Rohitukine content across the geographical distribution of Dysoxylum binectariferum Hook F. and its natural derivatives as potential sources of CDK inhibitors

Rohitukine content across the geographical distribution of Dysoxylum binectariferum Hook F. and its natural derivatives as potential sources of CDK inhibitors

Dysoxylum binectariferum is an important medicinal plant distributed in the Western Ghats of India. The species has gained international importance for its anticancer component, rohitukine, a chromone alkaloid. Flavopiridol, P-276-00 and IIIM-290 are the derivatives of rohitukine in clinical trials...

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Bibliographic Details
Main Authors: E. Varun, K. Bhakti, K. Aishwarya, R Hosur Suraj, M.R. Jagadish, P. Mohana Kumara
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Heliyon
Subjects:
Dysoxylum binectariferum
Rohitukine
HPLC
Pharmacokinetic potential
CDKs
Online Access:http://www.sciencedirect.com/science/article/pii/S240584402300676X

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