A novel aquaporin-4-associated optic neuritis rat model with severe pathological and functional manifestations
Abstract Background Optic neuritis (ON) is a common manifestation of aquaporin-4 (AQP4) antibody seropositive neuromyelitis optica (NMO). The extent of tissue damage is frequently severe, often leading to loss of visual function, and there is no curative treatment for this condition. To develop a no...
Main Authors: | Yuko Morita, Takahide Itokazu, Toru Nakanishi, Shin-ichiro Hiraga, Toshihide Yamashita |
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Format: | Article |
Language: | English |
Published: |
BMC
2022-10-01
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Series: | Journal of Neuroinflammation |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12974-022-02623-7 |
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