Lower Plasma Total Testosterone Levels Were Associated With Steeper Decline in Brain Glucose Metabolism in Non-demented Older Men
ObjectiveThere is growing evidence that testosterone may be implicated in the pathogenesis of Alzheimer’s disease (AD). We aimed to examine the relationship between plasma total testosterone levels and change in brain glucose metabolism over time among non-demented older people.MethodsThe associatio...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.592845/full |
| _version_ | 1818970712712413184 |
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| author | Xiwu Wang Zhaoting Lv Qian Wu Huitao Liu Yanrou Gu Teng Ye |
| author_facet | Xiwu Wang Zhaoting Lv Qian Wu Huitao Liu Yanrou Gu Teng Ye |
| author_sort | Xiwu Wang |
| collection | DOAJ |
| description | ObjectiveThere is growing evidence that testosterone may be implicated in the pathogenesis of Alzheimer’s disease (AD). We aimed to examine the relationship between plasma total testosterone levels and change in brain glucose metabolism over time among non-demented older people.MethodsThe association of plasma total testosterone levels with change in brain glucose metabolism among non-demented older people was investigated cross-sectionally and longitudinally. Given a significant difference in levels of plasma total testosterone between gender, we performed our analysis in a sex-stratified way. At baseline, 228 non-demented older people were included: 152 males and 76 females.ResultsIn the cross-sectional analysis, no significant relationship between plasma total testosterone levels and brain glucose metabolism was found in males or females. In the longitudinal analysis, we found a significant association of plasma total testosterone levels with change in brain glucose metabolism over time in males, but not in females. More specifically, in males, higher levels of total testosterone in plasma at baseline were associated with slower decline in brain glucose metabolism.ConclusionWe found that higher levels of total testosterone in plasma at baseline were associated with slower decline in brain glucose metabolism in males without dementia, indicating that testosterone may have beneficial effects on brain function. |
| first_indexed | 2024-12-20T14:40:50Z |
| format | Article |
| id | doaj.art-79df9ae2c08845d5b19fcff5ce28d97b |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-20T14:40:50Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-79df9ae2c08845d5b19fcff5ce28d97b2022-12-21T19:37:19ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-04-011310.3389/fnagi.2021.592845592845Lower Plasma Total Testosterone Levels Were Associated With Steeper Decline in Brain Glucose Metabolism in Non-demented Older MenXiwu Wang0Zhaoting Lv1Qian Wu2Huitao Liu3Yanrou Gu4Teng Ye5Department of Psychiatry, Wenzhou Seventh People’s Hospital, Wenzhou, ChinaDepartment of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, ChinaSchool of Mental Health, Wenzhou Medical University, Wenzhou, ChinaDepartment of Orthopedics, Taizhou Hospital of Zhejiang Province, Taizhou, ChinaSchool of Mental Health, Wenzhou Medical University, Wenzhou, ChinaDepartment of Ultrasound, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaObjectiveThere is growing evidence that testosterone may be implicated in the pathogenesis of Alzheimer’s disease (AD). We aimed to examine the relationship between plasma total testosterone levels and change in brain glucose metabolism over time among non-demented older people.MethodsThe association of plasma total testosterone levels with change in brain glucose metabolism among non-demented older people was investigated cross-sectionally and longitudinally. Given a significant difference in levels of plasma total testosterone between gender, we performed our analysis in a sex-stratified way. At baseline, 228 non-demented older people were included: 152 males and 76 females.ResultsIn the cross-sectional analysis, no significant relationship between plasma total testosterone levels and brain glucose metabolism was found in males or females. In the longitudinal analysis, we found a significant association of plasma total testosterone levels with change in brain glucose metabolism over time in males, but not in females. More specifically, in males, higher levels of total testosterone in plasma at baseline were associated with slower decline in brain glucose metabolism.ConclusionWe found that higher levels of total testosterone in plasma at baseline were associated with slower decline in brain glucose metabolism in males without dementia, indicating that testosterone may have beneficial effects on brain function.https://www.frontiersin.org/articles/10.3389/fnagi.2021.592845/fulltestosteroneAlzheimer’s diseasebrain glucose metabolismFDGlongitudinal study |
| spellingShingle | Xiwu Wang Zhaoting Lv Qian Wu Huitao Liu Yanrou Gu Teng Ye Lower Plasma Total Testosterone Levels Were Associated With Steeper Decline in Brain Glucose Metabolism in Non-demented Older Men Frontiers in Aging Neuroscience testosterone Alzheimer’s disease brain glucose metabolism FDG longitudinal study |
| title | Lower Plasma Total Testosterone Levels Were Associated With Steeper Decline in Brain Glucose Metabolism in Non-demented Older Men |
| title_full | Lower Plasma Total Testosterone Levels Were Associated With Steeper Decline in Brain Glucose Metabolism in Non-demented Older Men |
| title_fullStr | Lower Plasma Total Testosterone Levels Were Associated With Steeper Decline in Brain Glucose Metabolism in Non-demented Older Men |
| title_full_unstemmed | Lower Plasma Total Testosterone Levels Were Associated With Steeper Decline in Brain Glucose Metabolism in Non-demented Older Men |
| title_short | Lower Plasma Total Testosterone Levels Were Associated With Steeper Decline in Brain Glucose Metabolism in Non-demented Older Men |
| title_sort | lower plasma total testosterone levels were associated with steeper decline in brain glucose metabolism in non demented older men |
| topic | testosterone Alzheimer’s disease brain glucose metabolism FDG longitudinal study |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.592845/full |
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