TNF‐α polymorphisms affect persistence and progression of HBV infection
Abstract Background Hepatitis B virus (HBV) infections are a major threat worldwide. Disease progression and outcome is diverse and depends on host genetic background. Recently, a high rate of HBV reactivation in individuals receiving tumor necrosis factor‐α (TNF‐α) antagonists showed the importance...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-10-01
|
| Series: | Molecular Genetics & Genomic Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mgg3.935 |
| _version_ | 1797301064741945344 |
|---|---|
| author | Anna Woziwodzka Magda Rybicka Alicja Sznarkowska Tomasz Romanowski Marcin Dręczewski Piotr Stalke Krzysztof Piotr Bielawski |
| author_facet | Anna Woziwodzka Magda Rybicka Alicja Sznarkowska Tomasz Romanowski Marcin Dręczewski Piotr Stalke Krzysztof Piotr Bielawski |
| author_sort | Anna Woziwodzka |
| collection | DOAJ |
| description | Abstract Background Hepatitis B virus (HBV) infections are a major threat worldwide. Disease progression and outcome is diverse and depends on host genetic background. Recently, a high rate of HBV reactivation in individuals receiving tumor necrosis factor‐α (TNF‐α) antagonists showed the importance of this cytokine in HBV infection control. Here, we investigated the influence of TNF‐α promoter polymorphisms on susceptibility to chronic HBV infection (CHB), liver injury progression and outcomes. Methods A total of 231 patients with CHB constituted the study group and 100 healthy volunteers—the local control group. TNF‐α −1031T/C, −863C/A, −857C/T, −308G/A, and −238G/A were genotyped using MALDI‐TOF mass spectrometry. Results TNF‐α −1031C and −863A alleles were observed more frequently in CHB group than in healthy controls. Carriers of TNF‐α −1031C and −863A variant alleles had lower baseline levels of serum HBV DNA and lower liver necroinflammatory activity than dominant homozygotes. A −857CT genotype predisposed to higher necroinflammatory activity. No associations between TNF‐α variants and liver fibrosis were found. Conclusion This study indicates that TNF‐α −863A and −1031C alleles are associated with increased susceptibility to CHB in individuals from northern Poland. The same variants determine the course of CHB, lowering viremia and reducing necroinflammatory activity of the liver. |
| first_indexed | 2024-03-07T23:17:01Z |
| format | Article |
| id | doaj.art-79d4ba756ef242d899bd8de06e3fc271 |
| institution | Directory Open Access Journal |
| issn | 2324-9269 |
| language | English |
| last_indexed | 2024-03-07T23:17:01Z |
| publishDate | 2019-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Genetics & Genomic Medicine |
| spelling | doaj.art-79d4ba756ef242d899bd8de06e3fc2712024-02-21T10:29:27ZengWileyMolecular Genetics & Genomic Medicine2324-92692019-10-01710n/an/a10.1002/mgg3.935TNF‐α polymorphisms affect persistence and progression of HBV infectionAnna Woziwodzka0Magda Rybicka1Alicja Sznarkowska2Tomasz Romanowski3Marcin Dręczewski4Piotr Stalke5Krzysztof Piotr Bielawski6Department of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology University of Gdansk and Medical University of Gdansk Gdansk PolandDepartment of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology University of Gdansk and Medical University of Gdansk Gdansk PolandDepartment of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology University of Gdansk and Medical University of Gdansk Gdansk PolandDepartment of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology University of Gdansk and Medical University of Gdansk Gdansk PolandDepartment of Infectious Diseases Medical University of Gdansk Gdynia PolandDepartment of Infectious Diseases Medical University of Gdansk Gdynia PolandDepartment of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology University of Gdansk and Medical University of Gdansk Gdansk PolandAbstract Background Hepatitis B virus (HBV) infections are a major threat worldwide. Disease progression and outcome is diverse and depends on host genetic background. Recently, a high rate of HBV reactivation in individuals receiving tumor necrosis factor‐α (TNF‐α) antagonists showed the importance of this cytokine in HBV infection control. Here, we investigated the influence of TNF‐α promoter polymorphisms on susceptibility to chronic HBV infection (CHB), liver injury progression and outcomes. Methods A total of 231 patients with CHB constituted the study group and 100 healthy volunteers—the local control group. TNF‐α −1031T/C, −863C/A, −857C/T, −308G/A, and −238G/A were genotyped using MALDI‐TOF mass spectrometry. Results TNF‐α −1031C and −863A alleles were observed more frequently in CHB group than in healthy controls. Carriers of TNF‐α −1031C and −863A variant alleles had lower baseline levels of serum HBV DNA and lower liver necroinflammatory activity than dominant homozygotes. A −857CT genotype predisposed to higher necroinflammatory activity. No associations between TNF‐α variants and liver fibrosis were found. Conclusion This study indicates that TNF‐α −863A and −1031C alleles are associated with increased susceptibility to CHB in individuals from northern Poland. The same variants determine the course of CHB, lowering viremia and reducing necroinflammatory activity of the liver.https://doi.org/10.1002/mgg3.935chronic hepatitis Bhost factormass spectrometrysingle‐nucleotide polymorphismtumor necrosis factor‐α |
| spellingShingle | Anna Woziwodzka Magda Rybicka Alicja Sznarkowska Tomasz Romanowski Marcin Dręczewski Piotr Stalke Krzysztof Piotr Bielawski TNF‐α polymorphisms affect persistence and progression of HBV infection Molecular Genetics & Genomic Medicine chronic hepatitis B host factor mass spectrometry single‐nucleotide polymorphism tumor necrosis factor‐α |
| title | TNF‐α polymorphisms affect persistence and progression of HBV infection |
| title_full | TNF‐α polymorphisms affect persistence and progression of HBV infection |
| title_fullStr | TNF‐α polymorphisms affect persistence and progression of HBV infection |
| title_full_unstemmed | TNF‐α polymorphisms affect persistence and progression of HBV infection |
| title_short | TNF‐α polymorphisms affect persistence and progression of HBV infection |
| title_sort | tnf α polymorphisms affect persistence and progression of hbv infection |
| topic | chronic hepatitis B host factor mass spectrometry single‐nucleotide polymorphism tumor necrosis factor‐α |
| url | https://doi.org/10.1002/mgg3.935 |
| work_keys_str_mv | AT annawoziwodzka tnfapolymorphismsaffectpersistenceandprogressionofhbvinfection AT magdarybicka tnfapolymorphismsaffectpersistenceandprogressionofhbvinfection AT alicjasznarkowska tnfapolymorphismsaffectpersistenceandprogressionofhbvinfection AT tomaszromanowski tnfapolymorphismsaffectpersistenceandprogressionofhbvinfection AT marcindreczewski tnfapolymorphismsaffectpersistenceandprogressionofhbvinfection AT piotrstalke tnfapolymorphismsaffectpersistenceandprogressionofhbvinfection AT krzysztofpiotrbielawski tnfapolymorphismsaffectpersistenceandprogressionofhbvinfection |