Pseudoepitheliomatous Hyperplasia: Harbinger of Underlying Squamous Cell Carcinoma - Lessons Learnt
Pseudoepitheliomatous hyperplasia (PEH) is a benign condition marked by reactive epithelial proliferation seen in response to various insults like trauma, infection, persistent inflammation and neoplasia. In this report, we discuss a case of a 35-year-old man who presented with a perineal swelling,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Asian Medical Press Ltd.(H.K.)
2022-12-01
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| Series: | Annals of Urologic Oncology |
| Subjects: | |
| Online Access: | http://auo.asmepress.com/articles/new-5-574.html |
| _version_ | 1797975461250203648 |
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| author | Sriram Krishnamoorthy Hariharasudhan Sekar Leena Dennis Joseph J. Sathish Kumar |
| author_facet | Sriram Krishnamoorthy Hariharasudhan Sekar Leena Dennis Joseph J. Sathish Kumar |
| author_sort | Sriram Krishnamoorthy |
| collection | DOAJ |
| description | Pseudoepitheliomatous hyperplasia (PEH) is a benign condition marked by reactive epithelial proliferation seen in response to various insults like trauma, infection, persistent inflammation and neoplasia. In this report, we discuss a case of a 35-year-old man who presented with a perineal swelling, later turned into a non-healing ulcer, first diagnosed as PEH. Still, after clinical suspicion, a deeper biopsy was conducted, confirming the diagnosis of squamous cell carcinoma and directing treatment appropriately.
Non-healing perineal lesions are not uncommon. Most of the lesions turn out to be Squamous Cell Carcinoma. But, if the histopathological picture suggests Pseudoepitheliomatous Hyperplasia, it is vital to consider the limitations of the biopsy, and a solid clinicopathological correlation is required to look aggressively for underlying Squamous Cell Carcinoma. Due to the benign nature of PEH, most cases are treated via excision biopsy, while grafts or flaps are occasionally required to restore severe tissue defects.
It is therefore crucial to rule out and distinguish this condition from other benign and malignant conditions, as the treatment and prognosis differ widely. It is of utmost importance to sample the base of the lesion, analyze multiple sections, and consider clinical data to ensure an accurate diagnosis. |
| first_indexed | 2024-04-11T04:35:54Z |
| format | Article |
| id | doaj.art-79d47a9d435345f68200e2bc1bd6433c |
| institution | Directory Open Access Journal |
| issn | 2617-7765 2617-7773 |
| language | English |
| last_indexed | 2024-04-11T04:35:54Z |
| publishDate | 2022-12-01 |
| publisher | Asian Medical Press Ltd.(H.K.) |
| record_format | Article |
| series | Annals of Urologic Oncology |
| spelling | doaj.art-79d47a9d435345f68200e2bc1bd6433c2022-12-28T15:34:58ZengAsian Medical Press Ltd.(H.K.)Annals of Urologic Oncology2617-77652617-77732022-12-0151525610.32948/auo.2022.12.22Pseudoepitheliomatous Hyperplasia: Harbinger of Underlying Squamous Cell Carcinoma - Lessons LearntSriram Krishnamoorthy0Hariharasudhan Sekar1Leena Dennis Joseph2 J. Sathish Kumar3Department of Urology & Renal Transplantation, Sri Ramachandra Institute of Higher Education & Research (SRIHER), Chennai, India.Department of Urology & Renal Transplantation, Sri Ramachandra Institute of Higher Education & Research (SRIHER), Chennai, India.Department of Pathology, SRIHER, Chennai, India.Department of Plastic Surgery, SRIHER, Chennai, India.Pseudoepitheliomatous hyperplasia (PEH) is a benign condition marked by reactive epithelial proliferation seen in response to various insults like trauma, infection, persistent inflammation and neoplasia. In this report, we discuss a case of a 35-year-old man who presented with a perineal swelling, later turned into a non-healing ulcer, first diagnosed as PEH. Still, after clinical suspicion, a deeper biopsy was conducted, confirming the diagnosis of squamous cell carcinoma and directing treatment appropriately. Non-healing perineal lesions are not uncommon. Most of the lesions turn out to be Squamous Cell Carcinoma. But, if the histopathological picture suggests Pseudoepitheliomatous Hyperplasia, it is vital to consider the limitations of the biopsy, and a solid clinicopathological correlation is required to look aggressively for underlying Squamous Cell Carcinoma. Due to the benign nature of PEH, most cases are treated via excision biopsy, while grafts or flaps are occasionally required to restore severe tissue defects. It is therefore crucial to rule out and distinguish this condition from other benign and malignant conditions, as the treatment and prognosis differ widely. It is of utmost importance to sample the base of the lesion, analyze multiple sections, and consider clinical data to ensure an accurate diagnosis.http://auo.asmepress.com/articles/new-5-574.htmlsquamous cell carcinomapseudoepitheliomatous hyperplasiaperineumulcer |
| spellingShingle | Sriram Krishnamoorthy Hariharasudhan Sekar Leena Dennis Joseph J. Sathish Kumar Pseudoepitheliomatous Hyperplasia: Harbinger of Underlying Squamous Cell Carcinoma - Lessons Learnt Annals of Urologic Oncology squamous cell carcinoma pseudoepitheliomatous hyperplasia perineum ulcer |
| title | Pseudoepitheliomatous Hyperplasia: Harbinger of Underlying Squamous Cell Carcinoma - Lessons Learnt |
| title_full | Pseudoepitheliomatous Hyperplasia: Harbinger of Underlying Squamous Cell Carcinoma - Lessons Learnt |
| title_fullStr | Pseudoepitheliomatous Hyperplasia: Harbinger of Underlying Squamous Cell Carcinoma - Lessons Learnt |
| title_full_unstemmed | Pseudoepitheliomatous Hyperplasia: Harbinger of Underlying Squamous Cell Carcinoma - Lessons Learnt |
| title_short | Pseudoepitheliomatous Hyperplasia: Harbinger of Underlying Squamous Cell Carcinoma - Lessons Learnt |
| title_sort | pseudoepitheliomatous hyperplasia harbinger of underlying squamous cell carcinoma lessons learnt |
| topic | squamous cell carcinoma pseudoepitheliomatous hyperplasia perineum ulcer |
| url | http://auo.asmepress.com/articles/new-5-574.html |
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