Utility of sFtl-1 and Placental Growth Factor Ratio for Adequate Preeclampsia Management
<b>Introduction:</b> The pathophysiology of preeclampsia is represented by placental ischemia and the release of angiogenic factors. Recent research suggests that using the value of the sFtl-1/PIGF ratio is more accurate for monitoring angiogenic activity. The aim of this study consists...
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MDPI AG
2023-01-01
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| Online Access: | https://www.mdpi.com/2227-9032/11/3/381 |
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| author | Elena Ciciu Ana-Maria Paṣatu-Cornea Stefania Dumitru Lucian Cristian Petcu Camer Salim Liliana-Ana Tuta |
| author_facet | Elena Ciciu Ana-Maria Paṣatu-Cornea Stefania Dumitru Lucian Cristian Petcu Camer Salim Liliana-Ana Tuta |
| author_sort | Elena Ciciu |
| collection | DOAJ |
| description | <b>Introduction:</b> The pathophysiology of preeclampsia is represented by placental ischemia and the release of angiogenic factors. Recent research suggests that using the value of the sFtl-1/PIGF ratio is more accurate for monitoring angiogenic activity. The aim of this study consists in assessing the clinical utility of the sFtl-1/PIGF ratio in determining the diagnosis and severity of preeclampsia. <b>Material and Methods:</b> In our study a descriptive and prospective plan was used for analyzing the specific value of the sFtl-1/PIGF ratio in women with preeclampsia and in women with gestational hypertension, depending on the gestational age and severity. <b>Results:</b> The study included 59 women with preeclampsia and 25 women with gestational hypertension. The mean value of the sFtl-1/PIGF ratio of pregnant women with preeclampsia was 209.2 pg/mL, while in the gestational hypertension group, the mean value of the sFtl-1/PIGF ratio was 46.08 pg/mL. The difference between the value of the sFtl-1/PIGF ratio of the group with preeclampsia and the gestational hypertension group was > 67 (pg/mL), with a sensitivity of 86.44% and a specificity of 92.00%. Significant differences were found between the median values of the sFtl-1/PIGF ratio in pregnant women with severe preeclampsia in the early-onset subgroup compared to those in the late-onset subgroup (307 pg/mL, and 98 pg/mL, respectively, <i>p</i> = 0.009 < α = 0.05). <b>Conclusions:</b> The sFtl-1/PIGF ratio may be an alternative method for diagnosing preeclampsia and it can provide data about this condition’s severity. |
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| language | English |
| last_indexed | 2024-03-11T09:43:59Z |
| publishDate | 2023-01-01 |
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| series | Healthcare |
| spelling | doaj.art-79d51a8cfeed40e4a929b8385ed3542c2023-11-16T16:44:32ZengMDPI AGHealthcare2227-90322023-01-0111338110.3390/healthcare11030381Utility of sFtl-1 and Placental Growth Factor Ratio for Adequate Preeclampsia ManagementElena Ciciu0Ana-Maria Paṣatu-Cornea1Stefania Dumitru2Lucian Cristian Petcu3Camer Salim4Liliana-Ana Tuta5Nephrology Department, Constanta County Emergency Hospital, 900591 Constanţa, RomaniaNephrology Department, Constanta County Emergency Hospital, 900591 Constanţa, RomaniaNephrology Department, Constanta County Emergency Hospital, 900591 Constanţa, RomaniaDepartment of Biophysics and Biostatics, Faculty of Dental Medicine, Ovidius University of Constanţa, 900527 Constanţa, RomaniaEmergency Department, Constanta County Emergency Hospital, 900601 Constanta, RomaniaNephrology Department, Constanta County Emergency Hospital, 900591 Constanţa, Romania<b>Introduction:</b> The pathophysiology of preeclampsia is represented by placental ischemia and the release of angiogenic factors. Recent research suggests that using the value of the sFtl-1/PIGF ratio is more accurate for monitoring angiogenic activity. The aim of this study consists in assessing the clinical utility of the sFtl-1/PIGF ratio in determining the diagnosis and severity of preeclampsia. <b>Material and Methods:</b> In our study a descriptive and prospective plan was used for analyzing the specific value of the sFtl-1/PIGF ratio in women with preeclampsia and in women with gestational hypertension, depending on the gestational age and severity. <b>Results:</b> The study included 59 women with preeclampsia and 25 women with gestational hypertension. The mean value of the sFtl-1/PIGF ratio of pregnant women with preeclampsia was 209.2 pg/mL, while in the gestational hypertension group, the mean value of the sFtl-1/PIGF ratio was 46.08 pg/mL. The difference between the value of the sFtl-1/PIGF ratio of the group with preeclampsia and the gestational hypertension group was > 67 (pg/mL), with a sensitivity of 86.44% and a specificity of 92.00%. Significant differences were found between the median values of the sFtl-1/PIGF ratio in pregnant women with severe preeclampsia in the early-onset subgroup compared to those in the late-onset subgroup (307 pg/mL, and 98 pg/mL, respectively, <i>p</i> = 0.009 < α = 0.05). <b>Conclusions:</b> The sFtl-1/PIGF ratio may be an alternative method for diagnosing preeclampsia and it can provide data about this condition’s severity.https://www.mdpi.com/2227-9032/11/3/381pregnancypreeclampsiagestational hypertensionbiomarkerssFtl-1/PIGF ratio |
| spellingShingle | Elena Ciciu Ana-Maria Paṣatu-Cornea Stefania Dumitru Lucian Cristian Petcu Camer Salim Liliana-Ana Tuta Utility of sFtl-1 and Placental Growth Factor Ratio for Adequate Preeclampsia Management Healthcare pregnancy preeclampsia gestational hypertension biomarkers sFtl-1/PIGF ratio |
| title | Utility of sFtl-1 and Placental Growth Factor Ratio for Adequate Preeclampsia Management |
| title_full | Utility of sFtl-1 and Placental Growth Factor Ratio for Adequate Preeclampsia Management |
| title_fullStr | Utility of sFtl-1 and Placental Growth Factor Ratio for Adequate Preeclampsia Management |
| title_full_unstemmed | Utility of sFtl-1 and Placental Growth Factor Ratio for Adequate Preeclampsia Management |
| title_short | Utility of sFtl-1 and Placental Growth Factor Ratio for Adequate Preeclampsia Management |
| title_sort | utility of sftl 1 and placental growth factor ratio for adequate preeclampsia management |
| topic | pregnancy preeclampsia gestational hypertension biomarkers sFtl-1/PIGF ratio |
| url | https://www.mdpi.com/2227-9032/11/3/381 |
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