MicroRNAs in idiopathic pulmonary fibrosis: involvement in pathogenesis and potential use in diagnosis and therapeutics
MicroRNAs (miRNAs) are a class of phylogenetically conserved, non-coding short RNAs, 19–22 nt in length which suppress protein expression through base-pairing with the 3′-untranslated region of target mRNAs. miRNAs have been found to participate in cell proliferation, differentiation and apoptosis....
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016-10-01
|
| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383516300624 |
| _version_ | 1819207992894029824 |
|---|---|
| author | Huimin Li Xiaoguang Zhao Hongli Shan Haihai Liang |
| author_facet | Huimin Li Xiaoguang Zhao Hongli Shan Haihai Liang |
| author_sort | Huimin Li |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) are a class of phylogenetically conserved, non-coding short RNAs, 19–22 nt in length which suppress protein expression through base-pairing with the 3′-untranslated region of target mRNAs. miRNAs have been found to participate in cell proliferation, differentiation and apoptosis. Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and high lethality fibrotic lung disease for which currently there is no effective treatment. Some miRNAs have been reported to be involved in the pathogenesis of pulmonary fibrosis. In this review, we discuss the role of miRNAs in the pathogenesis, diagnosis and treatment of IPF. |
| first_indexed | 2024-12-23T05:32:19Z |
| format | Article |
| id | doaj.art-79d00afc70524ae9aee8252e71b4a7b1 |
| institution | Directory Open Access Journal |
| issn | 2211-3835 2211-3843 |
| language | English |
| last_indexed | 2024-12-23T05:32:19Z |
| publishDate | 2016-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-79d00afc70524ae9aee8252e71b4a7b12022-12-21T17:58:27ZengElsevierActa Pharmaceutica Sinica B2211-38352211-38432016-10-016653153910.1016/j.apsb.2016.06.010MicroRNAs in idiopathic pulmonary fibrosis: involvement in pathogenesis and potential use in diagnosis and therapeuticsHuimin LiXiaoguang ZhaoHongli ShanHaihai LiangMicroRNAs (miRNAs) are a class of phylogenetically conserved, non-coding short RNAs, 19–22 nt in length which suppress protein expression through base-pairing with the 3′-untranslated region of target mRNAs. miRNAs have been found to participate in cell proliferation, differentiation and apoptosis. Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and high lethality fibrotic lung disease for which currently there is no effective treatment. Some miRNAs have been reported to be involved in the pathogenesis of pulmonary fibrosis. In this review, we discuss the role of miRNAs in the pathogenesis, diagnosis and treatment of IPF.http://www.sciencedirect.com/science/article/pii/S2211383516300624Idiopathic pulmonary fibrosisMicroRNAPathogenesisEarly diagnosisTherapeutic targetlncRNA |
| spellingShingle | Huimin Li Xiaoguang Zhao Hongli Shan Haihai Liang MicroRNAs in idiopathic pulmonary fibrosis: involvement in pathogenesis and potential use in diagnosis and therapeutics Acta Pharmaceutica Sinica B Idiopathic pulmonary fibrosis MicroRNA Pathogenesis Early diagnosis Therapeutic target lncRNA |
| title | MicroRNAs in idiopathic pulmonary fibrosis: involvement in pathogenesis and potential use in diagnosis and therapeutics |
| title_full | MicroRNAs in idiopathic pulmonary fibrosis: involvement in pathogenesis and potential use in diagnosis and therapeutics |
| title_fullStr | MicroRNAs in idiopathic pulmonary fibrosis: involvement in pathogenesis and potential use in diagnosis and therapeutics |
| title_full_unstemmed | MicroRNAs in idiopathic pulmonary fibrosis: involvement in pathogenesis and potential use in diagnosis and therapeutics |
| title_short | MicroRNAs in idiopathic pulmonary fibrosis: involvement in pathogenesis and potential use in diagnosis and therapeutics |
| title_sort | micrornas in idiopathic pulmonary fibrosis involvement in pathogenesis and potential use in diagnosis and therapeutics |
| topic | Idiopathic pulmonary fibrosis MicroRNA Pathogenesis Early diagnosis Therapeutic target lncRNA |
| url | http://www.sciencedirect.com/science/article/pii/S2211383516300624 |
| work_keys_str_mv | AT huiminli micrornasinidiopathicpulmonaryfibrosisinvolvementinpathogenesisandpotentialuseindiagnosisandtherapeutics AT xiaoguangzhao micrornasinidiopathicpulmonaryfibrosisinvolvementinpathogenesisandpotentialuseindiagnosisandtherapeutics AT honglishan micrornasinidiopathicpulmonaryfibrosisinvolvementinpathogenesisandpotentialuseindiagnosisandtherapeutics AT haihailiang micrornasinidiopathicpulmonaryfibrosisinvolvementinpathogenesisandpotentialuseindiagnosisandtherapeutics |