Functional Reciprocity of Amyloids and Antimicrobial Peptides: Rethinking the Role of Supramolecular Assembly in Host Defense, Immune Activation, and Inflammation

Functional Reciprocity of Amyloids and Antimicrobial Peptides: Rethinking the Role of Supramolecular Assembly in Host Defense, Immune Activation, and Inflammation

Pathological self-assembly is a concept that is classically associated with amyloids, such as amyloid-β (Aβ) in Alzheimer's disease and α-synuclein in Parkinson's disease. In prokaryotic organisms, amyloids are assembled extracellularly in a similar fashion to human amyloids. Pathogenicity...

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Bibliographic Details
Main Authors: Ernest Y. Lee, Yashes Srinivasan, Jaime de Anda, Lauren K. Nicastro, Çagla Tükel, Gerard C. L. Wong
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
antimicrobial peptides
amyloids
self-assembly
Toll-like receptors
innate immunity
autoimmune diseases
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01629/full

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