, PET imaging has furthered the neurobiological understanding of depression. Despite these advancements, PET findings have not yet led to significant changes in evidence-based practices. Addressing the reasons behind inconsistencies in PET imaging results, conducting large sample size studies with a more standardized methodological approach, and investigating further the genetic and neurobiological aspects of depression may better leverage PET imaging in future studies. |
| first_indexed | 2024-04-24T07:04:21Z |
| format | Article |
| id | doaj.art-79cf6a092561477cb2524dac537da9d7 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-24T07:04:21Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-79cf6a092561477cb2524dac537da9d72024-04-22T05:19:01ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402024-04-011510.3389/fpsyt.2024.13221181322118The utility of PET imaging in depressionShashi B. Singh0Atit Tiwari1Maanya R. Katta2Riju Kafle3Cyrus Ayubcha4Cyrus Ayubcha5Krishna H. Patel6Yash Bhattarai7Thomas J. Werner8Abass Alavi9Mona-Elisabeth Revheim10Mona-Elisabeth Revheim11Department of Radiology, Stanford University School of Medicine, Stanford, CA, United StatesBP Koirala Institute of Health Sciences, Dharan, NepalUniversity of La Verne, La Verne, CA, United StatesRhythm Neuropsychiatry Hospital and Research Center Pvt. Ltd, Lalitpur, NepalHarvard Medical School, Boston, MA, United StatesDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United StatesIcahn School of Medicine at Mount Sinai, New York City, NY, United StatesCase Western Reserve University/The MetroHealth System, Cleveland, OH, United StatesDepartment of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, United StatesDepartment of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, United States0The Intervention Center, Division of Technology and Innovation, Oslo University Hospital, Oslo, Norway1Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, NorwayThis educational review article aims to discuss growing evidence from PET studies in the diagnosis and treatment of depression. PET has been used in depression to explore the neurotransmitters involved, the alterations in neuroreceptors, non-neuroreceptor targets (e.g., microglia and astrocytes), the severity and duration of the disease, the pharmacodynamics of various antidepressants, and neurobiological mechanisms of non-pharmacological therapies like psychotherapy, electroconvulsive therapy, and deep brain stimulation therapy, by showing changes in brain metabolism and receptor and non-receptor targets. Studies have revealed alterations in neurotransmitter systems such as serotonin, dopamine, GABA, and glutamate, which are linked to the pathophysiology of depression. Overall, PET imaging has furthered the neurobiological understanding of depression. Despite these advancements, PET findings have not yet led to significant changes in evidence-based practices. Addressing the reasons behind inconsistencies in PET imaging results, conducting large sample size studies with a more standardized methodological approach, and investigating further the genetic and neurobiological aspects of depression may better leverage PET imaging in future studies.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1322118/fulldepressionPETantidepressantFDGserotoninamyloid |
| spellingShingle | Shashi B. Singh Atit Tiwari Maanya R. Katta Riju Kafle Cyrus Ayubcha Cyrus Ayubcha Krishna H. Patel Yash Bhattarai Thomas J. Werner Abass Alavi Mona-Elisabeth Revheim Mona-Elisabeth Revheim The utility of PET imaging in depression Frontiers in Psychiatry depression PET antidepressant FDG serotonin amyloid |
| title | The utility of PET imaging in depression |
| title_full | The utility of PET imaging in depression |
| title_fullStr | The utility of PET imaging in depression |
| title_full_unstemmed | The utility of PET imaging in depression |
| title_short | The utility of PET imaging in depression |
| title_sort | utility of pet imaging in depression |
| topic | depression PET antidepressant FDG serotonin amyloid |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1322118/full |
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