Preclinical Evidence of Paeoniflorin Effectiveness for the Management of Cerebral Ischemia/Reperfusion Injury: A Systematic Review and Meta-Analysis
Background: Vessel recanalization is the main treatment for ischemic stroke; however, not all patients benefit from it. This lack of treatment benefit is related to the accompanying ischemia-reperfusion (I/R) injury. Therefore, neuroprotective therapy for I/R Injury needs to be further studied. Paeo...
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| Format: | Article |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.827770/full |
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| author | Anzhu Wang Anzhu Wang Wei Zhao Kaituo Yan Pingping Huang Pingping Huang Hongwei Zhang Hongwei Zhang Xiaochang Ma Xiaochang Ma |
| author_facet | Anzhu Wang Anzhu Wang Wei Zhao Kaituo Yan Pingping Huang Pingping Huang Hongwei Zhang Hongwei Zhang Xiaochang Ma Xiaochang Ma |
| author_sort | Anzhu Wang |
| collection | DOAJ |
| description | Background: Vessel recanalization is the main treatment for ischemic stroke; however, not all patients benefit from it. This lack of treatment benefit is related to the accompanying ischemia-reperfusion (I/R) injury. Therefore, neuroprotective therapy for I/R Injury needs to be further studied. Paeonia lactiflora Pall. is a commonly used for ischemic stroke management in traditional Chinese medicine; its main active ingredient is paeoniflorin (PF). We aimed to determine the PF’s effects and the underlying mechanisms in instances of cerebral I/R injury.Methods: We searched seven databases from their inception to July 2021.SYRCLE’s risk of bias tool was used to assess methodological quality. Review Manager 5.3 and STATA 12.0 software were used for meta-analysis.Results: Thirteen studies, including 282 animals overall, were selected. The meta-analyses showed compared to control treatment, PF significantly reduced neurological severity scores, cerebral infarction size, and brain water content (p = 0.000). In the PF treatment groups, the apoptosis cells and levels of inflammatory factors (IL-1β) decreased compared to those in the control groups (p = 0.000).Conclusion: Our results suggest that PF is a promising therapeutic for cerebral I/R injury management. However, to evaluate the effects and safety of PF in a more accurate manner, additional preclinical studies are necessary. |
| first_indexed | 2024-12-13T22:37:43Z |
| format | Article |
| id | doaj.art-79e25c5959994a9095eb816d60938006 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-13T22:37:43Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-79e25c5959994a9095eb816d609380062022-12-21T23:28:56ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-04-011310.3389/fphar.2022.827770827770Preclinical Evidence of Paeoniflorin Effectiveness for the Management of Cerebral Ischemia/Reperfusion Injury: A Systematic Review and Meta-AnalysisAnzhu Wang0Anzhu Wang1Wei Zhao2Kaituo Yan3Pingping Huang4Pingping Huang5Hongwei Zhang6Hongwei Zhang7Xiaochang Ma8Xiaochang Ma9Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGraduate School, China Academy of Chinese Medical Sciences, Beijing, ChinaYidu Central Hospital of Weifang, Weifang, ChinaYidu Central Hospital of Weifang, Weifang, ChinaXiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGraduate School, China Academy of Chinese Medical Sciences, Beijing, ChinaXiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGraduate School, China Academy of Chinese Medical Sciences, Beijing, ChinaXiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaNational Clinical Research Center for Chinese Medicine Cardiology, Beijing, ChinaBackground: Vessel recanalization is the main treatment for ischemic stroke; however, not all patients benefit from it. This lack of treatment benefit is related to the accompanying ischemia-reperfusion (I/R) injury. Therefore, neuroprotective therapy for I/R Injury needs to be further studied. Paeonia lactiflora Pall. is a commonly used for ischemic stroke management in traditional Chinese medicine; its main active ingredient is paeoniflorin (PF). We aimed to determine the PF’s effects and the underlying mechanisms in instances of cerebral I/R injury.Methods: We searched seven databases from their inception to July 2021.SYRCLE’s risk of bias tool was used to assess methodological quality. Review Manager 5.3 and STATA 12.0 software were used for meta-analysis.Results: Thirteen studies, including 282 animals overall, were selected. The meta-analyses showed compared to control treatment, PF significantly reduced neurological severity scores, cerebral infarction size, and brain water content (p = 0.000). In the PF treatment groups, the apoptosis cells and levels of inflammatory factors (IL-1β) decreased compared to those in the control groups (p = 0.000).Conclusion: Our results suggest that PF is a promising therapeutic for cerebral I/R injury management. However, to evaluate the effects and safety of PF in a more accurate manner, additional preclinical studies are necessary.https://www.frontiersin.org/articles/10.3389/fphar.2022.827770/fullpreclinical evidencepotential mechanismspaeoniflorincerebral ischemia-reperfusion injuryanimal studies |
| spellingShingle | Anzhu Wang Anzhu Wang Wei Zhao Kaituo Yan Pingping Huang Pingping Huang Hongwei Zhang Hongwei Zhang Xiaochang Ma Xiaochang Ma Preclinical Evidence of Paeoniflorin Effectiveness for the Management of Cerebral Ischemia/Reperfusion Injury: A Systematic Review and Meta-Analysis Frontiers in Pharmacology preclinical evidence potential mechanisms paeoniflorin cerebral ischemia-reperfusion injury animal studies |
| title | Preclinical Evidence of Paeoniflorin Effectiveness for the Management of Cerebral Ischemia/Reperfusion Injury: A Systematic Review and Meta-Analysis |
| title_full | Preclinical Evidence of Paeoniflorin Effectiveness for the Management of Cerebral Ischemia/Reperfusion Injury: A Systematic Review and Meta-Analysis |
| title_fullStr | Preclinical Evidence of Paeoniflorin Effectiveness for the Management of Cerebral Ischemia/Reperfusion Injury: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Preclinical Evidence of Paeoniflorin Effectiveness for the Management of Cerebral Ischemia/Reperfusion Injury: A Systematic Review and Meta-Analysis |
| title_short | Preclinical Evidence of Paeoniflorin Effectiveness for the Management of Cerebral Ischemia/Reperfusion Injury: A Systematic Review and Meta-Analysis |
| title_sort | preclinical evidence of paeoniflorin effectiveness for the management of cerebral ischemia reperfusion injury a systematic review and meta analysis |
| topic | preclinical evidence potential mechanisms paeoniflorin cerebral ischemia-reperfusion injury animal studies |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.827770/full |
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