Controversial Role of Kisspeptins/KiSS-1R Signaling System in Tumor Development
KiSS-1 was first described as a metastasis suppressor gene in malignant melanoma. KiSS-1 encodes a 145 amino-acid residue peptide that is further processed, producing the 54 amino acid metastin and shorter peptides collectively named kisspeptins (KPs). KPs bind and activate KiSS-1R (GPR54). Although...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-04-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fendo.2018.00192/full |
| _version_ | 1818132099711893504 |
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| author | Federica Fratangelo Maria Vincenza Carriero Maria Letizia Motti Maria Letizia Motti |
| author_facet | Federica Fratangelo Maria Vincenza Carriero Maria Letizia Motti Maria Letizia Motti |
| author_sort | Federica Fratangelo |
| collection | DOAJ |
| description | KiSS-1 was first described as a metastasis suppressor gene in malignant melanoma. KiSS-1 encodes a 145 amino-acid residue peptide that is further processed, producing the 54 amino acid metastin and shorter peptides collectively named kisspeptins (KPs). KPs bind and activate KiSS-1R (GPR54). Although the KPs system has been extensively studied for its role in endocrinology of reproductive axis in mammals, its role in cancer is still controversial. Experimental evidences show that KP system exerts an anti-metastatic effect by the regulation of cellular migration and invasion in several cancer types. However, the role of KPs/KiSS-1R is very complex. Genomic studies suggest that KiSS-1/KiSS-1R expression might be different in the various stages of tumor development. Furthermore, overexpression of KiSS-1R has been reported to elicit drug resistance in triple negative breast cancer. In this review, we focused on multiple functions exerted by the KPs/KiSS-1R system in regulating tumor progression. |
| first_indexed | 2024-12-11T08:31:27Z |
| format | Article |
| id | doaj.art-79e2d93bb79a41d28676b89d4462e2a3 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-11T08:31:27Z |
| publishDate | 2018-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-79e2d93bb79a41d28676b89d4462e2a32022-12-22T01:14:27ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922018-04-01910.3389/fendo.2018.00192351382Controversial Role of Kisspeptins/KiSS-1R Signaling System in Tumor DevelopmentFederica Fratangelo0Maria Vincenza Carriero1Maria Letizia Motti2Maria Letizia Motti3IRCCS Istituto Nazionale Tumori “Fondazione G. Pascale”, Naples, ItalyIRCCS Istituto Nazionale Tumori “Fondazione G. Pascale”, Naples, ItalyIRCCS Istituto Nazionale Tumori “Fondazione G. Pascale”, Naples, ItalyParthenope University of Naples, Naples, ItalyKiSS-1 was first described as a metastasis suppressor gene in malignant melanoma. KiSS-1 encodes a 145 amino-acid residue peptide that is further processed, producing the 54 amino acid metastin and shorter peptides collectively named kisspeptins (KPs). KPs bind and activate KiSS-1R (GPR54). Although the KPs system has been extensively studied for its role in endocrinology of reproductive axis in mammals, its role in cancer is still controversial. Experimental evidences show that KP system exerts an anti-metastatic effect by the regulation of cellular migration and invasion in several cancer types. However, the role of KPs/KiSS-1R is very complex. Genomic studies suggest that KiSS-1/KiSS-1R expression might be different in the various stages of tumor development. Furthermore, overexpression of KiSS-1R has been reported to elicit drug resistance in triple negative breast cancer. In this review, we focused on multiple functions exerted by the KPs/KiSS-1R system in regulating tumor progression.http://journal.frontiersin.org/article/10.3389/fendo.2018.00192/fullkisspeptinKiSS-1Rtumor developmenttumor invasionmetastasis |
| spellingShingle | Federica Fratangelo Maria Vincenza Carriero Maria Letizia Motti Maria Letizia Motti Controversial Role of Kisspeptins/KiSS-1R Signaling System in Tumor Development Frontiers in Endocrinology kisspeptin KiSS-1R tumor development tumor invasion metastasis |
| title | Controversial Role of Kisspeptins/KiSS-1R Signaling System in Tumor Development |
| title_full | Controversial Role of Kisspeptins/KiSS-1R Signaling System in Tumor Development |
| title_fullStr | Controversial Role of Kisspeptins/KiSS-1R Signaling System in Tumor Development |
| title_full_unstemmed | Controversial Role of Kisspeptins/KiSS-1R Signaling System in Tumor Development |
| title_short | Controversial Role of Kisspeptins/KiSS-1R Signaling System in Tumor Development |
| title_sort | controversial role of kisspeptins kiss 1r signaling system in tumor development |
| topic | kisspeptin KiSS-1R tumor development tumor invasion metastasis |
| url | http://journal.frontiersin.org/article/10.3389/fendo.2018.00192/full |
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