Effects of monensin supplementation on rumen fermentation, methane emissions, nitrogen balance, and metabolic responses of dairy cows: A systematic review and dose-response meta-analysis
ABSTRACT: To investigate the effects of supplemental monensin administration on the metabolic responses of dairy cows, a systematic review and dose-response meta-analysis were conducted. Initially, 604 studies were identified through comprehensive database searches, including Google Scholar, Scopus,...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Journal of Dairy Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022030223006501 |
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| author | M.R. Rezaei Ahvanooei M.A. Norouzian A.H. Piray P. Vahmani M.H. Ghaffari |
| author_facet | M.R. Rezaei Ahvanooei M.A. Norouzian A.H. Piray P. Vahmani M.H. Ghaffari |
| author_sort | M.R. Rezaei Ahvanooei |
| collection | DOAJ |
| description | ABSTRACT: To investigate the effects of supplemental monensin administration on the metabolic responses of dairy cows, a systematic review and dose-response meta-analysis were conducted. Initially, 604 studies were identified through comprehensive database searches, including Google Scholar, Scopus, Science Direct, and PubMed, using key words related to dairy cows, monensin, and metabolic outcomes. After a 2-stage screening process, 51 articles with a total of 60 experiments were selected for meta-analysis based on criteria such as study implementation date between 2001 and 2022, presence of a control group that did not receive monensin supplementation, reporting of at least 1 outcome variable, and presentation of means and corresponding errors. The meta-analysis used the 1-stage random-effects method, and sensitivity analyses were performed to assess the robustness of the results. The results showed that the administration of monensin at a dosage of 19 to 26 mg/kg was inversely related to methane emissions and that the administration of monensin at a dosage of 18 to 50 mg/kg resulted in a significant decrease in dry matter intake. Administration of monensin at doses of 13 to 28 and 15 to 24 mg/kg also resulted in a significant decrease in ruminal acetate proportion and an increase in propionate proportion, respectively, with no effects on ruminal butyrate, NH3, or pH levels. We found no effects on blood parameters or nitrogen retention, but a significant negative correlation was observed between monensin supplementation and fecal nitrogen excretion. Based on the analysis of all variables evaluated, the optimal dose range of monensin was estimated to be 19 to 24 mg/kg. |
| first_indexed | 2024-03-08T14:22:17Z |
| format | Article |
| id | doaj.art-79e1e38271884e4a869a94c56436f335 |
| institution | Directory Open Access Journal |
| issn | 0022-0302 |
| language | English |
| last_indexed | 2024-03-08T14:22:17Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Dairy Science |
| spelling | doaj.art-79e1e38271884e4a869a94c56436f3352024-01-14T05:34:51ZengElsevierJournal of Dairy Science0022-03022024-01-011071594611Effects of monensin supplementation on rumen fermentation, methane emissions, nitrogen balance, and metabolic responses of dairy cows: A systematic review and dose-response meta-analysisM.R. Rezaei Ahvanooei0M.A. Norouzian1A.H. Piray2P. Vahmani3M.H. Ghaffari4Department of Animals and Poultry Science, College of Aburaihan, University of Tehran, 3391653755 Tehran, Iran; Corresponding authorsDepartment of Animals and Poultry Science, College of Aburaihan, University of Tehran, 3391653755 Tehran, IranDepartment of Animal Science, College of Agriculture and Natural Resources, Razi University, 6714414971 Kermanshah, IranDepartment of Animal Science, University of California, Davis, Davis, CA 95616Institute of Animal Science, University of Bonn, 53115 Bonn, Germany; Corresponding authorsABSTRACT: To investigate the effects of supplemental monensin administration on the metabolic responses of dairy cows, a systematic review and dose-response meta-analysis were conducted. Initially, 604 studies were identified through comprehensive database searches, including Google Scholar, Scopus, Science Direct, and PubMed, using key words related to dairy cows, monensin, and metabolic outcomes. After a 2-stage screening process, 51 articles with a total of 60 experiments were selected for meta-analysis based on criteria such as study implementation date between 2001 and 2022, presence of a control group that did not receive monensin supplementation, reporting of at least 1 outcome variable, and presentation of means and corresponding errors. The meta-analysis used the 1-stage random-effects method, and sensitivity analyses were performed to assess the robustness of the results. The results showed that the administration of monensin at a dosage of 19 to 26 mg/kg was inversely related to methane emissions and that the administration of monensin at a dosage of 18 to 50 mg/kg resulted in a significant decrease in dry matter intake. Administration of monensin at doses of 13 to 28 and 15 to 24 mg/kg also resulted in a significant decrease in ruminal acetate proportion and an increase in propionate proportion, respectively, with no effects on ruminal butyrate, NH3, or pH levels. We found no effects on blood parameters or nitrogen retention, but a significant negative correlation was observed between monensin supplementation and fecal nitrogen excretion. Based on the analysis of all variables evaluated, the optimal dose range of monensin was estimated to be 19 to 24 mg/kg.http://www.sciencedirect.com/science/article/pii/S0022030223006501meta-analysisfermentationmetabolic parametersmonensin |
| spellingShingle | M.R. Rezaei Ahvanooei M.A. Norouzian A.H. Piray P. Vahmani M.H. Ghaffari Effects of monensin supplementation on rumen fermentation, methane emissions, nitrogen balance, and metabolic responses of dairy cows: A systematic review and dose-response meta-analysis Journal of Dairy Science meta-analysis fermentation metabolic parameters monensin |
| title | Effects of monensin supplementation on rumen fermentation, methane emissions, nitrogen balance, and metabolic responses of dairy cows: A systematic review and dose-response meta-analysis |
| title_full | Effects of monensin supplementation on rumen fermentation, methane emissions, nitrogen balance, and metabolic responses of dairy cows: A systematic review and dose-response meta-analysis |
| title_fullStr | Effects of monensin supplementation on rumen fermentation, methane emissions, nitrogen balance, and metabolic responses of dairy cows: A systematic review and dose-response meta-analysis |
| title_full_unstemmed | Effects of monensin supplementation on rumen fermentation, methane emissions, nitrogen balance, and metabolic responses of dairy cows: A systematic review and dose-response meta-analysis |
| title_short | Effects of monensin supplementation on rumen fermentation, methane emissions, nitrogen balance, and metabolic responses of dairy cows: A systematic review and dose-response meta-analysis |
| title_sort | effects of monensin supplementation on rumen fermentation methane emissions nitrogen balance and metabolic responses of dairy cows a systematic review and dose response meta analysis |
| topic | meta-analysis fermentation metabolic parameters monensin |
| url | http://www.sciencedirect.com/science/article/pii/S0022030223006501 |
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