The role of melatonin in the development of postmenopausal osteoporosis
Melatonin is an important endogenous hormone that modulates homeostasis in the microenvironment. Recent studies have indicated that serum melatonin levels are closely associated with the occurrence and development of osteoporosis in postmenopausal women. Exogenous melatonin could also improve bone m...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.975181/full |
| _version_ | 1828194999670407168 |
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| author | Keda Yang Xueshan Qiu Lili Cao Shui Qiu |
| author_facet | Keda Yang Xueshan Qiu Lili Cao Shui Qiu |
| author_sort | Keda Yang |
| collection | DOAJ |
| description | Melatonin is an important endogenous hormone that modulates homeostasis in the microenvironment. Recent studies have indicated that serum melatonin levels are closely associated with the occurrence and development of osteoporosis in postmenopausal women. Exogenous melatonin could also improve bone mass and increase skeletal strength. To determine the underlying mechanisms of melatonin in the prevention and treatment of postmenopausal osteoporosis, we performed this review to analyze the role of melatonin in bone metabolism according to its physiological functions. Serum melatonin is related to bone mass, the measurement of which is a potential method for the diagnosis of osteoporosis. Melatonin has a direct effect on bone remodeling by promoting osteogenesis and suppressing osteoclastogenesis. Melatonin also regulates the biological rhythm of bone tissue, which benefits its osteogenic effect. Additionally, melatonin participates in the modulation of the bone microenvironment. Melatonin attenuates the damage induced by oxidative stress and inflammation on osteoblasts and prevents osteolysis from reactive oxygen species and inflammatory factors. As an alternative drug for osteoporosis, melatonin can improve the gut ecology, remodel microbiota composition, regulate substance absorption and maintain metabolic balance, all of which are beneficial to the health of bone structure. In conclusion, our review systematically demonstrates the effects of melatonin on bone metabolism. Based on the evidence in this review, melatonin will play a more important role in the diagnosis, prevention and treatment of postmenopausal osteoporosis. |
| first_indexed | 2024-04-12T09:35:43Z |
| format | Article |
| id | doaj.art-79d9d44076f94bf5aece4eaec07040e6 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T09:35:43Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-79d9d44076f94bf5aece4eaec07040e62022-12-22T03:38:15ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-10-011310.3389/fphar.2022.975181975181The role of melatonin in the development of postmenopausal osteoporosisKeda Yang0Xueshan Qiu1Lili Cao2Shui Qiu3Department of Orthopedics, First Hospital of China Medical University, Shenyang, ChinaDepartment of Pathology, The First Affiliated Hospital of China Medical University and College of Basic Medical Sciences Shenyang, Shenyang, Liaoning, ChinaDepartment of Medical Oncology, First Hospital of China Medical University, Shenyang, ChinaDepartment of Orthopedics, First Hospital of China Medical University, Shenyang, ChinaMelatonin is an important endogenous hormone that modulates homeostasis in the microenvironment. Recent studies have indicated that serum melatonin levels are closely associated with the occurrence and development of osteoporosis in postmenopausal women. Exogenous melatonin could also improve bone mass and increase skeletal strength. To determine the underlying mechanisms of melatonin in the prevention and treatment of postmenopausal osteoporosis, we performed this review to analyze the role of melatonin in bone metabolism according to its physiological functions. Serum melatonin is related to bone mass, the measurement of which is a potential method for the diagnosis of osteoporosis. Melatonin has a direct effect on bone remodeling by promoting osteogenesis and suppressing osteoclastogenesis. Melatonin also regulates the biological rhythm of bone tissue, which benefits its osteogenic effect. Additionally, melatonin participates in the modulation of the bone microenvironment. Melatonin attenuates the damage induced by oxidative stress and inflammation on osteoblasts and prevents osteolysis from reactive oxygen species and inflammatory factors. As an alternative drug for osteoporosis, melatonin can improve the gut ecology, remodel microbiota composition, regulate substance absorption and maintain metabolic balance, all of which are beneficial to the health of bone structure. In conclusion, our review systematically demonstrates the effects of melatonin on bone metabolism. Based on the evidence in this review, melatonin will play a more important role in the diagnosis, prevention and treatment of postmenopausal osteoporosis.https://www.frontiersin.org/articles/10.3389/fphar.2022.975181/fullmelatoninpostmenopausal osteoporosisbiological rhythmsantioxidantanti-inflammationimmuomodulation |
| spellingShingle | Keda Yang Xueshan Qiu Lili Cao Shui Qiu The role of melatonin in the development of postmenopausal osteoporosis Frontiers in Pharmacology melatonin postmenopausal osteoporosis biological rhythms antioxidant anti-inflammation immuomodulation |
| title | The role of melatonin in the development of postmenopausal osteoporosis |
| title_full | The role of melatonin in the development of postmenopausal osteoporosis |
| title_fullStr | The role of melatonin in the development of postmenopausal osteoporosis |
| title_full_unstemmed | The role of melatonin in the development of postmenopausal osteoporosis |
| title_short | The role of melatonin in the development of postmenopausal osteoporosis |
| title_sort | role of melatonin in the development of postmenopausal osteoporosis |
| topic | melatonin postmenopausal osteoporosis biological rhythms antioxidant anti-inflammation immuomodulation |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.975181/full |
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