Exploring the Impact of Exosomal Cargos on Osteosarcoma Progression: Insights into Therapeutic Potential
Osteosarcoma (OS) is a primary malignant bone tumor with high metastasis. Poor prognosis highlights a clinical need for novel therapeutic strategies. Exosomes, also known as extracellular vesicles, have been identified as essential players in the modulation of cancer. Recent studies have suggested t...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/1/568 |
| _version_ | 1797358667695128576 |
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| author | Claire C. Chen Claudia A. Benavente |
| author_facet | Claire C. Chen Claudia A. Benavente |
| author_sort | Claire C. Chen |
| collection | DOAJ |
| description | Osteosarcoma (OS) is a primary malignant bone tumor with high metastasis. Poor prognosis highlights a clinical need for novel therapeutic strategies. Exosomes, also known as extracellular vesicles, have been identified as essential players in the modulation of cancer. Recent studies have suggested that OS-derived exosomes can drive pro-tumorigenic or anti-tumorigenic phenotypes by transferring specific cargos, including proteins, nucleic acids, and metabolites, to neighboring cells, significantly impacting the regulation of cellular processes. This review discusses the advancement of exosomes and their cargos in OS. We examine how these exosomes contribute to the modulation of cellular phenotypes associated with tumor progression and metastasis. Furthermore, we explore the potential of exosomes as valuable biomarkers for diagnostics and prognostic purposes and their role in shaping innovative therapeutic strategies in OS treatment development. |
| first_indexed | 2024-03-08T15:04:41Z |
| format | Article |
| id | doaj.art-79d429ee8fdf45009a632e65cd18cba6 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T15:04:41Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-79d429ee8fdf45009a632e65cd18cba62024-01-10T15:00:01ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-01-0125156810.3390/ijms25010568Exploring the Impact of Exosomal Cargos on Osteosarcoma Progression: Insights into Therapeutic PotentialClaire C. Chen0Claudia A. Benavente1Department of Pharmaceutical Sciences, University of California, Irvine, CA 92697, USADepartment of Pharmaceutical Sciences, University of California, Irvine, CA 92697, USAOsteosarcoma (OS) is a primary malignant bone tumor with high metastasis. Poor prognosis highlights a clinical need for novel therapeutic strategies. Exosomes, also known as extracellular vesicles, have been identified as essential players in the modulation of cancer. Recent studies have suggested that OS-derived exosomes can drive pro-tumorigenic or anti-tumorigenic phenotypes by transferring specific cargos, including proteins, nucleic acids, and metabolites, to neighboring cells, significantly impacting the regulation of cellular processes. This review discusses the advancement of exosomes and their cargos in OS. We examine how these exosomes contribute to the modulation of cellular phenotypes associated with tumor progression and metastasis. Furthermore, we explore the potential of exosomes as valuable biomarkers for diagnostics and prognostic purposes and their role in shaping innovative therapeutic strategies in OS treatment development.https://www.mdpi.com/1422-0067/25/1/568exosomesextracellular vesiclesosteosarcoma |
| spellingShingle | Claire C. Chen Claudia A. Benavente Exploring the Impact of Exosomal Cargos on Osteosarcoma Progression: Insights into Therapeutic Potential International Journal of Molecular Sciences exosomes extracellular vesicles osteosarcoma |
| title | Exploring the Impact of Exosomal Cargos on Osteosarcoma Progression: Insights into Therapeutic Potential |
| title_full | Exploring the Impact of Exosomal Cargos on Osteosarcoma Progression: Insights into Therapeutic Potential |
| title_fullStr | Exploring the Impact of Exosomal Cargos on Osteosarcoma Progression: Insights into Therapeutic Potential |
| title_full_unstemmed | Exploring the Impact of Exosomal Cargos on Osteosarcoma Progression: Insights into Therapeutic Potential |
| title_short | Exploring the Impact of Exosomal Cargos on Osteosarcoma Progression: Insights into Therapeutic Potential |
| title_sort | exploring the impact of exosomal cargos on osteosarcoma progression insights into therapeutic potential |
| topic | exosomes extracellular vesicles osteosarcoma |
| url | https://www.mdpi.com/1422-0067/25/1/568 |
| work_keys_str_mv | AT clairecchen exploringtheimpactofexosomalcargosonosteosarcomaprogressioninsightsintotherapeuticpotential AT claudiaabenavente exploringtheimpactofexosomalcargosonosteosarcomaprogressioninsightsintotherapeuticpotential |