BMP7 ameliorates intervertebral disc degeneration in type 1 diabetic rats by inhibiting pyroptosis of nucleus pulposus cells and NLRP3 inflammasome activity

BMP7 ameliorates intervertebral disc degeneration in type 1 diabetic rats by inhibiting pyroptosis of nucleus pulposus cells and NLRP3 inflammasome activity

Abstract Background Accumulating evidence indicates that intervertebral disc degeneration (IDD) is associated with diabetes mellitus (DM), while the underlying mechanisms still remain elusive. Herein, the current study sought to explore the potential molecular mechanism of IDD in diabetic rats based...

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Bibliographic Details
Main Authors: Xiao-Jun Yu, Ying-Guang Wang, Rui Lu, Xin-Zhen Guo, Yun-Kun Qu, Shan-Xi Wang, Hao-Ran Xu, Hao Kang, Hong-Bo You, Yong Xu
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Molecular Medicine
Subjects:
Intervertebral disc degeneration
Type 1 diabetes mellitus
BMP7
Pyroptosis
Nucleus pulposus cell
NLRP3 inflammasome activity
Online Access:https://doi.org/10.1186/s10020-023-00623-8

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