A novel aquaporin-4-associated optic neuritis rat model with severe pathological and functional manifestations

A novel aquaporin-4-associated optic neuritis rat model with severe pathological and functional manifestations

Abstract Background Optic neuritis (ON) is a common manifestation of aquaporin-4 (AQP4) antibody seropositive neuromyelitis optica (NMO). The extent of tissue damage is frequently severe, often leading to loss of visual function, and there is no curative treatment for this condition. To develop a no...

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Bibliographic Details
Main Authors: Yuko Morita, Takahide Itokazu, Toru Nakanishi, Shin-ichiro Hiraga, Toshihide Yamashita
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Journal of Neuroinflammation
Subjects:
Neuromyelitis optica
Axonal degeneration
Neuroinflammation
Macrophages/microglia activation
Minocycline
Optic neuritis
Online Access:https://doi.org/10.1186/s12974-022-02623-7

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