The Association of Coagulation Indicators and Coagulant Agents With 30-Day Mortality of Critical Diabetics
Diabetes, regarded as a global health concerned disease, was focused by the World Health Organization (WHO). Patients with diabetes may have a hypercoagulable and hypo-fibrinolysis state. There is lots of research about cardiovascular effects on diabetes patients, but less about the coagulation syst...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-07-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296211026385 |
| _version_ | 1818921757565779968 |
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| author | Yingxin Huang MM Zhihua Zhong MSc Fanna Liu PhD |
| author_facet | Yingxin Huang MM Zhihua Zhong MSc Fanna Liu PhD |
| author_sort | Yingxin Huang MM |
| collection | DOAJ |
| description | Diabetes, regarded as a global health concerned disease, was focused by the World Health Organization (WHO). Patients with diabetes may have a hypercoagulable and hypo-fibrinolysis state. There is lots of research about cardiovascular effects on diabetes patients, but less about the coagulation system. This study is designed to investigate the relationship between coagulation indicators and 30-day mortality of critical diabetes patients. In this retrospective, single-center study, we included adult patients diagnosed with diabetes. Data, including demographic, complication, laboratory tests, scoring system, and anticoagulant treatment, were extracted from Medical Information Mart for Intensive Care (MIMIC-III). The receiver operating characteristic (ROC) curve and Kaplan-Meier curve were applied to predict the association of mortality and coagulation indicators. Cox hazard regression model and subgroup analysis were used to analyze the risk factors associated with 30-day mortality. A total of 4026 patients with diabetes mellitus were included in our study, of whom 3312 survived after admitted to the hospital and 714 died. Cox hazard regression showed anticoagulant therapy might decrease the risk of 30-day mortality after adjusted. In age <70 subgroup analysis, we found that patients with PTT <26.8 s or lightly increased PT may increase odds of 30-day hospital death (HR, 95%CI, 2.044 (1.376, 3.034), 1.562 (1.042, 2.343)). When age >70, lightly increased PTT may reduce the risk of mortality, but PT >16.3 s, a high level of hypo-coagulation state, increase risk of mortality (HR, 95%CI, 0.756 (0.574, 0.996), 1.756 (1.129, 2.729)). Critical diabetes patients may benefit from anticoagulant agents. The abnormal coagulant function is related to the risk of 30-day mortality. |
| first_indexed | 2024-12-20T01:42:43Z |
| format | Article |
| id | doaj.art-79e18d8998db403eacadf6bd01838119 |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-12-20T01:42:43Z |
| publishDate | 2021-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-79e18d8998db403eacadf6bd018381192022-12-21T19:57:51ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232021-07-012710.1177/10760296211026385The Association of Coagulation Indicators and Coagulant Agents With 30-Day Mortality of Critical DiabeticsYingxin Huang MM0Zhihua Zhong MSc1Fanna Liu PhD2 Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China College of Information Science and Technology, Jinan University, Guangzhou, Guangdong, China Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, ChinaDiabetes, regarded as a global health concerned disease, was focused by the World Health Organization (WHO). Patients with diabetes may have a hypercoagulable and hypo-fibrinolysis state. There is lots of research about cardiovascular effects on diabetes patients, but less about the coagulation system. This study is designed to investigate the relationship between coagulation indicators and 30-day mortality of critical diabetes patients. In this retrospective, single-center study, we included adult patients diagnosed with diabetes. Data, including demographic, complication, laboratory tests, scoring system, and anticoagulant treatment, were extracted from Medical Information Mart for Intensive Care (MIMIC-III). The receiver operating characteristic (ROC) curve and Kaplan-Meier curve were applied to predict the association of mortality and coagulation indicators. Cox hazard regression model and subgroup analysis were used to analyze the risk factors associated with 30-day mortality. A total of 4026 patients with diabetes mellitus were included in our study, of whom 3312 survived after admitted to the hospital and 714 died. Cox hazard regression showed anticoagulant therapy might decrease the risk of 30-day mortality after adjusted. In age <70 subgroup analysis, we found that patients with PTT <26.8 s or lightly increased PT may increase odds of 30-day hospital death (HR, 95%CI, 2.044 (1.376, 3.034), 1.562 (1.042, 2.343)). When age >70, lightly increased PTT may reduce the risk of mortality, but PT >16.3 s, a high level of hypo-coagulation state, increase risk of mortality (HR, 95%CI, 0.756 (0.574, 0.996), 1.756 (1.129, 2.729)). Critical diabetes patients may benefit from anticoagulant agents. The abnormal coagulant function is related to the risk of 30-day mortality.https://doi.org/10.1177/10760296211026385 |
| spellingShingle | Yingxin Huang MM Zhihua Zhong MSc Fanna Liu PhD The Association of Coagulation Indicators and Coagulant Agents With 30-Day Mortality of Critical Diabetics Clinical and Applied Thrombosis/Hemostasis |
| title | The Association of Coagulation Indicators and Coagulant Agents With 30-Day Mortality of Critical Diabetics |
| title_full | The Association of Coagulation Indicators and Coagulant Agents With 30-Day Mortality of Critical Diabetics |
| title_fullStr | The Association of Coagulation Indicators and Coagulant Agents With 30-Day Mortality of Critical Diabetics |
| title_full_unstemmed | The Association of Coagulation Indicators and Coagulant Agents With 30-Day Mortality of Critical Diabetics |
| title_short | The Association of Coagulation Indicators and Coagulant Agents With 30-Day Mortality of Critical Diabetics |
| title_sort | association of coagulation indicators and coagulant agents with 30 day mortality of critical diabetics |
| url | https://doi.org/10.1177/10760296211026385 |
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