Synergistic Induction of Cyclooxygenase-2 by Transforming Growth Factor-β1 and Epidermal Growth Factor Inhibits Apoptosis in Epithelial Cells

Synergistic Induction of Cyclooxygenase-2 by Transforming Growth Factor-β1 and Epidermal Growth Factor Inhibits Apoptosis in Epithelial Cells

Increased expression of cyclooxygenase-2 (COX-2) expression has been observed in several human tumor types and in selected animal and cell culture models of carcinogenesis, including lung cancer. Increased expression of COX-2 and production of prostaglandins appear to provide a survival advantage to...

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Bibliographic Details
Main Authors: Debabrata Saha, Pran K. Datta, Hongmiao Sheng, Jason D. Morrow, Michihiko Wada, Harold L. Moses, R. Daniel Beauchamp
Format: Article
Language:English
Published: Elsevier 1999-12-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
COX-2
TGF-β
EGF
apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558699800049

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