DPP in the matrix activates AKT and mTOR signaling pathway to promote preodontoblast survival and differentiation

DPP in the matrix activates AKT and mTOR signaling pathway to promote preodontoblast survival and differentiation

Dentin phosphophoryn (DPP) is an extracellular matrix protein synthesized by odontoblasts. It is highly acidic and the phosphorylated protein possesses a strong affinity for calcium ions. Therefore, DPP in the extracellular matrix can promote hydroxyapatite nucleation and can regulate the size of th...

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Bibliographic Details
Main Authors: ANNE eGEORGE, Asha eEapen
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Physiology
Subjects:
Cell Proliferation
Odontoblasts
differentiation
signaling
Dentin phosphophoryn
pereodontoblasts
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00221/full

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