The role of TSC2 in breast cancer: a literature review
TSC2 is a tumor suppressor gene as well as a disease-causing gene for autosomal dominant disorder tuberous sclerosis complex (TSC). Research has found that some tumor tissues have lower TSC2 expression levels than normal tissues. Furthermore, low expression of TSC2 is associated with poor prognosis...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1188371/full |
| _version_ | 1797828938730307584 |
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| author | Qiao-Yan Zhu Qiao-Yan Zhu Zhe-Min He Zhe-Min He Wen-Ming Cao Bei Li |
| author_facet | Qiao-Yan Zhu Qiao-Yan Zhu Zhe-Min He Zhe-Min He Wen-Ming Cao Bei Li |
| author_sort | Qiao-Yan Zhu |
| collection | DOAJ |
| description | TSC2 is a tumor suppressor gene as well as a disease-causing gene for autosomal dominant disorder tuberous sclerosis complex (TSC). Research has found that some tumor tissues have lower TSC2 expression levels than normal tissues. Furthermore, low expression of TSC2 is associated with poor prognosis in breast cancer. TSC2 acts as a convergence point of a complex network of signaling pathways and receives signals from the PI3K, AMPK, MAPK, and WNT pathways. It also regulates cellular metabolism and autophagy through inhibition of a mechanistic target of rapamycin complex, which are processes relevant to the progression, treatment, and prognosis of breast cancer. In-depth study of TSC2 functions provides significant guidance for clinical applications in breast cancer, including improving the treatment efficacy, overcoming drug resistance, and predicting prognosis. In this review, protein structure and biological functions of TSC2 were described and recent advances in TSC2 research in different molecular subtypes of breast cancer were summarized. |
| first_indexed | 2024-04-09T13:12:25Z |
| format | Article |
| id | doaj.art-79dea11679ca47b3b3b64af279fc994c |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-09T13:12:25Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-79dea11679ca47b3b3b64af279fc994c2023-05-12T06:05:14ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-05-011310.3389/fonc.2023.11883711188371The role of TSC2 in breast cancer: a literature reviewQiao-Yan Zhu0Qiao-Yan Zhu1Zhe-Min He2Zhe-Min He3Wen-Ming Cao4Bei Li5The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Breast Medical Oncology, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Hangzhou, ChinaThe Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Breast Medical Oncology, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Hangzhou, ChinaDepartment of Breast Medical Oncology, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Hangzhou, ChinaDepartment of Geriatric, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaTSC2 is a tumor suppressor gene as well as a disease-causing gene for autosomal dominant disorder tuberous sclerosis complex (TSC). Research has found that some tumor tissues have lower TSC2 expression levels than normal tissues. Furthermore, low expression of TSC2 is associated with poor prognosis in breast cancer. TSC2 acts as a convergence point of a complex network of signaling pathways and receives signals from the PI3K, AMPK, MAPK, and WNT pathways. It also regulates cellular metabolism and autophagy through inhibition of a mechanistic target of rapamycin complex, which are processes relevant to the progression, treatment, and prognosis of breast cancer. In-depth study of TSC2 functions provides significant guidance for clinical applications in breast cancer, including improving the treatment efficacy, overcoming drug resistance, and predicting prognosis. In this review, protein structure and biological functions of TSC2 were described and recent advances in TSC2 research in different molecular subtypes of breast cancer were summarized.https://www.frontiersin.org/articles/10.3389/fonc.2023.1188371/fullTSC2breast cancersignaling pathwaysmTORPI3K |
| spellingShingle | Qiao-Yan Zhu Qiao-Yan Zhu Zhe-Min He Zhe-Min He Wen-Ming Cao Bei Li The role of TSC2 in breast cancer: a literature review Frontiers in Oncology TSC2 breast cancer signaling pathways mTOR PI3K |
| title | The role of TSC2 in breast cancer: a literature review |
| title_full | The role of TSC2 in breast cancer: a literature review |
| title_fullStr | The role of TSC2 in breast cancer: a literature review |
| title_full_unstemmed | The role of TSC2 in breast cancer: a literature review |
| title_short | The role of TSC2 in breast cancer: a literature review |
| title_sort | role of tsc2 in breast cancer a literature review |
| topic | TSC2 breast cancer signaling pathways mTOR PI3K |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1188371/full |
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