Potential Advantages of Bioactive Compounds Extracted From Traditional Chinese Medicine to Inhibit Bone Destructions in Rheumatoid Arthritis
Bone destruction is an important pathological feature of rheumatoid arthritis (RA), which finally leads to the serious decline of life quality in RA patients. Bone metabolism imbalance is the principal factor of bone destruction in RA, which is manifested by excessive osteoclast-mediated bone resorp...
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| Format: | Article |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2020.561962/full |
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| author | Yingjie Shi Yingjie Shi Haiyang Shu Haiyang Shu Xinyu Wang Xinyu Wang Hanxiao Zhao Hanxiao Zhao Cheng Lu Aiping Lu Aiping Lu Xiaojuan He |
| author_facet | Yingjie Shi Yingjie Shi Haiyang Shu Haiyang Shu Xinyu Wang Xinyu Wang Hanxiao Zhao Hanxiao Zhao Cheng Lu Aiping Lu Aiping Lu Xiaojuan He |
| author_sort | Yingjie Shi |
| collection | DOAJ |
| description | Bone destruction is an important pathological feature of rheumatoid arthritis (RA), which finally leads to the serious decline of life quality in RA patients. Bone metabolism imbalance is the principal factor of bone destruction in RA, which is manifested by excessive osteoclast-mediated bone resorption and inadequate osteoblast-mediated bone formation. Although current drugs alleviate the process of bone destruction to a certain extent, there are still many deficiencies. Recent studies have shown that traditional Chinese medicine (TCM) could effectively suppress bone destruction of RA. Some bioactive compounds from TCM have shown good effect on inhibiting osteoclast differentiation and promoting osteoblast proliferation. This article reviews the research progress of bioactive compounds exacted from TCM in inhibiting bone destruction of RA, so as to provide references for further clinical and scientific research. |
| first_indexed | 2024-12-24T00:03:40Z |
| format | Article |
| id | doaj.art-79de3818b2af43bf9804a9e4d5f8335c |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-24T00:03:40Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-79de3818b2af43bf9804a9e4d5f8335c2022-12-21T17:25:04ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122020-10-011110.3389/fphar.2020.561962561962Potential Advantages of Bioactive Compounds Extracted From Traditional Chinese Medicine to Inhibit Bone Destructions in Rheumatoid ArthritisYingjie Shi0Yingjie Shi1Haiyang Shu2Haiyang Shu3Xinyu Wang4Xinyu Wang5Hanxiao Zhao6Hanxiao Zhao7Cheng Lu8Aiping Lu9Aiping Lu10Xiaojuan He11Shanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, ChinaThe Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, ChinaCollege of Medicine, Southwest Jiaotong University, Chengdu, ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, ChinaThe Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, ChinaShanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Chinese Medicine, Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases, Hong Kong Baptist University, Hong Kong, Hong KongInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, ChinaBone destruction is an important pathological feature of rheumatoid arthritis (RA), which finally leads to the serious decline of life quality in RA patients. Bone metabolism imbalance is the principal factor of bone destruction in RA, which is manifested by excessive osteoclast-mediated bone resorption and inadequate osteoblast-mediated bone formation. Although current drugs alleviate the process of bone destruction to a certain extent, there are still many deficiencies. Recent studies have shown that traditional Chinese medicine (TCM) could effectively suppress bone destruction of RA. Some bioactive compounds from TCM have shown good effect on inhibiting osteoclast differentiation and promoting osteoblast proliferation. This article reviews the research progress of bioactive compounds exacted from TCM in inhibiting bone destruction of RA, so as to provide references for further clinical and scientific research.https://www.frontiersin.org/article/10.3389/fphar.2020.561962/fullbone destructionrheumatoid arthritistraditional Chinese medicinebioactive compoundsbone metabolism |
| spellingShingle | Yingjie Shi Yingjie Shi Haiyang Shu Haiyang Shu Xinyu Wang Xinyu Wang Hanxiao Zhao Hanxiao Zhao Cheng Lu Aiping Lu Aiping Lu Xiaojuan He Potential Advantages of Bioactive Compounds Extracted From Traditional Chinese Medicine to Inhibit Bone Destructions in Rheumatoid Arthritis Frontiers in Pharmacology bone destruction rheumatoid arthritis traditional Chinese medicine bioactive compounds bone metabolism |
| title | Potential Advantages of Bioactive Compounds Extracted From Traditional Chinese Medicine to Inhibit Bone Destructions in Rheumatoid Arthritis |
| title_full | Potential Advantages of Bioactive Compounds Extracted From Traditional Chinese Medicine to Inhibit Bone Destructions in Rheumatoid Arthritis |
| title_fullStr | Potential Advantages of Bioactive Compounds Extracted From Traditional Chinese Medicine to Inhibit Bone Destructions in Rheumatoid Arthritis |
| title_full_unstemmed | Potential Advantages of Bioactive Compounds Extracted From Traditional Chinese Medicine to Inhibit Bone Destructions in Rheumatoid Arthritis |
| title_short | Potential Advantages of Bioactive Compounds Extracted From Traditional Chinese Medicine to Inhibit Bone Destructions in Rheumatoid Arthritis |
| title_sort | potential advantages of bioactive compounds extracted from traditional chinese medicine to inhibit bone destructions in rheumatoid arthritis |
| topic | bone destruction rheumatoid arthritis traditional Chinese medicine bioactive compounds bone metabolism |
| url | https://www.frontiersin.org/article/10.3389/fphar.2020.561962/full |
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