In vivo Recording Quality of Mechanically Decoupled Floating Versus Skull-Fixed Silicon-Based Neural Probes
Throughout the past decade, silicon-based neural probes have become a driving force in neural engineering. Such probes comprise sophisticated, integrated CMOS electronics which provide a large number of recording sites along slender probe shanks. Using such neural probes in a chronic setting often r...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-05-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2019.00464/full |
| _version_ | 1798046134642409472 |
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| author | Laetitia Chauvière Frederick Pothof Kai S. Gansel Johanna Klon-Lipok Arno A. A. Aarts Tobias Holzhammer Oliver Paul Oliver Paul Wolf J. Singer Wolf J. Singer Wolf J. Singer Patrick Ruther Patrick Ruther |
| author_facet | Laetitia Chauvière Frederick Pothof Kai S. Gansel Johanna Klon-Lipok Arno A. A. Aarts Tobias Holzhammer Oliver Paul Oliver Paul Wolf J. Singer Wolf J. Singer Wolf J. Singer Patrick Ruther Patrick Ruther |
| author_sort | Laetitia Chauvière |
| collection | DOAJ |
| description | Throughout the past decade, silicon-based neural probes have become a driving force in neural engineering. Such probes comprise sophisticated, integrated CMOS electronics which provide a large number of recording sites along slender probe shanks. Using such neural probes in a chronic setting often requires them to be mechanically anchored with respect to the skull. However, any relative motion between brain and implant causes recording instabilities and tissue responses such as glial scarring, thereby shielding recordable neurons from the recording sites integrated on the probe and thus decreasing the signal quality. In the current work, we present a comparison of results obtained using mechanically fixed and floating silicon neural probes chronically implanted into the cortex of a non-human primate. We demonstrate that the neural signal quality estimated by the quality of the spiking and local field potential (LFP) recordings over time is initially superior for the floating probe compared to the fixed device. Nonetheless, the skull-fixed probe also allowed long-term recording of multi-unit activity (MUA) and low frequency signals over several months, especially once pulsations of the brain were properly controlled. |
| first_indexed | 2024-04-11T23:33:25Z |
| format | Article |
| id | doaj.art-79dae8423b9947cca3aa8e14ec81915b |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-11T23:33:25Z |
| publishDate | 2019-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-79dae8423b9947cca3aa8e14ec81915b2022-12-22T03:57:03ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-05-011310.3389/fnins.2019.00464441885In vivo Recording Quality of Mechanically Decoupled Floating Versus Skull-Fixed Silicon-Based Neural ProbesLaetitia Chauvière0Frederick Pothof1Kai S. Gansel2Johanna Klon-Lipok3Arno A. A. Aarts4Tobias Holzhammer5Oliver Paul6Oliver Paul7Wolf J. Singer8Wolf J. Singer9Wolf J. Singer10Patrick Ruther11Patrick Ruther12Max Planck Institute for Brain Research, Frankfurt am Main, GermanyDepartment of Microsystems Engineering (IMTEK), University of Freiburg, Freiburg im Breisgau, GermanyMax Planck Institute for Brain Research, Frankfurt am Main, GermanyMax Planck Institute for Brain Research, Frankfurt am Main, GermanyATLAS Neuroengineering bvba, Leuven, BelgiumATLAS Neuroengineering bvba, Leuven, BelgiumDepartment of Microsystems Engineering (IMTEK), University of Freiburg, Freiburg im Breisgau, GermanyBrainLinks-BrainTools Cluster of Excellence, University of Freiburg, Freiburg im Breisgau, GermanyMax Planck Institute for Brain Research, Frankfurt am Main, GermanyErnst Strüngmann Institute for Neuroscience in Cooperation with Max Planck Society, Frankfurt am Main, GermanyFrankfurt Institute for Advanced Studies, Frankfurt am Main, GermanyDepartment of Microsystems Engineering (IMTEK), University of Freiburg, Freiburg im Breisgau, GermanyBrainLinks-BrainTools Cluster of Excellence, University of Freiburg, Freiburg im Breisgau, GermanyThroughout the past decade, silicon-based neural probes have become a driving force in neural engineering. Such probes comprise sophisticated, integrated CMOS electronics which provide a large number of recording sites along slender probe shanks. Using such neural probes in a chronic setting often requires them to be mechanically anchored with respect to the skull. However, any relative motion between brain and implant causes recording instabilities and tissue responses such as glial scarring, thereby shielding recordable neurons from the recording sites integrated on the probe and thus decreasing the signal quality. In the current work, we present a comparison of results obtained using mechanically fixed and floating silicon neural probes chronically implanted into the cortex of a non-human primate. We demonstrate that the neural signal quality estimated by the quality of the spiking and local field potential (LFP) recordings over time is initially superior for the floating probe compared to the fixed device. Nonetheless, the skull-fixed probe also allowed long-term recording of multi-unit activity (MUA) and low frequency signals over several months, especially once pulsations of the brain were properly controlled.https://www.frontiersin.org/article/10.3389/fnins.2019.00464/fullsilicon-based neural probesfloating probesfixed probesin vivo recordingnon-human primatesvisual cortex |
| spellingShingle | Laetitia Chauvière Frederick Pothof Kai S. Gansel Johanna Klon-Lipok Arno A. A. Aarts Tobias Holzhammer Oliver Paul Oliver Paul Wolf J. Singer Wolf J. Singer Wolf J. Singer Patrick Ruther Patrick Ruther In vivo Recording Quality of Mechanically Decoupled Floating Versus Skull-Fixed Silicon-Based Neural Probes Frontiers in Neuroscience silicon-based neural probes floating probes fixed probes in vivo recording non-human primates visual cortex |
| title | In vivo Recording Quality of Mechanically Decoupled Floating Versus Skull-Fixed Silicon-Based Neural Probes |
| title_full | In vivo Recording Quality of Mechanically Decoupled Floating Versus Skull-Fixed Silicon-Based Neural Probes |
| title_fullStr | In vivo Recording Quality of Mechanically Decoupled Floating Versus Skull-Fixed Silicon-Based Neural Probes |
| title_full_unstemmed | In vivo Recording Quality of Mechanically Decoupled Floating Versus Skull-Fixed Silicon-Based Neural Probes |
| title_short | In vivo Recording Quality of Mechanically Decoupled Floating Versus Skull-Fixed Silicon-Based Neural Probes |
| title_sort | in vivo recording quality of mechanically decoupled floating versus skull fixed silicon based neural probes |
| topic | silicon-based neural probes floating probes fixed probes in vivo recording non-human primates visual cortex |
| url | https://www.frontiersin.org/article/10.3389/fnins.2019.00464/full |
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